ChemicalBook >> CAS DataBase List >>1H-3-Benzazepin-7-ol,8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-,hydrobroMide(1:1)

1H-3-Benzazepin-7-ol,8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-,hydrobroMide(1:1)

1H-3-Benzazepin-7-ol,8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-,hydrobroMide(1:1) structure

CAS No.: 108179-91-5

Chemical Name:: 1H-3-Benzazepin-7-ol,8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-,hydrobroMide(1:1)

Synonyms: 113762;CS-2574;SKF83566HG;SKF 83566 hydrobromide, D1 receptor antagonist;SKF 83566 hydrobromide, D1 receptor antagonist (DMSO solution);8-bromo-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol:hydrobromide;8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol hydrobromide;1H-3-Benzazepin-7-ol,8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-,hydrobroMide(1;1H-3-Benzazepin-7-ol,8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-,hydrobroMide(1:1)

CBNumber:: CB82712884

Molecular Formula:: C17H19Br2NO

Molecular Weight:: 413.15

MDL Number:

MOL File:: 108179-91-5.mol

Last updated:2025-04-17 18:22:24

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1H-3-Benzazepin-7-ol,8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-,hydrobroMide(1:1) Properties

storage temp.	Desiccate at RT
solubility	Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
form	Powder

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H302-H335-H315

Precautionary statements

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501

NFPA 704

	0
2		0

1H-3-Benzazepin-7-ol,8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-,hydrobroMide(1:1) price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	29480	SKF 83566 (hydrobromide)	108179-91-5	5mg	$62	2024-03-01	Buy
Cayman Chemical	29480	SKF 83566 (hydrobromide)	108179-91-5	10mg	$96	2024-03-01	Buy
Cayman Chemical	29480	SKF 83566 (hydrobromide)	108179-91-5	25mg	$194	2024-03-01	Buy
TRC	S550060	SKF83566Hydrobromide	108179-91-5	2.5mg	$185	2021-12-16	Buy
AK Scientific	Z3071	8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-olhydrobromide	108179-91-5	250mg	$514	2021-12-16	Buy

Product number	Packaging	Price	Buy
29480	5mg	$62	Buy
29480	10mg	$96	Buy
29480	25mg	$194	Buy
S550060	2.5mg	$185	Buy
Z3071	250mg	$514	Buy

1H-3-Benzazepin-7-ol,8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-,hydrobroMide(1:1) Chemical Properties,Uses,Production

Uses

SKF 83566 Hydrobromide is a very potent and selective D1-like dopamine receptor antagonist, specifically at the 5-HT2 receptor.

in vivo

SKF 83566 hydrobromide (oral administration; 20 μg/mL; 7 days) alone has no effects on altering LTP (115%). However, combinnation of SKF 83566 and nicotine significantly blocks the enhancement of long-term synaptic potentiation (LTP) induced by pretreatment with nicotine (SKF 83566+nicotine+cocaine, 120%; nicotine+cocaine, 143%)^[1].

Animal Model:	Male C57BL6/J mice (6- to 9-wk-old)^[1]
Dosage:	20 μg/mL (Together with nicotine for 7 d, followed by the injection of cocaine)
Administration:	Oral administration; 7 days
Result:	Blocked nicotine and cocaine-induced facilitation of LTP.

IC 50

D₁ Receptor; D₅ Receptor; 5-HT₂ Receptor: 11 nM (Ki)

storage

room temperature (desiccate)

1H-3-Benzazepin-7-ol,8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-,hydrobroMide(1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

1H-3-Benzazepin-7-ol,8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-,hydrobroMide(1:1) Suppliers

Global( 26)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32202	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66099280 17798518460	cfzhang@aikonchem.com	China	19915	55
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	25003	65
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4601	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9803	58
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	71829	60
Shanghai Pingguo Pharmaceutical Co., Ltd.	021-20432229	2412110556@qq.com	China	6017	55
Cckinase, Inc.	+1 (732)236-3202	sales@cckinase.com	United States	2738	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	55
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
Shanghai Pingguo Pharmaceutical Co., Ltd.	55
Cckinase, Inc.	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58

View Lastest Price from 1H-3-Benzazepin-7-ol,8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-,hydrobroMide(1:1) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-24	SKF-83566 hydrobromide 108179-91-5	US $240.00-485.00 / mg			10g	TargetMol Chemicals Inc.

SKF-83566 hydrobromide
108179-91-5
US $240.00-485.00 / mg
TargetMol Chemicals Inc.

1H-3-Benzazepin-7-ol,8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-,hydrobroMide(1:1) SKF83566HG 8-bromo-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol:hydrobromide 1H-3-Benzazepin-7-ol,8-broMo-2,3,4,5-tetrahydro-3-Methyl-5-phenyl-,hydrobroMide(1 113762 8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol hydrobromide CS-2574 SKF 83566 hydrobromide, D1 receptor antagonist (DMSO solution) SKF 83566 hydrobromide, D1 receptor antagonist 108179-91-5