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ChemicalBook >> CAS DataBase List >>Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]-

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]-

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]- Structure
Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]- structure
CAS No.
1431411-60-7
Chemical Name:
Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]-
Synonyms
SIRT-IN-1;SIRT-IN-1, 10 mM in DMSO;Inhibitor,Sirtuin,SIRT IN 1,SIRTIN1,inhibit;4-[4-[2-(2,2-dimethylpropanoylamino)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxamide;4-[4-[2-[(2,2-dimethyl-1-oxopropyl)amino]ethyl]-1-piperidinyl]-Thieno[3,2-d]pyrimidine-6-carboxamide;Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]-
CBNumber:
CB82716387
Molecular Formula:
C19H27N5O2S
Molecular Weight:
389.51498
MDL Number:
MFCD28386339
MOL File:
1431411-60-7.mol
Last updated:2025-01-27 09:38:02
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Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]- Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
color Off-white to light yellow
UNSPSC Code 12352200
NACRES NA.77

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth Carbosynth BT166491 Sirt-IN-1 NEW 1431411-60-7 10mg $185 2021-12-16 Buy
AK Scientific 5363DU 4-(4-{2-[(2,2-Dimethylpropanoyl)amino]ethyl}piperidin-1-Yl)thieno[3,2-D]pyrimidine-6-Carboxamide 1431411-60-7 10mg $299 2021-12-16 Buy
Biosynth Carbosynth BT166491 Sirt-IN-1 NEW 1431411-60-7 50mg $647.5 2021-12-16 Buy
Product number Packaging Price Buy
BT166491 10mg $185 Buy
5363DU 10mg $299 Buy
BT166491 50mg $647.5 Buy

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]- Chemical Properties,Uses,Production

Description

SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.

SIRT-IN-1 (compound 28) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 0.015, 0.010, 0.033 μM, respectively. SIRT-IN-1 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1].

References

[1]. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]- Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32965 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
SPIRO PHARMA eric_feng1954@126.com China 9248 55
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 7314 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 lucy@atkchemical.com China 9987 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4342 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10524 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24644 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
SPIRO PHARMA 55
Shanghai Chaolan Chemical Technology Center 58
Shanghai SuperLan Chemcial Technique Centre 58
Fan De(Beijing) Biotechnology Co., Ltd. 58
ShangHai ChuanQian Chemcial Technique Centre 58
cjbscvictory 58
TargetMol Chemicals Inc. 58

View Lastest Price from Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SIRT-IN-1 pictures 2024-11-19 SIRT-IN-1
1431411-60-7
 US $84.00-328.00 / mg 97.07% 10g TargetMol Chemicals Inc.
SIRT-IN-1 pictures 2024-11-19 SIRT-IN-1
1431411-60-7
 US $84.00-328.00 / mg 97.07% 10g TargetMol Chemicals Inc.
  • SIRT-IN-1 pictures
  • SIRT-IN-1
    1431411-60-7
  • US $84.00-328.00 / mg
  • 97.07%
  • TargetMol Chemicals Inc.
  • SIRT-IN-1 pictures
  • SIRT-IN-1
    1431411-60-7
  • US $84.00-328.00 / mg
  • 97.07%
  • TargetMol Chemicals Inc.

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]- Spectrum

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]-(1431411-60-7)1HNMR
4-[4-[2-[(2,2-dimethyl-1-oxopropyl)amino]ethyl]-1-piperidinyl]-Thieno[3,2-d]pyrimidine-6-carboxamide Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]- 4-[4-[2-(2,2-dimethylpropanoylamino)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxamide SIRT-IN-1 Inhibitor,Sirtuin,SIRT IN 1,SIRTIN1,inhibit SIRT-IN-1, 10 mM in DMSO 1431411-60-7