ChemicalBook >> CAS DataBase List >>Syntelin
Syntelin
- CAS No.
- 438481-33-5
- Chemical Name:
- Syntelin
- Synonyms
- Syntelin;2-((5-(((4-amino-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetic acid;Acetic acid, 2-[[5-[[(4-amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)thio]methyl]-4-phenyl-4H-1,2,4-triazol-3-yl]thio]-;2-[[5-[(4-amino-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl)sulfanylmethyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]acetic acid
- CBNumber:
- CB82731146
- Molecular Formula:
- C21H20N6O2S3
- Molecular Weight:
- 484.62
- MDL Number:
- MFCD03147450
- MOL File:
- 438481-33-5.mol
Last updated:2023-03-31 09:12:58
Syntelin Chemical Properties,Uses,Production
Description
Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 value of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highly selective for CENP-E. Syntelin binds to different sites from those of GSK923295, a recently identified CENP-E ATPase inhibitor, as syntelin inhibits CENP-E mutants resistant to GSK923295 in a manner indistinguishable from that of wild type motor. Syntelin represents a novel class of CENP-E motor inhibitor.
Syntelin Preparation Products And Raw materials
Raw materials
Preparation Products
Syntelin Suppliers
Global( 5)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28091 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
Syntelin
2-((5-(((4-amino-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetic acid
2-[[5-[(4-amino-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl)sulfanylmethyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]acetic acid
Acetic acid, 2-[[5-[[(4-amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)thio]methyl]-4-phenyl-4H-1,2,4-triazol-3-yl]thio]-
438481-33-5