6-(octylaMino)pyriMidine-2,4(1H,3H)-dione
- CAS No.
- 83797-69-7
- Chemical Name:
- 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione
- Synonyms
- 6-OAU;CS-2658;GTPL5846;6-OAU, >98%;GTPL5846, >98%;6-OAU(GTPL5846);GTPL-5846 (6-OAU);6-OAU, 10 mM in DMSO;GTPL 5846;GTPL5846;6-OAU;GTPL-5846;6-(Octylamino)-2,4(1H,3H)-pyrimidinedione
- CBNumber:
- CB82736888
- Molecular Formula:
- C12H21N3O2
- Molecular Weight:
- 239.31
- MDL Number:
- MFCD28900678
- MOL File:
- 83797-69-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
6-(octylaMino)pyriMidine-2,4(1H,3H)-dione price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17687 | 6-OAU ≥98% | 83797-69-7 | 1mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 17687 | 6-OAU ≥98% | 83797-69-7 | 5mg | $388 | 2024-03-01 | Buy |
| Cayman Chemical | 17687 | 6-OAU ≥98% | 83797-69-7 | 10mg | $638 | 2024-03-01 | Buy |
| ApexBio Technology | C5367 | 6-OAU | 83797-69-7 | 10mg | $677 | 2021-12-16 | Buy |
| ApexBio Technology | C5367 | 6-OAU | 83797-69-7 | 1mg | $90 | 2021-12-16 | Buy |
6-(octylaMino)pyriMidine-2,4(1H,3H)-dione Chemical Properties,Uses,Production
Description
GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations. GPR84 is expressed in leukocytes and its expression is further induced by LPS. 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM). It has insignificant actions at a panel of 69 other receptors, channels, or transporters. 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages. In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.
Uses
6-OAU (GTPL5846) (6-n-octylaminouracil) is an GPR84 (G protein-coupled receptor 84) agonist, with an EC50 value of 105 nM. 6-OAU works as a chemoattractant to both PMNs and macrophages, and amplifies the proinflammatory cytokine IL-8, shows proinflammatory function. 6-OAU also displays anti-bacterial function[1][2].
in vitro
a previous study identified 6-oau as a surrogate agonist for gpr84. it was found that 6-oau and potential ligands were able to stimulate [(35)s]gtp binding and accumulate phosphoinositides in a gpr84-dependent manner. moreover, 6-oau could internalize gpr84-egfp from the cell surface. in addition, results showed that both 6-oau and the potential ligands could elicite chemotaxis of human polymorphonuclear leukocytes (pmns) and macrophages and amplify lps-stimulated production of the proinflammatory cytokine il-8 from pmns and tnfα from macrophages [1].
in vivo
animal study found that the iv injection of 6-oau was able to raise the blood cxcl1 level in rats. in addition, the inoculation of 6-oau into the rat air pouch could accumulate pmns and macrophages in the site [1].
IC 50
ERK
References
[1] suzuki, m. ,takaishi, s.,nagasaki, m., et al. medium-chain fatty acid-sensing receptor, gpr84, is a proinflammatory receptor. the journal of biological chemisty 288(15), 10684-10691 (2013).
6-(octylaMino)pyriMidine-2,4(1H,3H)-dione Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
View Lastest Price from 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | 6-OAU
83797-69-7
|
US $163.00-347.00 / mg | 99.68% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-09-06 | 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione
83797-69-7
|
US $1.00 / KG | 1KG | 98% | 20kg | Career Henan Chemical Co |
-
- 6-OAU
83797-69-7
- US $163.00-347.00 / mg
- 99.68%
- TargetMol Chemicals Inc.
-
- 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione
83797-69-7
- US $1.00 / KG
- 98%
- Career Henan Chemical Co