3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone
![3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone Structure](CAS/20180703/GIF/1290541-46-6.gif)
- CAS No.
- 1290541-46-6
- Chemical Name:
- 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone
- Synonyms
- BO2;B02;CS-2461;RAD51 Inhibitor B02;RAD51 Inhibitor B02 >=98% (HPLC);RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem;(E)-3-benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one;3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone;4(3H)-Quinazolinone, 3-(phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-;Apoptosis,RAD-51 Inhibitor B02,B-02,B 02,RAD51,RAD51 Inhibitor B02,Inhibitor,inhibit
- CBNumber:
- CB82751056
- Molecular Formula:
- C22H17N3O
- Molecular Weight:
- 339.39
- MDL Number:
- MFCD03294274
- MOL File:
- 1290541-46-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0364 | RAD51 Inhibitor B02 ≥98% (HPLC) | 1290541-46-6 | 5mg | $158 | 2024-03-01 | Buy |
| Sigma-Aldrich | 553525 | RAD51 Inhibitor, B02 | 1290541-46-6 | 25mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 22133 | RAD51 Inhibitor B02 ≥98% | 1290541-46-6 | 5mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 22133 | RAD51 Inhibitor B02 ≥98% | 1290541-46-6 | 10mg | $68 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0364 | RAD51 Inhibitor B02 ≥98% (HPLC) | 1290541-46-6 | 25mg | $378.6 | 2024-03-01 | Buy |
3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone Chemical Properties,Uses,Production
Uses
3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone is an inhibitor of human RAD51. RAD51 is involved in DNA repair and small molecules that inhibits RAD51 may be used to improve the efficacy of chemotherapy.
Uses
RAD51 Inhibitor B02 has been used:
- to test its effect on the polar body extrusion (PBE) rate in porcine oocytes
- for RAD51 inhibition in porcine embryos
- as RAD51 inhibitor and to test its effect on targeted nucleotide substitution (TNS) in induced pluripotent stem cells (iPSCs)
Definition
ChEBI: 3-(phenylmethyl)-2-[2-(3-pyridinyl)ethenyl]-4-quinazolinone is a member of quinazolines.
General Description
A cell-permeable pyridinylvinyl-quinazolinone compound that is shown to specifically inhibit human RAD51 (IC50 = 27.4 μM). Does not affect RecA even at much higher concentration (~250 μM). Directly interacts with RAD51 (Kd = 5.6 μM), and disrupts its binding to DNA and nucleoprotein filament formation. Blocks double-strand break-induced homologous recombination and enhances sensitivity of cells to Cisplatin (Cat. No. 232120) and Mitomycin C (Cat. No. 47589), (Cat. No. 475820). Diminishes co-aggregate formation between RAD51-ssDNA filament and dsDNA. RAD51-Stimulatory Compound-1, RS-1 (Cat. No. 553510) is also available.
Biochem/physiol Actions
B02 (3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone), a pyridinylvinyl-quinazolinone compound is cell-permeable. B02 inhibits human RAD51 recombinase and subsequent nucleofilaments formation. It halts homologous recombination (HR) repair events in cancer cells. B02 favors apoptosis in multiple myeloma and is crucial for sensitizing them to doxorubicin.
storage
Store at +4°C
3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30240 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
View Lastest Price from 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | RAD51 Inhibitor B02
1290541-46-6
|
US $41.00-98.00 / mg | 99.89% | 10g | TargetMol Chemicals Inc. |
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- RAD51 Inhibitor B02
1290541-46-6
- US $41.00-98.00 / mg
- 99.89%
- TargetMol Chemicals Inc.