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Acid Red 94

CAS No.
632-69-9
Chemical Name:
Acid Red 94
Synonyms
ROSE BENGAL;RB;BENGAL ROSE;ROSE BENGAL SODIUM SALT;ROSE BENGAL DISODIUM SALT;ROSE BENGALE;CI 45440;Rose red;TNF-α ELISA;4,5,6,7-tetrachloro-2’,4’,5’,7’-tetraiodo-fluoresceidisodiumsalt
CBNumber:
CB8300775
Molecular Formula:
C20H5Cl4I4NaO5
Molecular Weight:
997.66
MDL Number:
MFCD00151169
MOL File:
632-69-9.mol
MSDS File:
SDS
Last updated:2024-12-18 14:15:32

Acid Red 94 Properties

Melting point >300°C
storage temp. Store at +15°C to +30°C.
solubility H2O: soluble1mg/mL
Colour Index 45440
form Solid
pka 3.9, 4.7(at 25℃)
color Red-brown
Water Solubility soluble
Sensitive Light Sensitive
λmax 548 nm
Merck 14,8262
BRN 3645857
Biological Applications Apoptosis assay; diagnosis of diseases related to amyloid accumulation; controlling plant diseases; identifying fungi; treating skin,mouth,digestive tract,urinary tract,reproductive tract,respiratory tract,circulatory system
CAS DataBase Reference 632-69-9(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 956575SN5L
ATC code S01JA02
EPA Substance Registry System Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-, disodium salt (632-69-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Warning
Hazard statements  H290
Precautionary statements  P234-P390
Hazard Codes  Xi
Risk Statements  36-36/38
Safety Statements  22-24/25-37/39-26
RIDADR  UN 3264 8 / PGIII
WGK Germany  3
RTECS  LM5920000
8
TSCA  Yes
HS Code  32129000
NFPA 704
0
2 0

Acid Red 94 price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich RAB1898 Rat E-Selectin ELISA for serum, plasma and cell culture supernatants 96WELLS $869 2024-03-01 Buy
Sigma-Aldrich RAB1187 Bovine IGF-1 ELISA for serum, plasma and cell culture supernatants 632-69-9 96wells $635 2024-03-01 Buy
Sigma-Aldrich 198250 Rose bengal certified by the Biological Stain Commission, Dye content ≥80% 632-69-9 5g $35.3 2024-03-01 Buy
Sigma-Aldrich 198250 Rose bengal certified by the Biological Stain Commission, Dye content ≥80% 632-69-9 25g $119 2024-03-01 Buy
TCI Chemical F0001 Food Red No. 105 632-69-9 25g $144 2024-03-01 Buy
Product number Packaging Price Buy
RAB1898 96WELLS $869 Buy
RAB1187 96wells $635 Buy
198250 5g $35.3 Buy
198250 25g $119 Buy
F0001 25g $144 Buy

Acid Red 94 Chemical Properties,Uses,Production

Description

Rose bengal is a xanthene dye, fluorescein derivative, and photosensitizer. It exhibits absorption/emission maxima of 548/567 nm, respectively. Rose bengal binds to S. aureus cells and decreases survival of photoirradiated S. aureus to 0.012% when used at a concentration of 1 μM. It generates singlet oxygen when exposed to photoirradiation in cell-free assays and induces potassium ion leakage from S. aureus and bovine erythrocytes in the presence of photoirradiation. Rose bengal inhibits the cytochrome P450 (CYP) isoform CYP3A4/5 and the UDP-glucuronosyltransferase (UGT) isoform UGT1A6 in human liver microsomes in a light-dependent manner, with IC50 values of 0.072 and 0.035 μM, respectively, in yellow light, 3.1 and 4.2 μM, respectively, in ambient light, and 3 and 4.2 μM, respectively, in the dark. It has been used for staining of live cells, but exhibits both intrinsic and phototoxicity.

Chemical Properties

bordeaux-red to red-brown crystalline powder

Uses

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Uses

Rose Bengal Sodium Salt is used in biological studies as potential for use as sensitizers in photodynamic and sonodynamic therapy by synthesizing Rose Bengal amphiphilic derivatives. This compound has neuroprotective properties.

General Description

This ELISA antibody pair detects Bovine IGF-1

Safety Profile

An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits toxic fumes of Cl-, I-, and NazO.

Veterinary Drugs and Treatments

Rose bengal is a vital stain and stains dead epithelial cells and mucus. Full thickness loss of the corneal epithelium is not necessary (only dead cells need be present) to obtain rose bengal stain uptake. It does not stain epithelial defects and does not pass into intercellular spaces.
Rose bengal stain is most commonly employed in the detection of the presence of viral keratitis in the cat. Because feline herpes virus tends to infect one cell, moving then to an adjacent cell (causing the so called dendritic tracts in the cornea) without full thickness loss of corneal epithelium initially, rose bengal is an ideal diagnostic agent for this infection. Rose Bengal can also be used to detect damaged corneal epithelium on the dorsal cornea in early cases of keratoconjunctivitis sicca. Rose bengal stain is virucidal although no information is available relative to its use as a therapeutic agent.

in vitro

rose bengal was a quite potent membrane-permeant inhibitor of glutamate uptake into isolated synaptic vesicles. such vesicular glu uptake inhibition was achieved without affecting h1-pump atpase. it was found that various degrees of reduction elicited by rose bengal in [3h]glu in synaptic vesicles inside the synaptosome [1].

in vivo

the distribution of i.v. administered rose bengal was found to depend on its dose. at a low dose, rose bengal could be found almost solely in the liver and plasma. however, at higher doses, the amount of rose bengal found in extra-hepatic tissues gradually increased. the hepatic transfer maximum of rose bengal amounted to 146 micrograms/kg/min. by increasing the dose from 10 to 200 mg/kg, the hepatic concentration of rose bengal also approached a maximum. the storage capacity of the liver, however, did not limit the transfer maximum of rose bengal [1].

storage

Store at RT

Purification Methods

This biological stain can be purified by chromatography on silica TLC using a 35:65 mix of EtOH/acetone as eluent. [Beilstein 19 II 261, 19 III/IV 2926.]

References

[1] ogita k,hirata k,bole dg,yoshida s,tamura y,leckenby am,ueda t. inhibition of vesicular glutamate storage and exocytotic release by rose bengal. j neurochem.2001 apr;77(1):34-42.
[2] fischer e,varga f. hepatic storage and biliary excretion of rose bengal in the rat. acta physiol acad sci hung.1979;54(1):89-94.

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View Lastest Price from Acid Red 94 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Acid Red 94 pictures 2024-12-13 Acid Red 94
632-69-9
US $0.00 / KG 1KG 98% 200kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Rose Bengal sodium pictures 2024-11-17 Rose Bengal sodium
632-69-9
US $64.00-153.00 / mg 91.6% 10g TargetMol Chemicals Inc.
Rose Bengal sodium salt pictures 2024-10-11 Rose Bengal sodium salt
632-69-9
US $5.00-2.00 / KG 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
  • Acid Red 94 pictures
  • Acid Red 94
    632-69-9
  • US $0.00 / KG
  • 98%
  • WUHAN FORTUNA CHEMICAL CO., LTD
4’,5’,7’-tetraiodo-droxy-2disodiumsalt 9-(3’,4’,5’,6’-tetrachloro-o-carboxyphenyl)-6-hydroxy-2,4,5,7-tetraiodo-3-is foodredcolorno.105,sodiumsalt foodredno.105,sodiumsalt oxanthone2na r105sodium rosebengalsodium Rozebengal,sodiumsalt Tetrachlorotetraiodofluorescein,disodiumsalt 4,5,6,7-TETRACHLORO-2',4',5',7'-TETRAIODOFLUORESCEIN SODIUM SALT BENGAL ROSE B SODIUM SALT BENGAL ROSE B ANILINE ROSE CI NO 45440 CI NO 45435 CI 45435 CI 45440 SODIUM SALT FOOD RED NO 105 TETRACHLOROTETRAIODOFLUORESCEIN SODIUM SALT TETRAIODOTETRACHLOROFLUORESCEIN DISODIUM SALT SODIUM TETRAIODODICHLOROFLUORESCEIN ROSE BENGAL B ROSE BENGAL 3B, CONC ROSE BENGAL G ACID RED 94 ACID RED 94 SODIUM SALT disodium 3,4,5,6-tetrachloro-2-(2,4,5,7-tetraiodo-6-oxido-3-oxoxanthen-9-yl)benzoate B RHODAMINE B dog IL-2 ELISA dog IL-4 ELISA dog MMP-9 ELISA dog sICAM-1 ELISA dog TGF-βELISA dog VCAM-1 ELISA E-Cadherin ELISA ENA-78 ELISA Eotaxin ELISA goat IFN-γELISA goat IL-1βELISA Guinea Pig GM-CSF ELISA Guinea Pig Histamine ELISA Guinea Pig IFN-γ ELISA Guinea pig IgE ELISA Guinea Pig IL-1 ELISA Guinea Pig IL-2 ELISA Guinea Pig IL-4 ELISA Guinea Pig IL-5 ELISA Guinea Pig IL-6 ELISA Guinea Pig LTB4 ELISA Guinea Pig PAF ELISA Guinea Pig sICAM-1 ELISA mouse IFN-α ELISA Mouse IgE ELISA Mouse IGF-1 ELISA mouse IL-11 ELISA Mouse Inhibin-B ELISA mouse OxLDL ELISA mouse SCD40L ELISA