ChemicalBook >> CAS DataBase List >>RO8994
RO8994
- CAS No.
- 1309684-94-3
- Chemical Name:
- RO8994
- Synonyms
- RO8994;CS-2264;RO-8994;RO 8994;RO8994;RO-8994;RO 8994;(2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-;(2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-;(2'S,3R,4'S,5'R)-N-[4-(Aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide;Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-;E2 conjugating enzyme,MDM-2/p53,Ubiquitin conjugating enzyme,Ubiquitin activating enzyme,E3 ligating enzyme,RO8994,inhibit,Inhibitor,RO 8994,RO-8994,E1/E2/E3 Enzyme,E1 activating enzyme,Ubiquitin ligase
- CBNumber:
- CB83041727
- Molecular Formula:
- C31H31Cl2FN4O4
- Molecular Weight:
- 613.51
- MDL Number:
- MFCD29472243
- MOL File:
- 1309684-94-3.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:24
Boiling point | 753.5±60.0 °C(Predicted) |
---|---|
Density | 1.41±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility |
DMF:12.5(Max Conc. mg/mL);20.4(Max Conc. mM) DMSO:14.0(Max Conc. mg/mL);22.8(Max Conc. mM) Ethanol:5.0(Max Conc. mg/mL);8.1(Max Conc. mM) |
form | A crystalline solid |
pka | 12.00±0.70(Predicted) |
color | White to off-white |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
RO8994 price More Price(14)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 25674 | RO8994 | 1309684-94-3 | 1mg | $68 | 2024-03-01 | Buy |
Cayman Chemical | 25674 | RO8994 | 1309684-94-3 | 25mg | $1169 | 2024-03-01 | Buy |
Cayman Chemical | 25674 | RO8994 | 1309684-94-3 | 5mg | $286 | 2024-03-01 | Buy |
Cayman Chemical | 25674 | RO8994 | 1309684-94-3 | 10mg | $535 | 2024-03-01 | Buy |
TRC | R637390 | RO8994 | 1309684-94-3 | 2.5mg | $200 | 2021-12-16 | Buy |
RO8994 Chemical Properties,Uses,Production
Description
RO8994 is an inhibitor of the protein-protein interaction between MDM2 and the tumor suppressor p53 in a homogeneous time-resolved fluorescence (HTRF) binding assay (IC50 = 5 nM). It inhibits the proliferation of SJSA-1, RKO, and HCT116 cells with an average IC50 value of 20 nM and increases apoptosis in SJSA-1 cells in a concentration-dependent manner. RO8994 reduces tumor growth and induces tumor regression in an SJSA-1 osteosarcoma mouse xenograft model when administered at doses of 1.56 and 6.25 mg/kg, respectively.
Uses
RO 8994 is a potent and selective spiroindolinone MDM2 inhibitor, and potential useful for cancer therapy.
Synthesis of RO8994 from Benzoic acid, 4-[(2-aminoacetyl)amino]-3-methoxy-, methyl ester, hydrochloride (1:1)
RO8994 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 54)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32835 | 60 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3600 | 58 |
Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 |
RO8994
(2'S,3R,4'S,5'R)-N-[4-(Aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide
Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-
RO-8994;RO 8994
RO8994;RO-8994;RO 8994
CS-2264
E2 conjugating enzyme,MDM-2/p53,Ubiquitin conjugating enzyme,Ubiquitin activating enzyme,E3 ligating enzyme,RO8994,inhibit,Inhibitor,RO 8994,RO-8994,E1/E2/E3 Enzyme,E1 activating enzyme,Ubiquitin ligase
(2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-
(2'S,3R,4'R,5'R)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-
1309684-94-3
C31H31Cl2FN4O4