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Methyl 2-phenylacetoacetate

CAS No.
16648-44-5
Chemical Name:
Methyl 2-phenylacetoacetate
Synonyms
BMK Glycidate;Benzeneacetic;Methyl 3-oxo-2-phenylbutanoate;BMK glycidate oil;Benzeneacetic acid, a-acetyl-, methyl ester;PBMK;BMK PRICE;bmk factory;bmk white powder;BMK CHINA FACTORY
CBNumber:
CB83067497
Molecular Formula:
C11H12O3
Molecular Weight:
192.21
MDL Number:
MFCD21881652
MOL File:
16648-44-5.mol
MSDS File:
SDS
Last updated:2023-05-09 09:30:52

Methyl 2-phenylacetoacetate Properties

Melting point 58.5-59.0 °C
Boiling point 92-96 °C(Press: 0.6 Torr)
Density 1?+-.0.06 g/cm3(Predicted)
solubility DMF: 30 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 50 mg/ml; Methanol: 1 mg/ml
form A crystalline solid
pka 10.67±0.46(Predicted)
FDA UNII 2TG7ZF9DBT

Methyl 2-phenylacetoacetate Chemical Properties,Uses,Production

Uses

Benzeneacetic acid, a-acetyl-, methyl ester can be used as a pharmaceutical raw material.

Description

Methyl 2-phenylacetoacetate is an analytical reference standard categorized as a precursor in the synthesis of amphetamines and methamphetamines. This product is intended for research and forensic applications.
The Drug Enforcement Administration is proposing the control of the chemical methyl alpha-phenylacetoacetate (also known as MAPA; methyl 3-oxo-2-phenylbutanoate; methyl 2-phenylacetoacetate; [alpha]-acetyl-benzeneacetic acid, methyl ester; and CAS Number: 16648-44-5) and its optical isomers as a list I chemical under the Controlled Substances Act (CSA). Methyl alpha-phenylacetoacetate is used in clandestine laboratories to illicitly manufacture the schedule II controlled substances phenylacetone (also known as phenyl-2-propanone or P2P), methamphetamine, and amphetamine and is important to the manufacture of these controlled substances.

Description

Methyl 2-phenylacetoacetate (Item No. 28352) is an analytical reference standard categorized as a precursor in the synthesis of amphetamines and methamphetamines. This product is intended for research and forensic applications.

Uses

D1, D2 dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic. Droperidol is a potent antagonist of dopamine subtype 2 receptor. It is an antipsychotic, which is used to treat acute behavioral anomalies. It helps to manage postoperative nausea and vomiting. Endogenous κ1b opioid receptor agonist.

Preparation

Methyl phenyldiazoacetate, precursor to cyclopropanation agents, is prepared by treating methyl phenylacetate with p-acetamidobenzenesulfonyl azide in the presence of base.

Methyl 2-phenylacetoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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