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I-BRD9

CAS No.
1714146-59-4
Chemical Name:
I-BRD9
Synonyms
I-BRD9;GSK602;CS-2328;I-BRD9;I-BRD-9;I-brd9 GSK602;N-(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-5-ethyl-4-oxo-7-(3-(trifluoromethyl)phenyl)-4,5-di;N-(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-5-ethyl-4-oxo-7-(3-(trifluoromethyl)phenyl)-4,5-dihydrothieno[3,2-c]pyridine-2-carboximidamide;5-Ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide;Thieno[3,2-c]pyridine-2-carboximidamide, 5-ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]-
CBNumber:
CB83122929
Molecular Formula:
C22H22F3N3O3S2
Molecular Weight:
497.55
MDL Number:
MFCD28952791
MOL File:
1714146-59-4.mol
Last updated:2024-11-19 20:33:22

I-BRD9 Properties

Boiling point 683.9±65.0 °C(Predicted)
Density 1.50±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form crystalline solid
pka 9.35±0.40(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

I-BRD9 price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17749 I-BRD9 ≥98% 1714146-59-4 1mg $73 2024-03-01 Buy
Cayman Chemical 17749 I-BRD9 ≥98% 1714146-59-4 5mg $144 2024-03-01 Buy
Cayman Chemical 17749 I-BRD9 ≥98% 1714146-59-4 10mg $231 2024-03-01 Buy
Cayman Chemical 17749 I-BRD9 ≥98% 1714146-59-4 50mg $967 2024-03-01 Buy
Tocris 5591 I-BRD9 ≥98%(HPLC) 1714146-59-4 10 $225 2021-12-16 Buy
Product number Packaging Price Buy
17749 1mg $73 Buy
17749 5mg $144 Buy
17749 10mg $231 Buy
17749 50mg $967 Buy
5591 10 $225 Buy

I-BRD9 Chemical Properties,Uses,Production

Description

I-BRD9 is a selective cellular chemical probe for bromodomain-containing protein 9 (BRD9). I-BRD9 has a pIC50 value of 7.3 for BRD9 inhibitor, with greater than 700-fold selectivity over the BET family and 200-fold over the highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 is also shows a greater than 70-fold selectivity against a panel of 34 bromodomains. I-BRD9 downregulates CLEC1, DUSP6, FES and SAMSN1 genes in Kasumi-1 cells.

Uses

I-BRD9 is a bromodomain-containing protein 9 (BRD9) inhibitor which belong to class of (BET) inhibitors that have shown potent anti-inflammatory and anticancer properties.

Biological Activity

pic50: 7.3i-brd9 is a brd9 inhibitor.brd9 is identified as a bromodomain containing protein forming a small sub-branch of the bromodomain family tree. human brd9 has a single bromodomain and contains five isoforms which are produced by alternative splicing.

in vitro

in previous study, the i-brd9 development was driven by iterative medicinal chemistry, using structure based design to result in nanomolar potency at brd9, over 700-fold selectivity against the bet family as well as more than 70-fold to a panel of 34 bromodomains. in kasumi-1 cells, i-brd9 could downregulate dusp6, clec1, samsn1 and fes genes. moreover, i-brd9 was used to expore genes regulated by brd9 in kasumi-1 cells involved in immune response and oncology pathways. in addition, when brd4 was used as a representative member of the bet family for initial selectivity screening, i-brd9 was found to have a pic50 of 5.3 against this protein. i-brd9 thus represented the first available selective tool compound to investigate the cellular phenotype of the inhibition of brd9 bromodomain [1].

storage

Store at -20°C

References

[1] theodoulou nh et al. discovery of i-brd9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition. j med chem. 2016 feb 25;59(4):1425-39.

I-BRD9 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 98)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32957 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8467 58
Jilin Chinese Academy of Sciences-yanshen Technology
+undefined18143011203 info@chemextension.com China 42056 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58

View Lastest Price from I-BRD9 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
I-BRD9 pictures 2024-11-19 I-BRD9
1714146-59-4
US $34.00-68.00 / mg 99.28% 10g TargetMol Chemicals Inc.
  • I-BRD9 pictures
  • I-BRD9
    1714146-59-4
  • US $34.00-68.00 / mg
  • 99.28%
  • TargetMol Chemicals Inc.
I-BRD9 I-brd9 GSK602 GSK602 N-(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-5-ethyl-4-oxo-7-(3-(trifluoromethyl)phenyl)-4,5-di 5-Ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide I-BRD9;I-BRD-9 CS-2328 Thieno[3,2-c]pyridine-2-carboximidamide, 5-ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]- N-(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-5-ethyl-4-oxo-7-(3-(trifluoromethyl)phenyl)-4,5-dihydrothieno[3,2-c]pyridine-2-carboximidamide 1714146-59-4 C22H22F3N3O3S2 API