CZ415
- CAS No.
- 1429639-50-8
- Chemical Name:
- CZ415
- Synonyms
- CZ415;CS-2392;CZ 415;CZ-415;CZ415 (Free base);CZ415, 10 mM in DMSO;inhibit,Inhibitor,mTOR,CZ415,CZ-415,CZ 415,Mammalian target of Rapamycin;(S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea;Urea, N-[4-[5,7-dihydro-7,7-dimethyl-4-[(3S)-3-methyl-4-morpholinyl]-6,6-dioxidothieno[3,4-d]pyrimidin-2-yl]phenyl]-N'-ethyl-
- CBNumber:
- CB83146695
- Molecular Formula:
- C22H29N5O4S
- Molecular Weight:
- 459.56
- MDL Number:
- MFCD30533321
- MOL File:
- 1429639-50-8.mol
| Boiling point | 611.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.287±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:73.67(Max Conc. mg/mL);160.3(Max Conc. mM) DMSO:PBS (pH 7.2) (1:6):0.1(Max Conc. mg/mL);0.22(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);65.28(Max Conc. mM) Ethanol:10.0(Max Conc. mg/mL);21.76(Max Conc. mM) |
| form | A crystalline solid |
| pka | 13.79±0.46(Predicted) |
| color | White to off-white |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H335-H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| NFPA 704 |
|
CZ415 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27668 | CZ415 | 1429639-50-8 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 27668 | CZ415 | 1429639-50-8 | 25mg | $586 | 2024-03-01 | Buy |
| Cayman Chemical | 27668 | CZ415 | 1429639-50-8 | 5mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 27668 | CZ415 | 1429639-50-8 | 10mg | $321 | 2024-03-01 | Buy |
| TRC | C998985 | CZ415 | 1429639-50-8 | 2.5mg | $210 | 2021-12-16 | Buy |
CZ415 Chemical Properties,Uses,Production
Description
CZ415 is an inhibitor of mammalian target of rapamycin (mTOR; Kd = 6.3 nM). It is 1,000-fold selective for mTOR over a panel of 285 kinases. CZ415 inhibits phosphorylation of S6 ribosomal protein (S6RP) and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively). It inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM). CZ415 (10 mg/kg) reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis. It also inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model when administered at a dose of 20 mg/kg.
Uses
CZ415 is a selective and potent ATP-competitive mTOR inhibitor (1). It demonstrated in vivo efficacy in a semitherapeutic collagen induced arthritis (CIA) mouse model.
in vivo
CZ415 is a highly selective mTOR inhibitor showing in vivo efficacy in a collagen induced arthritis (CIA) model. For full characterization of CZ415 and to enable improved dose predictions, the pharmacokinetic (PK) profile is assessed in rat. PK and oral bioavailability are determined after of 1 mg/kg intravenous (iv) bolus and 3 mg/kg oral (po) administration. The observed plasma clearance, corresponding to 45% liver blood flow, suggests that sufficient levels of free compound are circulating in the animal over time. The oral uptake is rapid with a Tmaxmax of 0.5 h and bioavailability F = 44% indicates very good absorption from the gut[1].
IC 50
mTOR: 8.07 (pIC50); mTORC1; mTORC2
CZ415 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |