RN-1 (hydrochloride)
- CAS No.
- 1781835-13-9
- Chemical Name:
- RN-1 (hydrochloride)
- Synonyms
- RN1; RN 1;RN-1 (hydrochloride);RN 1 dihydrochloride;1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride;disease,RN1,RN 1 dihydrochloride,Histone Demethylase,inhibit,hemoglobin,fetal,RN1 dihydrochloride,brain-penetrant,LSD1,Inhibitor,HbF,sickle,RN 1,cell,RN-1,irreversible
- CBNumber:
- CB83152731
- Molecular Formula:
- C23H30ClN3O2
- Molecular Weight:
- 415.96
- MDL Number:
- MFCD32200435
- MOL File:
- 1781835-13-9.mol
RN-1 (hydrochloride) price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18124 | RN-1 (hydrochloride) ≥95% | 1781835-13-9 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 18124 | RN-1 (hydrochloride) ≥95% | 1781835-13-9 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 18124 | RN-1 (hydrochloride) ≥95% | 1781835-13-9 | 10mg | $216 | 2024-03-01 | Buy |
| Tocris | 4977 | RN1dihydrochloride ≥97%(HPLC) | 1781835-13-9 | 10 | $223 | 2021-12-16 | Buy |
| Tocris | 4977 | RN1dihydrochloride ≥97%(HPLC) | 1781835-13-9 | 50 | $936 | 2021-12-16 | Buy |
RN-1 (hydrochloride) Chemical Properties,Uses,Production
Uses
RN-1 Hydrochloride is a potent, irreversible inhibitor of LSD1. It blocks long-term but not short-term memory in mice following intraperitoneal administration. RN-1 also induces cytotoxicity in ovarian cancer cell lines and induces fetal hemoglobin synthesis while reducing disease pathology in sickle cell mice.
Biological Activity
rn-1 (hydrochloride) is a brain-penetrant, potent and irreversible lsd1 inhibitor with ic50 values of 10-70 nm [1].lysine-specific demethylase 1 (lsd1) is a flavin-dependent monoamine oxidase that demethylate mono- and di-methylated lysines, specifically histone 3, lysines 4 and 9 (h3k4 and h3k9) [2].rn-1 (hydrochloride) is a potent and irreversible lsd1 inhibitor with ic50 values of 10-70 nm. however, rn-1 is much less effective against mao-a and mao-b with ic50 values of 0.51 and 2.785 μm, respectively [1]. in ovarian cancer lines, rn-1 also induced cytotoxicity, which was correlated with the lsd1 inhibitory potential [3].following intraperitoneal administration in mice, rn-1 penetrated the blood-brain barrier and the brain/plasma exposure ratio was 88.9. in mice, rn-1 significantly impaired long-term memory but not short-term memory. and long-term memory impairment was due to a brain-specific effect [1]. in a sickle cell disease (scd) mouse model, rn-1 induced hbf synthesis and increased frequencies of hbf-positive cells and mature erythrocytes, as well as reduced reticulocytes and sickle cells. and the rn-1 treated mice did not exhibit the necrotic lesions in the liver and spleen [4].
storage
Store at -20°C
References
[1]. neelamegam r, ricq el, malvaez m, et al. brain-penetrant lsd1 inhibitors can block memory consolidation. acs chem neurosci. 2012 feb 15;3(2):120-128.
[2]. shi y, lan f, matson c, et al. histone demethylation mediated by the nuclear amine oxidase homolog lsd1. cell. 2004 dec 29;119(7):941-53.
[3]. konovalov s, garcia-bassets i. analysis of the levels of lysine-specific demethylase 1 (lsd1) mrna in human ovarian tumors and the effects of chemical lsd1 inhibitors in ovarian cancer cell lines. j ovarian res. 2013 oct 29;6(1):75.
[4]. cui s, lim kc, shi l, et al. the lsd1 inhibitor rn-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. blood. 2015 jul 16;126(3):386-96.
RN-1 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
RN-1 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6008 | 61 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4287 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8017 | 62 |