ASB14780
- CAS No.
- 1069046-00-9
- Chemical Name:
- ASB14780
- Synonyms
- ASB14780;ASB 14780New;ASB 14780 (ASB14780;ASB14780 >=98% (HPLC)
- CBNumber:
- CB83159376
- Molecular Formula:
- C35H38N2O6
- Molecular Weight:
- 582.7
- MDL Number:
- MFCD30749241
- MOL File:
- 1069046-00-9.mol
ASB14780 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 6316 | ASB14780 ≥98%(HPLC) | 1069046-00-9 | 5 | $125 | 2021-12-16 | Buy |
| Axon Medchem | Axon2578 | ASB14780 99% | 1069046-00-9 | 10mg | $132 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004671 | ASB-14780 95.00% | 1069046-00-9 | 5MG | $503.1 | 2021-12-16 | Buy |
ASB14780 Chemical Properties,Uses,Production
Description
ASB14780 is a potent inhibitor of cPLA2α.
Uses
ASB14780 is a 4-phenoxy derivative, the cytosolic Phospholipase A2α (cPLA2α) inhibitor, with an IC50 value of 20 nM[1].
in vivo
TPA (tetradecanoyl phorbol acetate) causes acute inflammation with ear, resulting in edema[1].
ASB14780 (50 mg/kg; p.o.; once) suppresses the increase in the ear thickness elicited by the application of TPA (tetradecanoyl phorbol acetate) in mouse[1].
ASB14780 (5 mg/kg; 20 mg/kg; p.o.; once daily) attenuates AHR (airway hyperreactivity), and inhibits IAR (immediate asthmatic response) and LAR (late asthmatic response) in a dose-dependent manner[1].
ASB14780 shows well oral activity of 89.6% in mouse calculated from the ratio of oral administration’s AUC (10 mg/kg; p.o.) and intravenonous administration’s AUC (1 mg/kg; i.v.)[1].
Oral Bioavailabilities and Pharmacokinetic Parameters of ASB14780[1]
| Model | F (%) | AUC (h μg/mL) | Cmax (μg/mL) |
| mouse | 89.6 | 7.12 | 5.12 |
| dog | 34.3 | 17.1 | 4.96 |
| monkey | 30.9 | 4.96 | 2.29 |
| Animal Model: | TPA (Tetradecanoyl Phorbol Acetate)-induced Ear Edema Model in mouse (female C57BL/6 mice)[1] |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage; 30 min before TPA stimulation |
| Result: | Showed high potency and inhibited ear swelling by 30% and indicated the in vivo anti-inflammatory activity. |
| Animal Model: | Guinea Pig Ovalbumin (OVA)-induced Asthma Model[1] |
| Dosage: | 5 mg/kg, 20 mg/kg |
| Administration: | Oral gavage; two single doses; 1 h before and 8 h after passively sensitized administration |
| Result: | Exhibits suppression on IAR (immediate asthmatic response) and LAR (late asthmatic response) in a dose-dependent manner. |
storage
Store at -20°C
References
[1] Tomoo T, et al. Design, synthesis, and biological evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2α inhibitors. J Med Chem. 2014. 57(17):7244-62. DOI:10.1021/jm500494y
ASB14780 Preparation Products And Raw materials
Raw materials
Preparation Products
ASB14780 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44814 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4997 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24683 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5237 | 58 |
| R&D Systems, Inc | 18003437475 18003437475 | rdname@qq.com | China | 35960 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 292394 | 58 |
