Seletalisib
- CAS No.
- 1362850-20-1
- Chemical Name:
- Seletalisib
- Synonyms
- UCB5857;Seletalisib;UCB-5857;UCB5857;Seletalisib(UCB-5857);Seletalisib, 10 mM in DMSO;UCB5857; UCB-5857; UCB 5857;Inhibitor,Phosphoinositide 3-kinase,Seletalisib,UCB-5857,UCB 5857,inhibit,PI3K;(R)-3-(8-Chloro-3-(2,2,2-trifluoro-1-(pyrido[3,2-d]pyrimidin-4-ylamino)ethyl)quinolin-2-yl)pyridine 1-oxide;Pyrido[3,2-d]pyrimidin-4-amine, N-[(1R)-1-[8-chloro-2-(1-oxido-3-pyridinyl)-3-quinolinyl]-2,2,2-trifluoroethyl]-
- CBNumber:
- CB83171699
- Molecular Formula:
- C23H14ClF3N6O
- Molecular Weight:
- 482.85
- MDL Number:
- MFCD28963973
- MOL File:
- 1362850-20-1.mol
| Boiling point | 710.8±60.0 °C(Predicted) |
|---|---|
| Density | 1.53±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 83.3 mg/mL (172.52 mM) |
| form | Solid |
| pka | 3.55±0.30(Predicted) |
| color | White to off-white |
| FDA UNII | 64CW205BDD |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Seletalisib price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-6470 | Seletalisib 98.50% | 1362850-20-1 | 1mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-6470 | Seletalisib 98.50% | 1362850-20-1 | 5mg | $260 | 2021-12-16 | Buy |
| ChemScene | CS-6470 | Seletalisib 98.50% | 1362850-20-1 | 10mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-6470 | Seletalisib 98.50% | 1362850-20-1 | 50mg | $1250 | 2021-12-16 | Buy |
| ChemScene | CS-6470 | Seletalisib 98.50% | 1362850-20-1 | 100mg | $2100 | 2021-12-16 | Buy |
Seletalisib Chemical Properties,Uses,Production
Uses
Seletalisib (UCB5857) is potent and selective PI3Kδ inhibitor with an IC50 of 12 nM.
in vivo
Seletalisib significantly inhibits IL-2 release following TCR stimulation in the rat. The inhibition is observed at all tested doses of seletalisib with almost complete inhibition reached at dose levels ≥1 mg/kg. Seletalisib has potent in vivo effects with an estimated IC50 value of <10 nM[1].
IC 50
PI3Kδ: 12 nM (IC50)
References
[1] Allen RA, et al. Seletalisib: Characterization of a Novel, Potent, and Selective Inhibitor of PI3Kδ. J Pharmacol Exp Ther. 2017 Apr 25. pii: jpet.116.237347. DOI:10.1124/jpet.116.237347
Seletalisib Preparation Products And Raw materials
Raw materials
Preparation Products
Seletalisib Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30231 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 0-1502103-5486 18017383231 | 983544897@qq.com | China | 9347 | 55 |
View Lastest Price from Seletalisib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Seletalisib
1362850-20-1
|
US $52.00-198.00 / mg | 99.81% | 10g | TargetMol Chemicals Inc. |
-
- Seletalisib
1362850-20-1
- US $52.00-198.00 / mg
- 99.81%
- TargetMol Chemicals Inc.