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ChemicalBook >> CAS DataBase List >>1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Structure
1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER structure
CAS No.
53554-29-3
Chemical Name:
1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER
Synonyms
BUTTPARK;AvafilImpurity32;BUTTPARK 21\07-73;RSYY(Apremilast)-4;Avanafil Impurity 86;1,4-Dihydro-2-(methylthio)-4-oxo-5;1,4-DHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE;1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-;4-hydroxy-2-methylthiopyrimidine-5-ethyl formate;Ethyl 4-hydroxy-2-methylthio-5-pyrimidinecarboxylate
CBNumber:
CB8337586
Molecular Formula:
C8H10N2O3S
Molecular Weight:
214.24
MDL Number:
MFCD03002357
MOL File:
53554-29-3.mol
MSDS File:
SDS
Last updated:2024-11-12 17:13:25
Request For Quotation

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Properties

Melting point 136-144°C
Density 1.37±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka 6.48±0.50(Predicted)
CAS DataBase Reference 53554-29-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
HazardClass  IRRITANT
HS Code  2933599590

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S376523 ETHYL 4-HYDROXY-2-METHYLTHIO-5-PYRIMIDINECARBOXYLATE Aldrich 53554-29-3 250mg $179 2024-03-01 Buy
TRC D492223 1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-carboxylateacidethylester 53554-29-3 250mg $55 2021-12-16 Buy
TRC D492223 1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-carboxylateacidethylester 53554-29-3 1g $75 2021-12-16 Buy
Matrix Scientific 066838 Ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate 84% 53554-29-3 5g $121 2021-12-16 Buy
Apolloscientific OR0875 Ethyl1,4-dihydro-2-(methylthio)-4-oxopyrimidine-5-carboxylate 53554-29-3 1g $15 2021-12-16 Buy
Product number Packaging Price Buy
S376523 250mg $179 Buy
D492223 250mg $55 Buy
D492223 1g $75 Buy
066838 5g $121 Buy
OR0875 1g $15 Buy

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Chemical Properties,Uses,Production

Uses

1,4-Dihydro-2-methylmercapto-4-oxo-5-pyrimidinecarboxylic acid ethyl ester can be used as several synthetic intermediates and pharmaceutical intermediates, mainly used in laboratory research and development process and pharmaceutical and chemical production process.

Synthesis

Methylthiourea sulfate (75.2g, 0.4mol) was added to 16% NaOH (250mL, 1.18mol) solution and stirred for 30min, then diethyl ethoxymethylenemalonate (103.4g, 0.48 mol) was dissolved in 160 mL of ethanol and slowly dropped into the reaction solution. After the dropwise addition was completed, the reaction was carried out at room temperature for 10 h.When a large amount of white solid was precipitated, carry out suction filtration, wash with water, and vacuum dry to obtain a white solid (84.7g, 99.7%); ESE-MS (m/z): 249[M+H]+, 236.9[M+Na]+ , after verification, the product is 1,4-dihydro-2-methylmercapto-4-oxo-5-pyrimidinecarboxylic acid ethyl ester.

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER synthesis

2986-19-8
87-13-8
53554-29-3
Synthesis of 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER from Methyl carbamimidothioate and Diethyl ethoxymethylenemalonate

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Ethanol Acetic anhydride Potassium hydroxide Diethyl ethoxymethylenemalonate Triethyl orthoformate
Sodium Phosphorus oxychloride Benzene 2-Methyl-2-thiopseudourea sulfate Diethyl malonate

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Preparation Products

5-PyriMidinecarboxylic acid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)- 1-pyrrolidinyl]- 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Suppliers

Global( 201)Suppliers
Supplier Tel Email Country ProdList Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.
+86-23-86815286 +86-13983794297 sales@ensky-chemical.com China 92 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 +86-16264648883 niki@zlchemi.com China 864 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29881 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 17322 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
Supplier Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.
58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Accela ChemBio Inc. 		58
Standardpharm Co. Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58

View Lastest Price from 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-carboxylateacidethylester pictures 2024-11-26 1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-carboxylateacidethylester
53554-29-3
 US $10.00 / kg 1kg 99% 20 ton Hebei Zhuanglai Chemical Trading Co Ltd
1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER pictures 2022-11-16 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER
53554-29-3
 US $0.00 / kg 25kg 99% 20 tons TAIZHOU DKD CHEMICAL CO., LTD.
1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-carboxylateacidethylester pictures 2022-09-23 1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-carboxylateacidethylester
53554-29-3
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

53554-29-3(1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER)Related Search:

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER ETHYL 5-PYRIMIDINECARBOXYLATE 98 ETHYL 2-(METHYLSULFANYL)-4-[3-(TRIFLUOROMETHYL)PHENOXY]-5-PYRIMIDINECARBOXYLATE Avanafil Impurity 9 Avanafil Impurity 19
Avanafil Impurity 24 4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine Avanafil Impurity 10 Avanafil Impurity 16 Avanafil Impurity 26
1364671-52-2 5-PyriMidinecarboxylic acid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)- 1-pyrrolidinyl]- Avanafil iMpurity 5 4-((3-Chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic acid Avanafil Impurity 23
Avanafil iMpurity 2 Avanafil Impurity 20 Avanafil Impurity 25

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1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine- 5-PyriMidinecarboxylicacid, 1,6-dihydro-2-(Methylthio)-6-oxo-, ethyl ester Ethyl 2-Methylsulfanyl-6-oxo-1h-pyriMidine-5-carboxylate Ethyl 2-(Methylthio)-6-oxo-1,6-dihydropyriMidine-5-carboxylate 1,4-dihydro-2-Methyl-4-oxo-5-Mercapto-pyriMidine-carboxylic acid ethyl ester Ethyl 2-(methylsulfanyl)-4-oxo-1,4-dihydropyrimidine-5-carboxylate 1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine- 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINECARBOXYLIC ACID ETHYL ESTER >98% 5-PYRIMIDINECARBOXYLICACID,1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-,ETHYLESTER ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate Ethyl 1,4-dihydro-2-(methylthio)-4-oxopyrimidine-5-carboxylate Ethyl 4-hydroxy-2-methylthio-5-pyrimidinecarboxylate Ethyl 1,4-dihydro-2-(methylsulphanyl)-4-oxopyrimidine-5-carboxylate, 1,4-Dihydro-5-(ethoxycarbonyl)-2-(methylthio)-4-oxopyrimidine Ethyl 1,4-dihydro-2-(Methylthio)-4-oxo-5-pyriMidinecarboxylate 4-Hydroxy-2-Methylsulfanyl-pyriMidine-5-carboxylic acid ethyl ester BUTTPARK 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER BUTTPARK 21\07-73 Methyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate 4-hydroxy-2-methylthiopyrimidine-5-ethyl formate Avanafil Impurity 86 Ethyl 2-(methylsulfanyl)-4-oxo-1,4-dihydropyrimidine-5-carbo... 1,4-Dihydro-2-(methylthio)-4-oxo-5 Ethyl 2-thiomethyl-4-hydroxypyrimidine-5-carboxylate AvafilImpurity32 1,4-DHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE RSYY(Apremilast)-4 Ethyl 1,6-dihydro-2-(methylthio)-6-oxo-5-pyrimidinecarboxylate 53554-29-3 pyrimidine