BLASTICIDIN S HYDROCHLORIDE
- CAS No.
- 3513-03-9
- Chemical Name:
- BLASTICIDIN S HYDROCHLORIDE
- Synonyms
- BLASTICIDIN S HCL;Blasticidine S HCl;BLASTICIDIN S 50MG;Miewen S hydrochloride;Blasticidin S (10 mg/ml);BLASTICIDIN S HYDROCHLORIDE;BLASTICIDINE S HYDROCHLORIDE;Blasticidin S (10 mg/mL in Solution);Blasticidine S hydrochloride solution;BLASTICIDIN S HYDROCHLORIDE USP/EP/BP
- CBNumber:
- CB8383972
- Molecular Formula:
- C17H27ClN8O5
- Molecular Weight:
- 458.9
- MDL Number:
- MFCD02091640
- MOL File:
- 3513-03-9.mol
| Melting point | 224-225 °C (decomp) |
|---|---|
| storage temp. | −20°C |
| solubility | Soluble in Water (greater than 25 mg/ml) |
| form | Liquid |
| color | White |
| Water Solubility | Soluble in water. Insoluble in organic solvents. |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 28 | |||||||||
| Safety Statements | 28-36/37-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 1-10 | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
BLASTICIDIN S HYDROCHLORIDE price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 203350 | Blasticidin S, Hydrochloride, Streptomyces griseochromogenes - CAS 589205 - Calbiochem | 3513-03-9 | 25mg | $216 | 2024-03-01 | Buy |
| Sigma-Aldrich | 203351-M | Blasticidin S, Hydrochloride, Streptomyces sp., Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 589205 - Calbiochem sterile; sterile-filtered, suitable for cell culture | 3513-03-9 | 10ml | $583 | 2022-05-15 | Buy |
| Sigma-Aldrich | 203351-M | Blasticidin S, Hydrochloride, Streptomyces sp., Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 589205 - Calbiochem sterile; sterile-filtered, suitable for cell culture | 3513-03-9 | 203351-10ML | $583 | 2022-05-15 | Buy |
| Sigma-Aldrich | 15205 | Blasticidine S hydrochloride | 3513-03-9 | 25MG | $173 | 2022-05-15 | Buy |
| Sigma-Aldrich | 15205 | Blasticidine S hydrochloride | 3513-03-9 | 100MG | $476 | 2022-05-15 | Buy |
BLASTICIDIN S HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1?Inhibits translation by trapping deformed tRNA on the ribosome.1?The ABC-type transporter NppA1A2BCD is required for uptake of blasticidin S and other peptidyl nucleoside antibiotics in?Pseudomonas aeruginosa?PA14.2?Selection agent for bis, bsr and bsd transformed cells.3,4
Chemical Properties
White powder
Uses
Blasticidin S hydrochloride is a salt of blasticidin S, an amphoteric nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S hydrochloride was originally isolated fby acetone precipitation. For historical reasons only the salt has been routinely available to researchers. Both the salt and free base are freely water soluble. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations.
Uses
Inhibits protein synthesis and induces apoptosis. Used to study protein synthesis at the level of peptide bond formation.
Uses
Blasticidin S hydrochloride is used to inhibit protein synthesis in prokaryotic and eukaryotic organisms. It also induces apoptosis.
General Description
Nucleoside antibiotic that specifically inhibits protein synthesis in both prokaryotes and eukaryotes. Suitable for selection of cells carrying plasmids conferring blasticidin resistance. Blasticidin resistance is conferred by the blasticidin S deaminase gene (bsr) that converts blastisidin S to a nontoxic deaminohydroxy derivative.
storage
Store at -20°C
References
1) Svidritskiy?et al., (2013),?Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome;?Proc. Natl. Acad. Sci. USA?110?12283 2) Pletzer?et al.?(2015),?The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD is Required for Uptake of Peptidyl Nucleoside Antibiotics; J. Bacteriol.?197?2217 3) Asada?et al.?(2015),?Transfection of Babesia bovis by Double Selection with WR99210 and Blasticidin-S and Its Application for Functional Analysis of Thioredoxin Peroxidase-1; PLoS One,?10?e0125993 4) Garg and Qadri (2010),?Hemoglobin transforms anti-inflammatory Salmonella typhi virulence polysaccharide into a TLR-2 agonist; J. Immunol.?184?5980
BLASTICIDIN S HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10319 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22783 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15352 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |