Zuranolone
- CAS No.
- 1632051-40-1
- Chemical Name:
- Zuranolone
- Synonyms
- Zuranolone;SAGE-217;217;1-[2-[(3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyrazole-4-carbonitrile;lygtf;CS-2797;Zuranolone, SAGE-217;Zuranolone, 10 mM in DMSO;Zuranolone SAGE-217 CS-2797;SAGE-217; SAGE 217; SAGE217;1632051-40-1
- CBNumber:
- CB84033495
- Molecular Formula:
- C25H35N3O2
- Molecular Weight:
- 409.57
- MDL Number:
- MFCD31619241
- MOL File:
- 1632051-40-1.mol
| Boiling point | 574.3±30.0 °C(Predicted) |
|---|---|
| Density | 1.32±0.1 g/cm3(Predicted) |
| solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml; DMSO: 10 mg/ml |
| form | A crystalline solid |
| pka | 15.17±0.60(Predicted) |
| InChIKey | HARRKNSQXBRBGZ-BOBURQISNA-N |
| SMILES | C[C@]12CC[C@]3([H])[C@@]4([H])CC[C@](O)(C)C[C@@]4([H])CC[C@@]3([H])[C@]1([H])CC[C@@H]2C(=O)CN1N=CC(C#N)=C1 |&1:1,4,6,10,14,18,20,24,r| |
| FDA UNII | 7ZW49N180B |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H335-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| NFPA 704 |
|
Zuranolone price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0023489 | Zuranolone 99.96% | 1632051-40-1 | 2mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-0023489 | Zuranolone 99.96% | 1632051-40-1 | 5mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-0023489 | Zuranolone 99.96% | 1632051-40-1 | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-0023489 | Zuranolone 99.96% | 1632051-40-1 | 25mg | $320 | 2021-12-16 | Buy |
| ChemScene | CS-0023489 | Zuranolone 99.96% | 1632051-40-1 | 50mg | $545 | 2021-12-16 | Buy |
Zuranolone Chemical Properties,Uses,Production
Description
Zuranolone capsules are used for the treatment postpartum depression (PPD), it is a rapid-acting, once-daily capsule taken for 14 days. Zuranolone works quickly to improve depression symptoms, starting in 3 days compared to current treatment options, which may take weeks or months to work. Zuranolone is the first oral medication to be approved by the FDA to treat postpartum depression.
Uses
Zuranolone is a potent GABAA receptor agonist.
Definition
Zuranolone is a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor-positive modulator, and the first oral medication indicated to treat postpartum depression in adults 2.
Mechanism of action
The mechanism of action of zuranolone in treating PPD is not fully understood but is thought to be related to its positive allosteric modulation of GABAA receptors. Unlike benzodiazepines, another class of GABAA positive modulators, zuranolone binds to the α/β subunit interface presented in all GABAA receptors instead of the α/γ subunit interface. Therefore, zuranolone can bind to both synaptic GABAA receptors, composed of 2α2βγ subunits, and extrasynaptic GABAA receptors, composed of 2α2βδ subunits.
Zuranolone Preparation Products And Raw materials
Raw materials
Preparation Products
Zuranolone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | sales@sjar-tech.com | China | 485 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Lianyungang happen teng technology co., LTD | 15950718863 | wang666xt@163.com | CHINA | 295 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
View Lastest Price from Zuranolone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-21 | Zuranolone
1632051-40-1
|
US $0.00-0.00 / g | 1g | 98 | 1000 | Wuhan Circle Star Chem-medical Technology Co.,Ltd | |
 |
2025-01-13 | Zuranolone
1632051-40-1
|
US $0.00 / g | 1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. |
-
- Zuranolone
1632051-40-1
- US $0.00-0.00 / g
- 98
- Wuhan Circle Star Chem-medical Technology Co.,Ltd
-
- Zuranolone
1632051-40-1
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.