ChemicalBook >> CAS DataBase List >>Zuranolone
Zuranolone
- CAS No.
- 1632051-40-1
- Chemical Name:
- Zuranolone
- Synonyms
- Zuranolone;SAGE-217;217;1-[2-[(3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyrazole-4-carbonitrile;lygtf;CS-2797;Zuranolone, SAGE-217;Zuranolone SAGE-217 CS-2797;SAGE-217; SAGE 217; SAGE217;1632051-40-1;1H-Pyrazole-4-carbonitrile, 1-[(3α,5β)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-
- CBNumber:
- CB84033495
- Molecular Formula:
- C25H35N3O2
- Molecular Weight:
- 409.57
- MDL Number:
- MFCD31619241
- MOL File:
- 1632051-40-1.mol
Last updated:2024-07-31 14:08:44
Boiling point | 574.3±30.0 °C(Predicted) |
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Density | 1.32±0.1 g/cm3(Predicted) |
solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml; DMSO: 10 mg/ml |
form | A crystalline solid |
pka | 15.17±0.60(Predicted) |
InChIKey | HARRKNSQXBRBGZ-BOBURQISNA-N |
SMILES | C[C@]12CC[C@]3([H])[C@@]4([H])CC[C@](O)(C)C[C@@]4([H])CC[C@@]3([H])[C@]1([H])CC[C@@H]2C(=O)CN1N=CC(C#N)=C1 |&1:1,4,6,10,14,18,20,24,r| |
FDA UNII | 7ZW49N180B |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H319-H335-H315 | |||||||||
Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
NFPA 704 |
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Zuranolone price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0023489 | Zuranolone 99.96% | 1632051-40-1 | 2mg | $50 | 2021-12-16 | Buy |
ChemScene | CS-0023489 | Zuranolone 99.96% | 1632051-40-1 | 5mg | $90 | 2021-12-16 | Buy |
ChemScene | CS-0023489 | Zuranolone 99.96% | 1632051-40-1 | 10mg | $150 | 2021-12-16 | Buy |
ChemScene | CS-0023489 | Zuranolone 99.96% | 1632051-40-1 | 25mg | $320 | 2021-12-16 | Buy |
ChemScene | CS-0023489 | Zuranolone 99.96% | 1632051-40-1 | 50mg | $545 | 2021-12-16 | Buy |
Zuranolone Chemical Properties,Uses,Production
Uses
Zuranolone is a potent GABAA receptor agonist.
Definition
Zuranolone is a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor-positive modulator, and the first oral medication indicated to treat postpartum depression in adults 2.
Mechanism of action
The mechanism of action of zuranolone in treating PPD is not fully understood but is thought to be related to its positive allosteric modulation of GABAA receptors. Unlike benzodiazepines, another class of GABAA positive modulators, zuranolone binds to the α/β subunit interface presented in all GABAA receptors instead of the α/γ subunit interface. Therefore, zuranolone can bind to both synaptic GABAA receptors, composed of 2α2βγ subunits, and extrasynaptic GABAA receptors, composed of 2α2βδ subunits.
Zuranolone Preparation Products And Raw materials
Raw materials
Preparation Products
Zuranolone Suppliers
Global( 99)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | sales@sjar-tech.com | China | 177 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9337 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Lianyungang happen teng technology co., LTD | 15950718863 | wang666xt@163.com | CHINA | 295 | 58 |
Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
CR Corporation Lomited | fred.wen@crcorporation.cn | CHINA | 12069 | 58 | |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from Zuranolone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-09-06 | Zuranolone
1632051-40-1
|
US $0.00 / g | 1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. |
-
- Zuranolone
1632051-40-1
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
1632051-40-1(Zuranolone)Related Search:
1H-Pyrazole-4-carbonitrile, 1-[(3α,5β)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-
CS-2797
SAGE-217; SAGE 217; SAGE217;1632051-40-1
lygtf
SAGE-217
217
Zuranolone
1-[2-[(3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyrazole-4-carbonitrile
Inhibitor,inhibit,γ-Aminobutyric acid Receptor,Gamma-aminobutyric acid Receptor,GABA Receptor,Zuranolone
Zuranolone, SAGE-217
1-(2-((3R,5R,8R,9R,10S,13S,14S,17S)-3-Hydroxy-3,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl)-1H-pyrazole-4-carbonitrile
Zuranolone SAGE-217 CS-2797
1632051-40-1