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Zuranolone

Zuranolone Structure
Zuranolone structure
CAS No.
1632051-40-1
Chemical Name:
Zuranolone
Synonyms
Zuranolone;SAGE-217;217;1-[2-[(3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyrazole-4-carbonitrile;lygtf;CS-2797;Zuranolone, SAGE-217;Zuranolone SAGE-217 CS-2797;SAGE-217; SAGE 217; SAGE217;1632051-40-1;1H-Pyrazole-4-carbonitrile, 1-[(3α,5β)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-
CBNumber:
CB84033495
Molecular Formula:
C25H35N3O2
Molecular Weight:
409.57
MDL Number:
MFCD31619241
MOL File:
1632051-40-1.mol
Last updated:2024-07-31 14:08:44
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Zuranolone Properties

Boiling point 574.3±30.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
solubility DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml; DMSO: 10 mg/ml
form A crystalline solid
pka 15.17±0.60(Predicted)
InChIKey HARRKNSQXBRBGZ-BOBURQISNA-N
SMILES C[C@]12CC[C@]3([H])[C@@]4([H])CC[C@](O)(C)C[C@@]4([H])CC[C@@]3([H])[C@]1([H])CC[C@@H]2C(=O)CN1N=CC(C#N)=C1 |&1:1,4,6,10,14,18,20,24,r|
FDA UNII 7ZW49N180B

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H335-H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
NFPA 704
0
2 0

Zuranolone price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0023489 Zuranolone 99.96% 1632051-40-1 2mg $50 2021-12-16 Buy
ChemScene CS-0023489 Zuranolone 99.96% 1632051-40-1 5mg $90 2021-12-16 Buy
ChemScene CS-0023489 Zuranolone 99.96% 1632051-40-1 10mg $150 2021-12-16 Buy
ChemScene CS-0023489 Zuranolone 99.96% 1632051-40-1 25mg $320 2021-12-16 Buy
ChemScene CS-0023489 Zuranolone 99.96% 1632051-40-1 50mg $545 2021-12-16 Buy
Product number Packaging Price Buy
CS-0023489 2mg $50 Buy
CS-0023489 5mg $90 Buy
CS-0023489 10mg $150 Buy
CS-0023489 25mg $320 Buy
CS-0023489 50mg $545 Buy

Zuranolone Chemical Properties,Uses,Production

Uses

Zuranolone is a potent GABAA receptor agonist.

Definition

Zuranolone is a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor-positive modulator, and the first oral medication indicated to treat postpartum depression in adults 2.

Mechanism of action

The mechanism of action of zuranolone in treating PPD is not fully understood but is thought to be related to its positive allosteric modulation of GABAA receptors. Unlike benzodiazepines, another class of GABAA positive modulators, zuranolone binds to the α/β subunit interface presented in all GABAA receptors instead of the α/γ subunit interface. Therefore, zuranolone can bind to both synaptic GABAA receptors, composed of 2α2βγ subunits, and extrasynaptic GABAA receptors, composed of 2α2βδ subunits.

Zuranolone Preparation Products And Raw materials

Raw materials

Preparation Products

Zuranolone Suppliers

Global( 99)Suppliers
Supplier Tel Email Country ProdList Advantage
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 +86-18600796368 sales@sjar-tech.com China 177 58
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9337 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32836 60
Lianyungang happen teng technology co., LTD 		15950718863 wang666xt@163.com CHINA 295 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795 info@shochem.com CHINA 288 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244 mike_yan@xuanranglobal.com CHINA 4022 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10522 58
CR Corporation Lomited 		fred.wen@crcorporation.cn CHINA 12069 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Supplier Advantage
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		58
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Lianyungang happen teng technology co., LTD 		58
Shochem(Shanghai) Co.,Ltd 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
CR Corporation Lomited 		58
InvivoChem 		58

View Lastest Price from Zuranolone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Zuranolone pictures 2024-09-06 Zuranolone
1632051-40-1
 US $0.00 / g 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
  • Zuranolone pictures
  • Zuranolone
    1632051-40-1
  • US $0.00 / g
  • More Than 99%
  • BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

1632051-40-1(Zuranolone)Related Search:

PA 824
1H-Pyrazole-4-carbonitrile, 1-[(3α,5β)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]- CS-2797 SAGE-217; SAGE 217; SAGE217;1632051-40-1 lygtf SAGE-217 217 Zuranolone 1-[2-[(3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyrazole-4-carbonitrile Inhibitor,inhibit,γ-Aminobutyric acid Receptor,Gamma-aminobutyric acid Receptor,GABA Receptor,Zuranolone Zuranolone, SAGE-217 1-(2-((3R,5R,8R,9R,10S,13S,14S,17S)-3-Hydroxy-3,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl)-1H-pyrazole-4-carbonitrile Zuranolone SAGE-217 CS-2797 1632051-40-1