ChemicalBook >> CAS DataBase List >>TETRAETHYL METHYLENEDIPHOSPHONATE
TETRAETHYL METHYLENEDIPHOSPHONATE
- CAS No.
- 1660-94-2
- Chemical Name:
- TETRAETHYL METHYLENEDIPHOSPHONATE
- Synonyms
- 1-[diethoxyphosphorylmethyl(ethoxy)phosphoryl]oxyethane;1-5kg;NSC 133889;AURORA KA-1506;enediphosphonate;Tenofovir Impurity 183;BIS(DIETHOXYPHOSPHINYL)METHANE;tetraethyl methylenediphosphate;methylenebis(diethylphosphonate);TETRAETHYL METHYLENEDIPHOSPHONATE
- CBNumber:
- CB8435905
- Molecular Formula:
- C9H22O6P2
- Molecular Weight:
- 288.21
- MDL Number:
- MFCD00039887
- MOL File:
- 1660-94-2.mol
- MSDS File:
- SDS
Last updated:2025-01-27 09:38:02
| Boiling point | 171-174 °C11 mm Hg(lit.) |
|---|---|
| Density | 1.16 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | Liquid |
| Specific Gravity | 1.160 |
| color | Clear yellow to yellow-brown |
| Water Solubility | Slightly miscible with water. |
| BRN | 1813241 |
| InChIKey | STJWVOQLJPNAQL-UHFFFAOYSA-N |
| CAS DataBase Reference | 1660-94-2(CAS DataBase Reference) |
| FDA UNII | WT3D5Q9EPC |
| EPA Substance Registry System | Phosphonic acid, methylenebis-, tetraethyl ester (1660-94-2) |
| UNSPSC Code | 12352108 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P280g-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SZ9150000 | |||||||||
| Hazard Note | Corrosive | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29319090 | |||||||||
| Toxicity | mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03139, | |||||||||
| NFPA 704 |
|
TETRAETHYL METHYLENEDIPHOSPHONATE price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 359181 | Tetraethyl methylenediphosphonate 97% | 1660-94-2 | 5ml | $113 | 2024-03-01 | Buy |
| Sigma-Aldrich | 359181 | Tetraethyl methylenediphosphonate 97% | 1660-94-2 | 25ml | $476 | 2024-03-01 | Buy |
| Alfa Aesar | A14532 | Tetraethyl methylenediphosphonate, 98+% | 1660-94-2 | 5g | $83.4 | 2024-03-01 | Buy |
| Alfa Aesar | A14532 | Tetraethyl methylenediphosphonate, 98+% | 1660-94-2 | 25g | $303 | 2024-03-01 | Buy |
| Alfa Aesar | A14532 | Tetraethyl methylenediphosphonate, 98+% | 1660-94-2 | 100g | $911.65 | 2024-03-01 | Buy |
TETRAETHYL METHYLENEDIPHOSPHONATE Chemical Properties,Uses,Production
Chemical Properties
clear yellow to yellow-brown liquid
Uses
Reactant for synthesis of:
- Dual substrate-site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
- Unnatural alpha-amino acid derivatives containing gem-biphosphonates
- Biphenyl sulfonylamino Me bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption
- Lycopene via Wittig-Horner reaction
- Alkylaminoethylbisphosphinic acids to target farnesyl diphosphate synthase
- Aromatic bisphosphonates for use as inhibitors of geranylgeranyl diphosphate synthase
Precursor for synthesis of dendritic polyglycerol anions used toward L-selectin inhibition
Uses
Tetraethyl methylidenebisphosphonate, can be used in the synthesis of tetrazoloquinoline-based mono- and bisphosphonate esters as potent anti-inflammatory agents. It is also an intermediate for the synthesis of new bisphosphonate and bisphosphonic acid derivatives with anticancer and antischistosomal activity.
Synthesis Reference(s)
Synthetic Communications, 20, p. 1865, 1990 DOI: 10.1080/00397919008053112
Tetrahedron Letters, 34, p. 1515, 1993 DOI: 10.1016/S0040-4039(00)60333-7
reaction suitability
reaction type: C-C Bond Formation
TETRAETHYL METHYLENEDIPHOSPHONATE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 206)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86-13288715578 +86-13288715578 | sales@hbmojin.com | China | 12765 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 20323 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15235 | 58 |
| Alfa Chemistry | info@alfa-chemistry.com | United States | 2344 | 58 |
View Lastest Price from TETRAETHYL METHYLENEDIPHOSPHONATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-16 | Tetraethyl methylenediphosphonate
1660-94-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2019-12-20 | TETRAETHYL METHYLENEDIPHOSPHONATE
1660-94-2
|
US $1.00 / KG | 1KG | 99% | 1000kgs | Career Henan Chemical Co |
-
- Tetraethyl methylenediphosphonate
1660-94-2
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- TETRAETHYL METHYLENEDIPHOSPHONATE
1660-94-2
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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TETRAETHYL METHYLENEDIPHOSPHONATE
Tetraethyl methylenediphosphonate, 98+%
methanediyl-bis-phosphonic acid tetraethyl ester
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Tetraethyl methylenediphosphonate,97%
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Tetraethyl Methylenediphosphonate, 97% 5ML
tetraethyl methylenediphosphate
Bis(diethoxyphosphinyl)methane, Methylenediphosphonic acid tetraethylester
[α,β-Methylene]diphosphoric acid tetraethyl
Methylenebis(phosphonic acid diethyl)
Methylenebisphosphonic acid tetraethyl
Methylenedi(phosphonic acid diethyl) ester
NSC 133889
methylenebis(diethylphosphonate)
methylenebis-phosphonicacitetraethylester
Tetraethyl methylenediphosphonate 97%
Tetraethylemethylenediphosphonate
Tetraethyl methylidenediphosphonate
1-5kg
enediphosphonate
Phosphonic acid, P,P'-methylenebis-, P,P,P',P'-tetraethyl ester
Tenofovir Impurity 183
diethyl [(diethoxyphosphoryl)methyl]phosphonate
1-[diethoxyphosphorylmethyl(ethoxy)phosphoryl]oxyethane
1660-94-2
CH2POOCH2CH322
C9H22O6P2
Horner-Wadsworth-Emmons Reagents
Synthetic Reagents
Olefination
C-C Bond Formation
Naphthyridine,Quinoline
Other
OLED