KN-62
- CAS No.
- 127191-97-3
- Chemical Name:
- KN-62
- Synonyms
- KN-2;N 62;KN-62;CS-756;KN-62 97%;KN-62,97%;KN 62;KN-2;KN-62, 99+%;KN 62; KN62;KN-62, >=98%
- CBNumber:
- CB8443368
- Molecular Formula:
- C38H35N5O6S2
- Molecular Weight:
- 721.84
- MDL Number:
- MFCD00083180
- MOL File:
- 127191-97-3.mol
- MSDS File:
- SDS
Melting point | 92-94°C |
---|---|
Boiling point | 964.7±75.0 °C(Predicted) |
Density | 1.388 |
storage temp. | -20°C |
solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL |
form | solid |
pka | 4.07±0.13(Predicted) |
color | white |
CAS DataBase Reference | 127191-97-3(CAS DataBase Reference) |
FDA UNII | 63HM46XPOW |
SAFETY
Risk and Safety Statements
Safety Statements | 24/25 |
---|---|
WGK Germany | 3 |
HS Code | 29339980 |
KN-62 price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | I2142 | KN-62 ≥95%, powder | 127191-97-3 | .5mg | $132 | 2024-03-01 | Buy |
Sigma-Aldrich | 422706 | KN-62 | 127191-97-3 | 1mg | $181 | 2023-01-07 | Buy |
Alfa Aesar | J62444 | KN-62 | 127191-97-3 | 1mg | $103.65 | 2024-03-01 | Buy |
Alfa Aesar | J62444 | KN-62 | 127191-97-3 | 10mg | $604.65 | 2024-03-01 | Buy |
Cayman Chemical | 13318 | KN-62 ≥98% | 127191-97-3 | 1mg | $49 | 2024-03-01 | Buy |
KN-62 Chemical Properties,Uses,Production
Chemical Properties
Yellow Solid
Uses
selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II,
Uses
A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II
Uses
It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).
Definition
ChEBI: 5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester is a member of piperazines.
General Description
A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.
Biological Activity
Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .
Biochem/physiol Actions
Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II.
storage
-20°C (desiccate)
KN-62 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9236 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32835 | 60 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49403 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29820 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13484 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23430 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
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