MYCMI-6
- CAS No.
- 681282-09-7
- Chemical Name:
- MYCMI-6
- Synonyms
- MYCMI-6;NSC354961;MYCMI-6(NSC 354961);3-((9-Amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine;2,6-Pyridinediamine, 3-[2-(9-amino-7-ethoxy-3-acridinyl)diazenyl]-;NSC 354961,cells,neuroblastoma,cytotoxic,mice,tumor,inhibit,nude,lymphoma,MYCMI-6,athymic,Inhibitor,NSC-354961,MYC-driven,Apoptosis,Myc,c-Myc,MYCMI6,MCF7,MYCMI 6
- CBNumber:
- CB84668251
- Molecular Formula:
- C20H19N7O
- Molecular Weight:
- 373.41
- MDL Number:
- MFCD32701920
- MOL File:
- 681282-09-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
MYCMI-6 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Ambeed | A1329217 | 3-((9-Amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine 98% | 681282-09-7 | 1mg | $250 | 2021-12-16 | Buy |
| Ambeed | A1329217 | 3-((9-Amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine 98% | 681282-09-7 | 5mg | $420 | 2021-12-16 | Buy |
| Ambeed | A1329217 | 3-((9-Amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine 98% | 681282-09-7 | 10mg | $720 | 2021-12-16 | Buy |
| DC Chemicals | DC10952 | MYCMI-6(NSC354961) >98% | 681282-09-7 | 250mg | $950 | 2021-12-16 | Buy |
MYCMI-6 Chemical Properties,Uses,Production
Uses
MYCMI-6 (NSC354961) is a potent and selective endogenous MYC:MAX protein interactions inhibitor. MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a Kd of 1.6?μM. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner (IC50<0.5?μM). MYCMI-6 is not cytotoxic to normal human cells. MYCMI-6 induces apoptosis[1].
in vivo
MYCMI-6 (20 mg/kg; i.p.; daily for 1-2 weeks) induces massive apoptosis and reduces tumor cell proliferation, tumor microvasculature density and MYC:MAX interaction in a MYC-dependent xenograft tumor model[1].
| Animal Model: | 6-8 weeks old athymic nude mice (bearing MYCN-amplified SK-N-DZ neuroblastoma cells)[1] |
| Dosage: | 20?mg/kg body weight |
| Administration: | I.p.; daily for 1-2 weeks |
| Result: | A dramatic increase in the extension of apoptotic areas in the tumors and a significant increase in non-proliferative areas as determined by Ki67 staining in tumors. |
References
[1] Castell A, et al. A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation. Sci Rep. 2018 Jul 3;8(1):10064. DOI:10.1038/s41598-018-28107-4
MYCMI-6 Preparation Products And Raw materials
Raw materials
Preparation Products
MYCMI-6 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9330 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| Henan Weituxi Chemical Technology Co., Ltd. | 0371-63284658 18135795563 | 2885349392@qq.com | China | 9980 | 58 |
| Hahui (Shanghai) Pharmaceutical Technology Co., Ltd. | 021-13472633-721 13472633721 | 454407203@qq.com | China | 583 | 58 |
