SP 4206
- CAS No.
- 515846-21-6
- Chemical Name:
- SP 4206
- Synonyms
- SP 4206;SP-4206,SP4206;2-Furancarboxylic acid, 5-[[4-[5-[1-[N-(aminoiminomethyl)-D-leucylglycyl]-4-piperidinyl]-1-methyl-1H-pyrazol-3-yl]-2,3-dichlorophenoxy]methyl]-
- CBNumber:
- CB84668529
- Molecular Formula:
- C30H37Cl2N7O6
- Molecular Weight:
- 662.56
- MDL Number:
- MFCD34469270
- MOL File:
- 515846-21-6.mol
SP 4206 Chemical Properties,Uses,Production
Definition
ChEBI: N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamide is a leucine derivative obtained by fpormal condensation of the secondary amino group of 5-({2,3-dichloro-4-[1-methyl-5-(piperidin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)-2-furoic acid and the carboxy group of N-amidino-L-leucylglycine It is a member of guanidines, a furoic acid, a pyrazolylpiperidine, a glycine derivative, a dichlorobenzene and a D-leucine derivative.
Biological Activity
SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity (Kd=70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα (Kd=10 nM)[1]. SP4206 binds the WT IL-2, IL-2 variant K35L/M39V, IL-2 variant P65A, and IL-2 variant V69A with EC50s of 68.8, 80.1, 117.0, and 10.4 nM, respectively[1].
References
[1]. Thanos CD, et al. Hot-spot mimicry of a cytokine receptor by a small molecule. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15422-7.
SP 4206 Preparation Products And Raw materials
Raw materials
Preparation Products
SP 4206 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |
cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 9946 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9180 | 58 |
Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |