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CP-105,696

CP-105,696 structure

CAS No.: 158081-99-3

Chemical Name:: CP-105,696

Synonyms: CP-105,696;Pfizer 105696;UNII-Z7354TW4BM;CP105696,CP 105696;CP-105,696 >=98% (HPLC);CP105696 (Pfizer 105696);CP 105696; CP105696; CP-105696; UNII-Z7354TW4BM; PFIZER 105696;1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentanecarboxylic acid;1-((3S,4R)-3-([1,1'-Biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentanecarboxylic acid;1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentane-1-carboxylic acid

CBNumber:: CB84741785

Molecular Formula:: C28H28O4

Molecular Weight:: 428.52

MDL Number:: MFCD00934881

MOL File:: 158081-99-3.mol

Last updated:2023-05-18 11:31:12

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CP-105,696 Properties

Boiling point	651.2±55.0 °C(Predicted)
Density	1.252±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	Soluble in DMSO
pka	4.35±0.20(Predicted)
form	powder
color	white to beige
FDA UNII	Z7354TW4BM

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312+P330-P501

CP-105,696 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PZ0363	CP-105,696 ≥98% (HPLC)	158081-99-3	5MG	$164	2023-06-20	Buy
Sigma-Aldrich	PZ0363	CP-105,696 ≥98% (HPLC)	158081-99-3	25MG	$508	2023-06-20	Buy
ChemScene	CS-0014935	CP-105696 ≥98.0%	158081-99-3	5mg	$290	2021-12-16	Buy
Biorbyt Ltd	orb573184	CP 105696 >98%	158081-99-3	100mg	$1431.4	2021-12-16	Buy
Biorbyt Ltd	orb573184	CP 105696 >98%	158081-99-3	250mg	$2541.5	2021-12-16	Buy

Product number	Packaging	Price	Buy
PZ0363	5MG	$164	Buy
PZ0363	25MG	$508	Buy
CS-0014935	5mg	$290	Buy
orb573184	100mg	$1431.4	Buy
orb573184	250mg	$2541.5	Buy

CP-105,696 Chemical Properties,Uses,Production

Uses

CP-105,696 has been used as a leukotriene B4 receptor (LTB4R) antagonist to study the influence of the LTB4 pathway in the pathogenesis of acute itch flares in irritant calcipotriol (MC903)+ model allergen ovalbumin (OVA) sensitized murine model of atopic dermatitis (AD)-like disease.

Biochem/physiol Actions

CP-105,696 is an orally active, potent and selective leukotriene B4 receptor (LTB4R) antagonist (IC50 against [3H]LTB4 = 5.6 nM for binding human neutrophils; IC50 = 9.7 nM & 30.3 nM, respectively using guinea pig spleen or mouse membranes) that targets LTB4R high- and low-affinity binding sites in a LTB4 non-competitive and competitive manner, respectively. CP-105,696 inhibits 5 nM LTB4-induced human neutrophils chemotaxis and CDllb upregualtion (IC50 = 5.2 nM and 430 nM, respectively) without inhibiting cyclooxygenase activity or affecting chemotaxis induced by C5a, PAF, IL-8. Oral administration is efficacious against intradermal LTB4 (100 ng/mouse), but not IL-1, injection-induced neutrophil accumulation in mice and guinea pigs (ED50 = 4.2 and 0.26 mgkg, respectively). CP-105,696 in vivo efficacy is also demonstrated in other animal models, including collagen-induced arthritis (CIA; 0.3-10 mg/kg in mice), allergic encephalomyelitis (ED50= 8.6 mg/kg; mice), and asthma (10-30 mg/kg; primate).

CP-105,696 Preparation Products And Raw materials

Raw materials

Preparation Products

CP-105,696 Suppliers

Global( 34)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Chemia Biotechnology（Shanghai） Co., Ltd	+8613816753574	info@chemia-pharm.com	CHINA	311	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai fuxiang biotechnology co., ltd	13611719524	2674347328@qq.com	China	49	58
Nanjing Chemlin Chemical Co., Ltd	025-83697070	info@chemlin.com.cn	China	18361	64
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4309	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8014	62
Chemleader Biomedical Co., Limited.	021-58180488	sales@MedChemLeader.com	China	1005	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Chemia Biotechnology（Shanghai） Co., Ltd	58
InvivoChem	58
LEAPCHEM CO., LTD.	58
Shanghai fuxiang biotechnology co., ltd	58
Nanjing Chemlin Chemical Co., Ltd	64
Sigma-Aldrich	80
Shanghai Lollane Biological Technology Co.,Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Chemleader Biomedical Co., Limited.	58

CP-105,696 1-[(3S,4R)-4-hydroxy-3-[(4-phenylphenyl)methyl]-3,4-dihydro-2H-chromen-7-yl]cyclopentane-1-carboxylic acid 1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentane-1-carboxylic acid CP 105696; CP105696; CP-105696; UNII-Z7354TW4BM; PFIZER 105696 Pfizer 105696 UNII-Z7354TW4BM Cyclopentanecarboxylic acid, 1-[(3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-3,4-dihydro-4-hydroxy-2H-1-benzopyran-7-yl]- CP-105,696 >=98% (HPLC) CP105696 (Pfizer 105696) CP105696,CP 105696 1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentanecarboxylic acid 1-((3S,4R)-3-([1,1'-Biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentanecarboxylic acid 1-((3S,4R)-3-([1,1'-Biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentane-1-carboxylic acid 1-[(3S,4R)-3-({[1,1'-biphenyl]-4-yl}methyl)-4-hydroxy-3,4-dihydro-2H-1-benzopyran-7-yl]cyclopentane-1-carboxylic acid 158081-99-3 API