D-Alanyl-D-alanine
- CAS No.
- 923-16-0
- Chemical Name:
- D-Alanyl-D-alanine
- Synonyms
- D-ALA-D-ALA;D-Ala-D-Ala-OH;H-D-ALA-D-ALA-OH;D-ALANYL-D-ALANINE;D-Alanine, D-alanyl-;N-(D-Alanyl)-D-alanine;D-Ala-D-Ala-OH≥ 95% (HPLC);D-Alanyl-D-alanine USP/EP/BP;
D -Ala-D -Ala;(R)-N-(D-Alanyl)-2-methylglycine
- CBNumber:
- CB8478463
- Molecular Formula:
- C6H12N2O3
- Molecular Weight:
- 160.17
- MDL Number:
- MFCD00066038
- MOL File:
- 923-16-0.mol
| Melting point | 120 °C |
|---|---|
| Boiling point | 402.6±30.0 °C(Predicted) |
| Density | 1.208±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| form | Solid |
| pka | 3.16±0.10(Predicted) |
| color | White to off-white |
| CAS DataBase Reference | 923-16-0(CAS DataBase Reference) |
| FDA UNII | 1BVK9QMW8G |
| UNSPSC Code | 12352202 |
| NACRES | NA.26 |
D-Alanyl-D-alanine price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A0912 | D-Ala-D-Ala | 923-16-0 | 250mg | $218 | 2024-03-01 | Buy |
| Sigma-Aldrich | A0912 | D-Ala-D-Ala | 923-16-0 | 1g | $619 | 2024-03-01 | Buy |
| Usbiological | 260692 | D-Ala-D-Ala-OH | 923-16-0 | 250mg | $410 | 2021-12-16 | Buy |
| TRC | A576225 | D-Alanyl-D-Alanine | 923-16-0 | 100mg | $65 | 2021-12-16 | Buy |
| Chem-Impex | 05924 | D-Ala-D-Ala-OH,99%(HPLC) 99%(HPLC) | 923-16-0 | 250MG | $72.8 | 2021-12-16 | Buy |
D-Alanyl-D-alanine Chemical Properties,Uses,Production
Chemical Properties
White to off-white powder
Uses
D-Ala-D-Ala is a bacterial endogenous metabolite. D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase[1][2][3].
Definition
ChEBI: D-alanyl-D-alanine is a dipeptide comprising D-alanine with a D-alanyl residue attached to the alpha-nitrogen. It is a component of bacterial peptidoglycan and forms an important target for development of antibacterial drugs. It has a role as an Escherichia coli metabolite. It is a tautomer of a D-alanyl-D-alanine zwitterion.
Biological Activity
D-Ala-D-Ala is found in the stem termini of peptidoglycan side-chain pentapeptide found in the cell walls of gram positive bacteria. The D-ala-d-ala stem termini is the site of interaction of glycopeptide antibiotics such as vancomycin and teicoplanin. D-ala-D-ala is a substrate used to study kinetics of UDPMurNAc-tripeptide D-alanyl-D-alanine-adding (ligase) enzyme.', 'D-Ala-D-Ala, a terminus moiety of bacterial peptidoglycans, is used for affinity chromatography and binding mechanism studies of antibiotics such as teicoplanin, ristocetin, vancomycin.
IC 50
Microbial Metabolite
References
[1] Kitamura Y, et al. Structure of D-alanine-D-alanine ligase from Thermus thermophilus HB8: cumulative conformational change and enzyme-ligand interactions. Acta Crystallogr D Biol Crystallogr. 2009 Oct;65(Pt 10):1098-106. DOI:10.1107/S0907444909029710
[2] Tytgat I, et al. DD-ligases as a potential target for antibiotics: past, present and future. Curr Med Chem. 2009;16(20):2566-80. DOI:10.2174/092986709788682029
[3] Trivedi RR, et al. Mechanical Genomic Studies Reveal the Role of d-Alanine Metabolism in Pseudomonas aeruginosa Cell Stiffness. mBio. 2018 Sep 11;9(5):e01340-18. DOI:10.1128/mBio.01340-18
D-Alanyl-D-alanine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +86-028-64841719 +8617390183901 | daisy@enlaibio.com | China | 1106 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29859 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22854 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 | sales1@gotopbio.com | CHINA | 2609 | 58 |
View Lastest Price from D-Alanyl-D-alanine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-24 | D-Ala-D-Ala
923-16-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | |
 |
2025-04-04 | D-Alanyl-D-alanine
923-16-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
|
 |
2019-09-02 | D-Alanyl-D-alanine
923-16-0
|
US $7.00 / KG | 1KG | 99% | JD 389 | Career Henan Chemical Co |
-
- D-Ala-D-Ala
923-16-0
- US $0.00-0.00 / kg
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- D-Alanyl-D-alanine
923-16-0
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- D-Alanyl-D-alanine
923-16-0
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
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