eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem
- CAS No.
- 304475-63-6
- Chemical Name:
- eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem
- Synonyms
- eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem;InSolution eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem;2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-
- CBNumber:
- CB84813855
- Molecular Formula:
- C21H17Cl3N4OS
- Molecular Weight:
- 479.81
- MDL Number:
- MOL File:
- 304475-63-6.mol
Last updated:2023-05-09 09:30:53
Density | 1.474±0.06 g/cm3(Predicted) |
---|---|
pka | 10.70±0.70(Predicted) |
FDA UNII | J8PSF5Z8KJ |
eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem price More Price(2)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 324897 | InSolution eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem | 304475-63-6 | 5mg | $259 | 2024-03-01 | Buy |
Sigma-Aldrich | 324895 | eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem | 304475-63-6 | 5mg | $230 | 2024-03-01 | Buy |
eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Chemical Properties,Uses,Production
General Description
A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 μM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 ~3 μM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. The solid form of this compound (Cat. No. 324895) is also available.
Biochem/physiol Actions
Cell permeable: yes
eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Suppliers
Global( 2)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |
eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem
InSolution eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem
2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-
304475-63-6