C18 Phytoceramide-d3 (t18:0/18:0-d3)
- CAS No.
- 1354806-91-9
- Chemical Name:
- C18 Phytoceramide-d3 (t18:0/18:0-d3)
- Synonyms
- C18 Phytoceramide-d3 (t18:0/18:0-d3);N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-octadecanamide-18,18,18-d3
- CBNumber:
- CB84814382
- Molecular Formula:
- C36H73NO4
- Molecular Weight:
- 583.98
- MDL Number:
- MOL File:
- 1354806-91-9.mol
C18 Phytoceramide-d3 (t18:0/18:0-d3) price More Price(2)
C18 Phytoceramide-d3 (t18:0/18:0-d3) Chemical Properties,Uses,Production
Description
C18 Phytoceramide-d3 (t18:0/18:0-d3) is intended for use as an internal standard for the quantification of C18 phytoceramide (t18:0/18:0) by GC- or LC-MS. C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in S. cerevisiae, wheat grains, and the stratum corneum layer of mammalian epidermis. Cer(t18:0/18:0) is composed of a phytosphingosine backbone amine-linked to a C18 fatty acid chain. Cer(t18:0/18:0) has a role in regulation of apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain. It also inhibits expression of the allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated murine skin tissue. Formulations containing cer(t18:0/18:0) have been used used in cosmetics as a skin protectants as they reduce water loss to prevent epidermal dehydration and irritation. [Matreya, LLC. Catalog No. 2210]
Uses
Ceramide 3-d3 (N-Stearoyl phytosphingosine-d3) is deuterium labeled Ceramide 3. C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation[1].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
C18 Phytoceramide-d3 (t18:0/18:0-d3) Preparation Products And Raw materials
Raw materials
Preparation Products
C18 Phytoceramide-d3 (t18:0/18:0-d3) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Cayman Chemical Company | 800-3649897 | Caymanname@qq.com | China | 21645 | 58 |