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Nerolidol

CAS No.
40716-66-3
Chemical Name:
Nerolidol
Synonyms
1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (E)-;E-Nerolidol;(E)-Nerolidol;(6E)-3,7,11-Trimethyldodeca-1,6,10-trien-3-ol;trans-Nerolidal solution;Nerolidol;trans-Form;Nerolidol (E);Einecs 255-053-4;Trans-(E)-Nerolidol
CBNumber:
CB8497598
Molecular Formula:
C15H26O
Molecular Weight:
222.37
MDL Number:
MFCD00008911
MOL File:
40716-66-3.mol
Last updated:2024-11-19 23:02:33

Nerolidol Properties

Boiling point 145-146 °C12 mm Hg(lit.)
Density 0.876 g/mL at 25 °C(lit.)
refractive index n20/D 1.479(lit.)
Flash point 230 °F
storage temp. -20°C
solubility DMF: miscible,DMSO: miscible,Ethanol: miscible,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form Liquid
pka 14.40±0.29(Predicted)
color Colorless to light yellow
Odor at 100.00 %. floral green citrus woody waxy
Odor Type floral
JECFA Number 1646
Merck 13,6501
BRN 5731231
Stability Light Sensitive
LogP 5.316 (est)
EWG's Food Scores 1
FDA UNII FG5V0N8P2H
NIST Chemistry Reference 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (e)-(40716-66-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H317-H319-H410
Precautionary statements  P261-P264-P273-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
10-23
Toxicity Both the acute oral LD50 in rats and the acute dermal LD50 in rabbits exceeded 5 g/kg (Russell. 1973).
NFPA 704
0
2 0

Nerolidol price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 18143 trans-Nerolidol analyticalstandard 40716-66-3 100mg $81.5 2024-03-01 Buy
Sigma-Aldrich 04610590 trans-Nerolidol primary pharmaceutical reference standard 40716-66-3 50mg $158.8 2024-03-01 Buy
Sigma-Aldrich CRM40742 trans-Nerolidal solution certified reference material, 2000?μg/mL in methanol, ampule of 1?mL 40716-66-3 1mL $95.2 2022-05-15 Buy
Cayman Chemical 25778 trans-Nerolidol 40716-66-3 50mg $27 2024-03-01 Buy
Cayman Chemical 25778 trans-Nerolidol 40716-66-3 100mg $48 2024-03-01 Buy
Product number Packaging Price Buy
18143 100mg $81.5 Buy
04610590 50mg $158.8 Buy
CRM40742 1mL $95.2 Buy
25778 50mg $27 Buy
25778 100mg $48 Buy

Nerolidol Chemical Properties,Uses,Production

Description

trans-Nerolidol is a sesquiterpene that has been found in various plants, including C. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties. In a disc assay, trans-nerolidol inhibits the growth of S. aureus, B. subtilis, E. coli, and S. cerevisiae with zones of inhibition measuring 10, 9, 10, and 4 mm, respectively. It reduces viability of CaCo-2 adenocarcinoma cells with an IC50 value of 28.7 mg/L and reduces production of reactive oxygen species (ROS). trans-Nerolidol is insecticidal against A. aegypti larvae with a 24-hour LC50 value of 9 mg/L.

Occurrence

Reported to be found in cabreuva oil, oil of neroli, balsam Peru, ylang ylang and many others (Gildemeister & Hoffman, 1959).

Uses

Nerolidol (cas# 40716-66-3) is a terpene standard found in cannabis.

Preparation

By isolation from a suitable essential oil or by chemical synthesis.

Definition

ChEBI: Nerolidol is a farnesane sesquiterpenoid that is dodeca-1,6,10-triene which carries methyl groups at positions 3, 7 and 11 and a hydroxy group at position 3. It is a natural product that is present in various flowers and plants with a floral odor. Chemically, it exists in two geometric isomers, trans and cis forms. It is widely used in cosmetics (e.g. shampoos and perfumes), in non-cosmetic products (e.g. detergents and cleansers) and also as a food flavoring agent. It has a role as a flavouring agent, a cosmetic, a pheromone, a neuroprotective agent, an antifungal agent, an anti-inflammatory agent, an antihypertensive agent, an antioxidant, a volatile oil component, an insect attractant and a herbicide. It is a farnesane sesquiterpenoid, a tertiary allylic alcohol and a volatile organic compound.

3796-70-1
1826-67-1
40716-66-3
Synthesis of Nerolidol from Geranylacetone and Vinylmagnesium bromide
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View Lastest Price from Nerolidol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
trans-Nerolidol pictures 2024-11-19 trans-Nerolidol
40716-66-3
US $92.00-40.00 / mg ≥98% 10g TargetMol Chemicals Inc.
Nerolidol pictures 2019-07-06 Nerolidol
40716-66-3
US $1.00 / kg 1g 99% 100KG Career Henan Chemical Co
  • trans-Nerolidol pictures
  • trans-Nerolidol
    40716-66-3
  • US $92.00-40.00 / mg
  • ≥98%
  • TargetMol Chemicals Inc.
  • Nerolidol pictures
  • Nerolidol
    40716-66-3
  • US $1.00 / kg
  • 99%
  • Career Henan Chemical Co
(6E)-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol Trans-(E)-Nerolidol 3-Hydroxy-3,7,11-trimethyl-1,6,10-dodecatriene Nerolidol (E)-3,7,11-trimethyldodeca-1,6,10-trien-3-ol nerolidol,(6E)-3,7,11-trimethyl-1,6,10-dodecatrien-3-ol,peruviol,trans-nerolidol 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (6E)- TRANS-NEROLIDOL WITH GC (E)-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol, trans-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol (E)-3,7,11-Trimethyldodeca-1,6,10-triene-3-ol [R,Z,(-)]-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol Einecs 255-053-4 Nerolidol (E) Nerolidol trans-form trans-Nerolidol,(E)-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol, trans-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol trans-Form Teprenone Impurity 19 Teprenone Impurity 19 (trans-Nerolidol) 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (E)- (6E)-3,7,11-Trimethyldodeca-1,6,10-trien-3-ol (E)-Nerolidol E-Nerolidol trans-Nerolidal solution Teprenone Impurity 5 (trans-Nerolidol) Teprenone Impurity 2 (trans-Nerolidol) 40716-66-3