3-O-Ethyl-L-ascorbic acid
- CAS No.
- 86404-04-8
- Chemical Name:
- 3-O-Ethyl-L-ascorbic acid
- Synonyms
- ETHYL ASCORBIC ACID;VCE;vitaMin C ethyl ether;VC ethyl ether;3-O-Ethyl Ascorbyl Ether;3-0-Ethyl Ascorbic acid;Ethyl ascorbyl ether;(R)-5-((S)-1,2-dihydroxyethyl)-4-ethoxy-3-hydroxyfuran-2(5H)-one;(5r)-5-[(1s)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxy-5h-furan-2-one;LGB-VCE
- CBNumber:
- CB8511566
- Molecular Formula:
- C8H12O6
- Molecular Weight:
- 204.18
- MDL Number:
- MFCD09261382
- MOL File:
- 86404-04-8.mol
- MSDS File:
- SDS
| Melting point | 112.0 to 116.0 °C |
|---|---|
| Boiling point | 551.5±50.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| vapor pressure | 0-0Pa at 20-25℃ |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| pka | 8.89±0.40(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C8H12O6/c1-2-13-7-5(11)8(12)14-6(7)4(10)3-9/h4,6,9-11H,2-3H2,1H3/t4-,6+/m0/s1 |
| InChIKey | ZGSCRDSBTNQPMS-UJURSFKZSA-N |
| SMILES | O(CC)C1=C(O)C(=O)O[C@@H]1[C@H](CO)O |
| LogP | -0.8--0.64 at 20-25℃ and pH7 |
| Surface tension | 69-72.4mN/m at 1g/L and 20℃ |
| EWG's Food Scores | 1 |
| FDA UNII | 6MW60CB71P |
| UNSPSC Code | 12352205 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| HS Code | 2936.27.0000 | |||||||||
| NFPA 704 |
|
3-O-Ethyl-L-ascorbic acid price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E0926 | 3-O-Ethyl-L-ascorbic Acid >98.0%(HPLC)(T) | 86404-04-8 | 5g | $42 | 2024-03-01 | Buy |
| TCI Chemical | E0926 | 3-O-Ethyl-L-ascorbic Acid >98.0%(HPLC)(T) | 86404-04-8 | 25g | $144 | 2024-03-01 | Buy |
| TRC | E922013 | 3-O-Ethyl-L-ascorbic Acid | 86404-04-8 | 100mg | $85 | 2021-12-16 | Buy |
| AK Scientific | W8865 | 3-O-Ethyl-L-ascorbic Acid | 86404-04-8 | 10g | $86 | 2021-12-16 | Buy |
| Chem-Impex | 31932 | 3-O-Ethyl-L-ascorbicacid,99%(HPLC) 99%(HPLC) | 86404-04-8 | 25G | $89.6 | 2021-12-16 | Buy |
3-O-Ethyl-L-ascorbic acid Chemical Properties,Uses,Production
Description
3-O-Ethyl-L-ascorbic acid is a product of ascorbic acid-3-O-ethylation. It has a simple molecular structure and is easily absorbed by the skin. After entering the dermis through the stratum corneum of the skin, it is easily decomposed by the biological enzymes in the human body. The effect of ascorbic acid effectively solves the fat solubility problem of ascorbic acid, and is widely used in cosmetics as a whitening agent and antioxidant.
Uses
3-O-Ethyl-L-ascorbic Acid could be a useful stabilizing agent for a para-hydroxyacetophenone solution. It could be a useful stabilizing agent for a para-hydroxyacetophenone solution.
Definition
ChEBI: 3-O-ethyl-l-ascorbic acid (EA) is a butenolide. It is an l-ascorbic acid derivative with an ethyl group at the third carbon position.
Health effects
3-O-ethyl-L-ascorbic acid improves the molecules' stability and its transportation efficacy to the skin, being absorbed faster and better. Additionally, it is less irritating to the skin. Cosmetic case studies demonstrate that they have skin brightening, collagen stimulating, and antioxidant properties.
Mechanism of action
VC ethyl ether penetrates the stratum corneum to reach the melanocytes in the basal layer, inhibits tyrosinase activity, inhibits the formation of melanin, and restores melanin to colorless, thereby effectively whitening the skin. And Chemicalbook and VC ethyl ether can directly participate in the synthesis of collagen and repair skin cell activity after entering the dermis, increasing collagen, so that the skin becomes full and elastic, making the skin delicate and smooth.
Synthesis
The above 3-O-ethyl-5,6-O-isopropylideneascorbic acid 40g dissolved in 200ml of ethanol. 10g of cation-exchange resin was added and was refluxed for 2 hours. The catalyst was removed by an ion exchange resin and concentrated under reduced pressure. After drying, with ethyl acetate: hexane (3: 1) crystallization. After drying, obtained 33.3g 3-O-ethylascorbic acid, yield 94%. It was recrystallized in 100mL ethyl acetate giving 30.6g, yield 87%, mp: 112-114??C.
3-O-Ethyl-L-ascorbic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9304 | 58 |
| QINGDAO HONG JIN CHEMCIAL CO.,LTD. | 532-83657313 18663969289; | hjt@hong-jin.com | China | 227 | 58 |
| Jinan Jianfeng Chemical Co., Ltd | +86-0531-88110457 +86-15562555968 | info@pharmachemm.com | China | 334 | 58 |
| Zhuhai Hairuide Bioscience and Technology Co., Ltd | +8618928027945 | sales3@zhhairuide.com | China | 97 | 58 |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 9875 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 | sales@sdperfect.com | China | 294 | 58 |
| Wuhan Quanjinci New Material Co.,Ltd. | +86-15271838296; +8615271838296 | kyra@quanjinci.com | China | 1512 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 10983 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3882 | 58 |
Related articles
- 3-O-Ethyl-L-ascorbic acid: Benefits and Side effects
- 3-O-Ethyl-L-ascorbic acid is a water-soluble antioxidant that has been used in personal care formulations for many years.
- Dec 13，2023
- Application of 3-O-ethyl-L-ascorbic acid
- 3-O-ethyl-l-ascorbic acid (EA) is an l-ascorbic acid derivative with an ethyl group at the third carbon position.
- Jun 15，2022
View Lastest Price from 3-O-Ethyl-L-ascorbic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-25 | 3-O-Ethyl-L-ascorbic acid VC
86404-04-8
|
US $0.00-0.00 / kg | 1kg | 99.99% | 20 tons | Chongqing Soarwin Technology Co., Ltd | |
 |
2025-04-25 | 3-O-Ethyl-L-ascorbic acid
86404-04-8
|
US $6.00 / kg | 1kg | 99% | 2000KG/Month | HebeiShuoshengImportandExportco.,Ltd | |
 |
2025-04-25 | 3-O-Ethyl-L-ascorbic acid
86404-04-8
|
US $0.00 / kg | 1kg | 97% | 1000 | Hebei Junhua Import and Export Co., LTD |
-
- 3-O-Ethyl-L-ascorbic acid VC
86404-04-8
- US $0.00-0.00 / kg
- 99.99%
- Chongqing Soarwin Technology Co., Ltd
-
- 3-O-Ethyl-L-ascorbic acid
86404-04-8
- US $6.00 / kg
- 99%
- HebeiShuoshengImportandExportco.,Ltd
-
- 3-O-Ethyl-L-ascorbic acid
86404-04-8
- US $0.00 / kg
- 97%
- Hebei Junhua Import and Export Co., LTD
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