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PIM1-IN-1

PIM1-IN-1 Structure
PIM1-IN-1 structure
CAS No.
1417630-95-5
Chemical Name:
PIM1-IN-1
Synonyms
PIM1-IN-1;PIM1 IN 1,PIM1IN1,PIM-1-IN-1;8-Quinolinamine, 2-[8,9-dihydro-7-(2-methoxyethyl)-7H-1,2,4-triazolo[4',3':2,3]pyridazino[4,5-b][1,4]oxazin-3-yl]-N-(4-piperidinylmethyl)-
CBNumber:
CB85540583
Molecular Formula:
C25H30N8O2
Molecular Weight:
474.56
MDL Number:
MFCD31813812
MOL File:
1417630-95-5.mol
Last updated:2024-10-23 13:36:13
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PIM1-IN-1 Properties

Density 1.45±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 45 mg/mL (94.82 mM; Need ultrasonic)
pka 10.48±0.10(Predicted)
form Solid
color Light yellow to yellow

PIM1-IN-1 Chemical Properties,Uses,Production

Biological Activity

PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity[1]. PIM1-IN-1 (Compound 42) exhibits antiproliferative activity, with GI50 of 1.48 μM for melanoma cell line SKMEL-19. PIM1-IN-1 has significant synergistic effect combined with different antitumoral agents in different tumor cell lines[1]. PIM1-IN-1 (2.5, 5, or 10 μM, 24 hours) induces apoptosis in SKMEL19 cells[1]. PIM1-IN-1 shows cceptable clearance of 1.26 L/h/kg in BALB-C mice[1].

References

[1]. Martínez-González S, et al. Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors. Eur J Med Chem. 2019 Feb 19;168:87-109.

PIM1-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

PIM1-IN-1 Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32072 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38466 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19863 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7887 56
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8012 62
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24648 58
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 15162312715 sales@szzxbio.com China 2991 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
Changsha Fuzhen Biotechnology Co.，LTD 13823398779 18670069958 313359644@qq.com China 3263 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
ShangHai Biochempartner Co.,Ltd 62
Fan De(Beijing) Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Suzhou Zhixin Biotechnology Co., Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Changsha Fuzhen Biotechnology Co.，LTD 58

View Lastest Price from PIM1-IN-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PIM1-IN-1 pictures 2024-10-24 PIM1-IN-1
1417630-95-5
 US $2360.00-1140.00 / mg 10g TargetMol Chemicals Inc.
  • PIM1-IN-1 pictures
  • PIM1-IN-1
    1417630-95-5
  • US $2360.00-1140.00 / mg
  • TargetMol Chemicals Inc.
PIM1-IN-1 PIM1 IN 1,PIM1IN1,PIM-1-IN-1 8-Quinolinamine, 2-[8,9-dihydro-7-(2-methoxyethyl)-7H-1,2,4-triazolo[4',3':2,3]pyridazino[4,5-b][1,4]oxazin-3-yl]-N-(4-piperidinylmethyl)- 1417630-95-5