WJ460
- CAS No.
- 1415251-36-3
- Chemical Name:
- WJ460
- Synonyms
- WJ460;WJ-460.WJ460;WJ-460.WJ460;WJ 460;WJ460, 10 mM in DMSO;3-(3-(2-Methoxyphenyl)-4-oxothiazolidin-2-yl)-N-(4-phenylbutyl)benzamide;Benzamide, 3-[3-(2-methoxyphenyl)-4-oxo-2-thiazolidinyl]-N-(4-phenylbutyl)-;3-[3-(2-methoxyphenyl)-4-oxo-1,3-thiazolidin-2-yl]-N-(4-phenylbutyl)benzamide;WJ460 3-(3-(2-Methoxyphenyl)-4-oxothiazolidin-2-yl)-N-(4- phenylbutyl)benzamide
- CBNumber:
- CB85574272
- Molecular Formula:
- C27H28N2O3S
- Molecular Weight:
- 460.59
- MDL Number:
- MFCD32201068
- MOL File:
- 1415251-36-3.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
WJ460 Chemical Properties,Uses,Production
Uses
WJ460 is a potent inhibitor of myoferlin (MYOF) that interacts directly with MYOF. WJ460 inhibits the migration and growth, induces cell cycle arrest, mitochondrial autophagy, lipid peroxidation and ferroptosis in tumor cells. WJ460 has anti-tumor activity[1][2].
in vivo
WJ460 (5-10mg/kg; intraperitoneal injection; single dose) has antitumor activity in nude mouse breast cancer metastasis model[2].
| Animal Model: | MDA-MB-231-Luciferase cells treated athymic nude mice[2] |
| Dosage: | 5 and 10mg/kg |
| Administration: | Intraperitoneal injection (i.p.); single dose |
| Result: | Significantly inhibited breast cancer pulmonary metastasis in a concentration-dependent manner. Inhibited the proliferation of MDA-MB-231 cells. Increased mouse overall survival. |
References
[1] Rademaker G, et al. Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells. Redox Biol. 2022 Jul;53:102324. DOI:10.1016/j.redox.2022.102324
[2] Zhang T, et al. A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer. Nat Commun. 2018 Sep 13;9(1):3726. DOI:10.1038/s41467-018-06179-0
WJ460 Preparation Products And Raw materials
Raw materials
Preparation Products
WJ460 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 3906 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9323 | 58 |
