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BRD 0476

BRD 0476 Structure
BRD 0476 structure
CAS No.
1314958-91-2
Chemical Name:
BRD 0476
Synonyms
ML187;ML-187;ML 187;BRD 0476;1,4-Benzodioxin-6-sulfonamide, 2,3-dihydro-N-methyl-N-[[(2R,3R)-3,4,5,6-tetrahydro-5-[(1S)-2-hydroxy-1-methylethyl]-3-methyl-10-[[(1-naphthalenylamino)carbonyl]amino]-6-oxo-2H-1,5-benzoxazocin-2-yl]methyl]-
CBNumber:
CB85867318
Molecular Formula:
C35H38N4O8S
Molecular Weight:
674.76
MDL Number:
MOL File:
1314958-91-2.mol
Last updated:2024-10-28 16:48:35
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BRD 0476 Properties

Density 1.364±0.06 g/cm3(Predicted)
pka 13.37±0.60(Predicted)

BRD 0476 Chemical Properties,Uses,Production

Description

BRD0476, also known as ML187, is a novel suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell survival. However, unlike common JAK-STAT pathway inhibitors, BRD0476 inhibits JAK-STAT signaling without suppressing the kinase activity of any JAK. BRD0476 suppresses cytokine-induced β-cell apoptosis.

Definition

ChEBI: 1-[(2R,3R)-2-[[2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl(methyl)amino]methyl]-5-[(2S)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-3-(1-naphthalenyl)urea is a member of naphthalenes.

BRD 0476 Preparation Products And Raw materials

Raw materials

Preparation Products

BRD 0476 Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19884 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19703 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12000 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58

View Lastest Price from BRD 0476 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BRD0476 pictures 2024-10-28 BRD0476
1314958-91-2
 US $2500.00-1980.00 / mg 10g TargetMol Chemicals Inc.
  • BRD0476 pictures
  • BRD0476
    1314958-91-2
  • US $2500.00-1980.00 / mg
  • TargetMol Chemicals Inc.
BRD 0476 ML 187 ML187 ML-187 1,4-Benzodioxin-6-sulfonamide, 2,3-dihydro-N-methyl-N-[[(2R,3R)-3,4,5,6-tetrahydro-5-[(1S)-2-hydroxy-1-methylethyl]-3-methyl-10-[[(1-naphthalenylamino)carbonyl]amino]-6-oxo-2H-1,5-benzoxazocin-2-yl]methyl]- 1314958-91-2