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DOTMA

DOTMA structure

CAS No.: 104872-42-6

Chemical Name:: DOTMA

Synonyms: R-DOTMA-Cl;1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt);N,N,N-Trimethyl-2,3-bis(octadec-9-en-1-yloxy)propan-1-aminium chloride;1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt)(DOTMA);(1 cis trans) -1,2-dioleoxy-3- (trimethylammonium) propane gas salt (cis trans DOTMA-CL)

CBNumber:: CB86188272

Molecular Formula:: C42H84ClNO2

Molecular Weight:: 670.59

MDL Number:

MOL File:: 104872-42-6.mol

Last updated:2025-04-17 18:22:24

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DOTMA Properties

storage temp.	-20°C
solubility	DMSO:50.0(Max Conc. mg/mL);0.03(Max Conc. mM)
form	Solid
color	White to light yellow
InChIKey	LDGWQMRUWMSZIU-UHFFFAOYSA-M
SMILES	C(C[N+](C)(C)C)(OCCCCCCCCC=CCCCCCCCC)COCCCCCCCCC=CCCCCCCCC.[Cl-]
UNSPSC Code	12352211
NACRES	NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

DOTMA Chemical Properties,Uses,Production

Description

DOTMA is one of the first cationic lipid used for gene transfection. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome.

Uses

DOTMA is used for drug delivery and gene transfection. When used as a component of liposomes, it is used to encapsulate siRNAs, miRNAs and oligonucleotides, etc., to form carrier liposomes (LPX), which are used in anticancer vaccine research.DOTMA has shown good gene transfection effects both in vitro and in vivo. It can also be used as a development of new visualisers.

Biochem/physiol Actions

DOTMA is a cationic lipid, used as a non-viral vector for gene therapy. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome - cell membrane interaction.

in vivo

DOTMA shows high intravenous transfection activity in CD-1 mouse^[3].

DOTMA Preparation Products And Raw materials

Raw materials

Preparation Products

DOTMA Suppliers

Global( 63)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
XIAMEN SINOPEG BIOTECH CO., LTD.	+86-0592-7761068 +8617350879715	changaiwei@sinopeg.com	China	176	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Chongqing Soarwin Technology Co., Ltd	+86-19132938950 +86-19132938950	crystal@sorawin.cn	China	360	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Shochem(Shanghai) Co.,Ltd	86-21-50800795	info@shochem.com	CHINA	288	58
Creative Enzymes	1-516-855-7709	info@creative-enzymes.com	United States	8748	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Shochem(Shanghai)Co.,Ltd	+86-021-51783479 +86-13816874662	info@shochem.com	China	307	58

Supplier	Advantage
XIAMEN SINOPEG BIOTECH CO., LTD.	58
BOC Sciences	58
Chongqing Soarwin Technology Co., Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Shochem(Shanghai) Co.,Ltd	58
Creative Enzymes	58
TargetMol Chemicals Inc.	58
LEAP CHEM CO., LTD.	58
Aladdin Scientific	58
Shochem(Shanghai)Co.,Ltd	58

View Lastest Price from DOTMA manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-25	DOTMA 104872-42-6	US $0.00-0.00 / kg	1kg	99.99%	20 tons	Chongqing Soarwin Technology Co., Ltd
2025-03-31	DOTMA 104872-42-6	US $0.00-0.00 / g	1g	98%	1g/bottle , 10g/bottle, 100g/bottle	XIAMEN SINOPEG BIOTECH CO., LTD.
2024-10-24	DOTMA 104872-42-6	US $37.00-89.00 / mg		98.22%	10g	TargetMol Chemicals Inc.

DOTMA
104872-42-6
US $0.00-0.00 / kg
99.99%
Chongqing Soarwin Technology Co., Ltd

DOTMA
104872-42-6
US $0.00-0.00 / g
98%
XIAMEN SINOPEG BIOTECH CO., LTD.

DOTMA
104872-42-6
US $37.00-89.00 / mg
98.22%
TargetMol Chemicals Inc.

DOTMA Spectrum

DOTMA(104872-42-6)¹HNMR

104872-42-6(DOTMA)Related Search:

DLinDMA N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE DOTAP DODMA

1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt) N,N,N-Trimethyl-2,3-bis(octadec-9-en-1-yloxy)propan-1-aminium chloride R-DOTMA-Cl 1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt)(DOTMA) (1 cis trans) -1,2-dioleoxy-3- (trimethylammonium) propane gas salt (cis trans DOTMA-CL) 104872-42-6