MK-886
- CAS No.
- 118414-82-7
- Chemical Name:
- MK-886
- Synonyms
- MK866;MK-886;CS-1988;CGS-81585;L-663,536;MK-886 (Base);MK-886 (L-663,536);MK-886 (Free Base);MK886, Lipoxygenase inhibitor;3-[1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid
- CBNumber:
- CB8671381
- Molecular Formula:
- C27H34ClNO2S
- Molecular Weight:
- 472.08
- MDL Number:
- MFCD00876710
- MOL File:
- 118414-82-7.mol
- MSDS File:
- SDS
| Melting point | 295-297°C |
|---|---|
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: 32 mg/mL |
| form | White solid. |
| color | white |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| FDA UNII | 080626SQ8C |
MK-886 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 475889 | MK-886 - CAS 118414-82-7 - Calbiochem | 118414-82-7 | 5MG | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 21753 | MK-886 ≥98% | 118414-82-7 | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 21753 | MK-886 ≥98% | 118414-82-7 | 5mg | $85 | 2024-03-01 | Buy |
| Cayman Chemical | 21753 | MK-886 ≥98% | 118414-82-7 | 10mg | $150 | 2024-03-01 | Buy |
| Cayman Chemical | 21753 | MK-886 ≥98% | 118414-82-7 | 25mg | $330 | 2024-03-01 | Buy |
MK-886 Chemical Properties,Uses,Production
Description
MK-886 (118414-82-7) is an inhibitor of leukotriene biosynthesis(IC50 = 2.5 nM in human PMN)1 via 5-lipoxygenase-activating protein (FLAP) inhibition (IC50 = 30 nM)2. MK-886 also inhibits PPARα (80% inhibition at 10 μM).3
Chemical Properties
White Solid
Uses
Binds to 5-lipoxygenase-activating protein with high affinity and prevents the activation of 5-lipoxygenase, thus inhibiting the biosynthesis of leukotrienes.
Uses
MK-886 is a potent and selective inhibitor of FLAP and Cox-1.
Definition
ChEBI: A member of the class of indoles that is 1H-indole substituted by a isopropyl group at position 5, a tert-butylsulfanediyl group at position 3, a 4-chlorobenzyl group at position 1 and a 2-carboxy-2-methylpropyl group at pos tion 2. It acts as an inhibitor of arachidonate 5-lipoxygenase.
Biological Activity
An inhibitor of leukotriene biosynthesis (IC 50 = 3 nM in human polymorphonuclear leukocytes). Acts by inhibiting 5-lipoxygenase-activating protein (FLAP) (IC 50 = 30 nM for inhibition of [ 125 I]-L-691,678 photoaffinity labelling). Also moderately potent PPAR α antagonist (IC 50 = 0.5-1 μ M). Orally active in vivo .
storage
Store at RT
References
References/Citations 1) Gillard et al (1989) L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor; Can. .J. Physiol .Pharmacol. 67 456 2) Evans et al (1991) 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors; Mol. Pharmacol. 40 22 3) Kehrer et al (2001) Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886; Biochem. J. 356 899
MK-886 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29810 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 |
