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ChemicalBook >> CAS DataBase List >>2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE

2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE

2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE Structure
2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE structure
CAS No.
84050-22-6
Chemical Name:
2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE
Synonyms
Terazosin-004-HCl;DPQ (hydrochloride);Terazosin Impurity5;2-PADQZ hydrochloride;Terazosin Impurity 6 HCl;Terazosin Impurity 3 HCl;2PADQZ hydrochloride,2 PADQZ hydrochloride;2-PIPERAZINYL-4-AMINO-6,7-DIMETHOXYQUINAZOLINEHCL;2-Piperazine-4-amino-6,7-dimethoxy quinazoline HCl;Piperazine amino dimethoxy quinaoline hydrochloride
CBNumber:
CB8686460
Molecular Formula:
C14H20ClN5O2
Molecular Weight:
325.79
MDL Number:
MFCD03840840
MOL File:
84050-22-6.mol
Last updated:2025-04-18 09:52:56
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2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE Properties

CAS DataBase Reference 84050-22-6(CAS DataBase Reference)

2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation CHM0157599 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINAOLINE HYDROCHLORIDE 95.00% 84050-22-6 1G $945.95 2021-12-16 Buy
AHH MT-21477 2-Piperazine-4-amino-6,7-dimethoxyquinolinehydrochloride 99% 84050-22-6 10g $868 2021-12-16 Buy
Product number Packaging Price Buy
CHM0157599 1G $945.95 Buy
MT-21477 10g $868 Buy

2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

DPQ hydrochloride is a blood-brain barrier permeable and selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD+/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ hydrochloride inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ hydrochloride can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases[1][2][3].

in vivo

DPQ hydrochloride (10 mg/kg; intraperitoneal injection; single dose; 6 h) significantly attenuates lung inflammation, neutrophil infiltration, and vascular leakage in LPS-induced acute lung injury model of C57BL/6 mice, inhibiting NF-κB pathway activation[2].
DPQ hydrochloride (10 mg/kg; intraperitoneal injection; single dose; 4 weeks) improves cardiac function and reduced apoptosis and oxidative stress in myocardial infarction model of Wistar rats[3].

Animal Model:LPS-Induced Acute Lung Injury Model in C57BL/6 mice (male, 8-10 weeks old)[2]
Dosage:10 μg/kg (dissolved in 0.01% DMSO (PBS)
Administration:Intraperitoneal injection, 30 min after LPS chanllenge (7.5 mg/kg; ip; single dose)
Result:Reduced neutrophil infiltration (50% decrease), MPO activity (40% decrease), and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) in lungs. Restored vascular permeability (Evans blue extravasation reduced by 35%), and inhibited apoptotic cell death (TUNEL-positive cells decreased by 45%).
Suppressed NF-κB activation with reduced IkB-α degradation and p65 phosphorylation.
Animal Model:Wistar rats (male, 4 months old) + MI via coronary artery ligation[3]
Dosage:10 mg/kg (dissolved in DMSO)
Administration:Intraperitoneal injection, single dose immediately after MI induction
Result:Improved cardiac function (FS increased by 25%, EDD/ESD reduced by 15%), decreased apoptotic cardiomyocytes (TUNEL-positive cells reduced by 40%), and suppressed cleaved caspase-3 and PARP1 expression. Oxidative stress markers (O2-, nitrotyrosine) were reduced by 30-40% in infarcted myocardium.

IC 50

PARP-1

References

[1] Meli E, et al. Differential role of poly (ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro. Mol Cell Neurosci. 2004;25 (1) :172-180. DOI:10.1016/j.mcn.2003.09.016
[2] Wang G, et al. PARP-1 inhibitor, DPQ, attenuates LPS-induced acute lung injury through inhibiting NF-κB-mediated inflammatory response. PLoS One. 2013 Nov 21;8 (11) :e79757. DOI:10.1371/journal.pone.0079757
[3] Wang J, et al. Inhibition of poly (ADP-ribose) polymerase and inducible nitric oxide synthase protects against ischemic myocardial damage by reduction of apoptosis. Mol Med Rep. 2015 Mar;11 (3) :1768-76. DOI:10.3892/mmr.2014.2977

2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE Suppliers

Global( 53)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30231 58
Unipharm pharmaceutical industry Co., Ltd 		536-8266195 +8613953676784 lee@unipharm-sd.com China 1202 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52849 58
PT CHEM GROUP LIMITED 		+86-85511178; +86-85511178; peter68@ptchemgroup.com China 35425 58
Moxin Chemicals 		+8617320513646 mike@molcoo.com China 9634 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Mainchem Co., Ltd. +86-0592-6210733 sale@mainchem.com China 32343 55
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
Unipharm pharmaceutical industry Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
PT CHEM GROUP LIMITED 		58
Moxin Chemicals 		58
Amadis Chemical Company Limited 		58
Mainchem Co., Ltd. 55
BOC Sciences 65

View Lastest Price from 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-PADQZ hydrochloride pictures 2024-11-19 2-PADQZ hydrochloride
84050-22-6
 US $117.00-388.00 / mg 98.62% 10g TargetMol Chemicals Inc.

84050-22-6(2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE)Related Search:

2-Piperazine-4-amino-6,7-dimethoxyquinazoline Terazosin impurity 1-[4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl]-5-hydroxy-1-pentanone Prazosin hydrochloride Piperazine, 1-[[(2R)-tetrahydro-2-furanyl]carbonyl]- (9CI)
Terazosin hydrochloride dihydrate [4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl][(5S)-tetrahydro-5-Methyl-2-furanyl]Methanone 1-(2-Furoyl)piperazine NSC 351869 [4-(4-AMino-7-hydroxy-6-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone
Terazosin EP IMpurity D 6,7-DiMethoxy-2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)quinazolin-4(1H)-one 2,2'-(1,4-Piperazinediyl)bis[6,7-diMethoxy-4-quinazolinaMine] (R)-Terazosin 2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-diMethoxybenzoic Acid (Donepezil IMpurity)
Terazosin IMpurity J [4-(4-AMino-6-hydroxy-7-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone Terazosin EP Impurity O

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2-PIPERAZINYL-4-AMINO-6,7-DIMETHOXYQUINAZOLINEHCL 4-Amino-2-piperazin-6,7-dimethoxyquinolinehydrochloride 2-Piperazinyl-6,7-dimethoxyquinazolin-4-amine hydrochlorode Piperazine amino dimethoxy quinaoline hydrochloride 2-Piperazine-4-amino-6,7-dimethoxy quinazoline HCl 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE 2-Piperazinyl-4-amino-6,7-dimethoxyquinazoline Hydrochloride 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINAOLINE HYDROCHLORIDE 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXYQUINAZOLINE(WXG00079) Terazosin-004-HCl Terazosin Impurity5 6,7-dimethoxy-N-(1-piperazinyl)-2-quinolinamine hydrochloride 2-PADQZ hydrochloride 2PADQZ hydrochloride,2 PADQZ hydrochloride 6,7-Dimethoxy-N-(piperazin-1-yl)quinolin-2-amine hydrochloride DPQ (hydrochloride) Terazosin Impurity 6 HCl Terazosin Impurity 3 HCl 84050-22-6 C14H19N5O2HCl