Silychristin
- CAS No.
- 33889-69-9
- Chemical Name:
- Silychristin
- Synonyms
- SILYCRISTIN;Silicristin;SILICHRISTIN;SILYCHRISTIN;Silymarin II;Christianity;Silychristin A;Silychristin，SC;Silychristin-RM;SILYCHRISTIN hplc
- CBNumber:
- CB8687836
- Molecular Formula:
- C25H22O10
- Molecular Weight:
- 482.44
- MDL Number:
- MFCD00883715
- MOL File:
- 33889-69-9.mol
| Melting point | 174～176℃ |
|---|---|
| Boiling point | 782.0±60.0 °C(Predicted) |
| Density | 1.578±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Acetone (Slightly), Methanol (Slightly) |
| pka | 7.39±0.60(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | practically insoluble in water |
| Stability | Hygroscopic |
| FDA UNII | LK279ER14X |
Silychristin price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2581 | Silychristin Milk Thistle component, ≥95% (HPLC) | 33889-69-9 | 5MG | $257 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHL89281 | Silychristin phyproof? Reference Substance | 33889-69-9 | 10MG | $288 | 2024-03-01 | Buy |
| Sigma-Aldrich | 51681 | Silychristin analytical standard | 33889-69-9 | 10mg | $549 | 2022-05-15 | Buy |
| Usbiological | 300975 | Silychristin | 33889-69-9 | 10mg | $448 | 2021-12-16 | Buy |
| TRC | S465880 | Silychristin | 33889-69-9 | 10mg | $340 | 2021-12-16 | Buy |
Silychristin Chemical Properties,Uses,Production
Chemical Properties
Silychristin is the second most abundant flavonolignan in the silymarin complex, which is usually produced by the acetone extraction of Silybum marianum (L.) Gaertn. (milk thistle) fruits. Natural silychristin is a mixture of two diastereomers (silychristin A and B, 95:5). Isosilychristin is a silychristin isomer mainly occurring in wild milk thistle. At the same time, 2,3-dehydrosilychristin is a product of its aerial oxidation detectable in silymarin preparations. In contrast, anhydrosilychristin is a dehydrated product obtained by treating silychristin with hydrochloric acid in hot ethanol[1].
Uses
Silychristin is a new natural product has been isolated from silymarin, the hepatoprotective extract of milk thistle (Silybum marianum) fruits. Silychristin has been shown to be an antihepatotoxic flavonolignan.
Definition
ChEBI: A flavonolignan isolated from Silybum marianum and has been shown to exhibit inhibitory activities against lipoxygenase and prostaglandin synthetase.
benefits
Like other components of the silymarin complex, silychristin has antioxidant properties. Its potential to scavenge the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical is nearly 14× higher than that of silybin (considered “the active component of silymarin”) and approximately 1.5× lower than that of its oxidized derivative 2,3-dehydrosilybin. This compound exhibited a higher antioxidant capacity than “traditional” antioxidants.
Silychristin was able to inhibit α-glucosidase, exhibiting a potential in the treatment of diabetes mellitus type II. Furthermore, it increased insulin secretion and decreased glucose content in induced type I diabetic rats and Mesocestoides vogae larvae.
Silychristin also displayed concentration-dependent anti-inflammatory activity and inhibited collagenase much more efficiently than its standard inhibitor 1,10-phenanthroline, thus showing a potential application in cosmeceuticals. In a transdermal study, silychristin penetrated the human skin but did not reach the basolateral side. Both acute cytotoxic and genotoxic doses were higher than 100 μM for blood platelets, peripheral blood mononuclear cells, and alveolar basal epithelial cells. Moreover, at these concentrations, this compound protected mitochondria against spontaneous DNA damage. Moreover, copper and iron chelation was also affected by silychristin, which could have implications for the absorption of these ions in the gastrointestinal tract[1].
in vitro
Silychristin exhibits a strong inhibition of MCT8-mediated T3 uptake with an IC50 of 110 nM in MCT8 overexpressing MDCK1-cells.
It causes no cytotoxic for fibroblasts.
Silychristin (6.5-75 μM; 24 hours) diminishes UVA toxicity and reduces ROS generation, and the protective effect is dose-dependent.
Silychristin (12.5μM, 25μM) reduces the metalloproteinase-1 (MMP-1) level in cells.
target
NADPH-oxidase | P450 (e.g. CYP17)
target
MCT8
storage
Powder
-20°C 3 years
4°C 2 years
In solvent
-80°C 2 years
-20°C 1 year
References
[1] Simona Dobiasová. “Multidrug Resistance Modulation Activity of Silybin Derivatives and Their Anti-inflammatory Potential.” Antioxidants 9 5 (2020).
Silychristin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
Related articles
- The new research on Silychristin
- Silychristin is the second most abundant flavonolignan (after silybin) present in the fruits of Silybum marianum.
- Apr 29，2024
View Lastest Price from Silychristin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Silychristin
33889-69-9
|
US $43.00-98.00 / mg | 99.74% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-03-28 | Silychristin
33889-69-9
|
US $0.00 / kg | 25kg | 30% 50%(HPLC) 80%(UV) | Inquiry | PNP Biotech Co. Ltd | |
 |
2023-02-24 | Silychristin
33889-69-9
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Silychristin
33889-69-9
- US $43.00-98.00 / mg
- 99.74%
- TargetMol Chemicals Inc.
-
- Silychristin
33889-69-9
- US $0.00 / kg
- 30% 50%(HPLC) 80%(UV)
- PNP Biotech Co. Ltd
-
- Silychristin
33889-69-9
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
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