Imipenem

Imipenem Properties

Melting point	193-198°C
Boiling point	567℃
RTECS	CL5446516
Flash point	>110°(230°F)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	H2O: >5mg/mL
pka	pKa 3.2/9.9(H2O,t = 25) (Uncertain)
form	powder
color	white to beige
Water Solubility	Soluble in water at 5mg/ml
CAS DataBase Reference	74431-23-5(CAS DataBase Reference)
NCI Dictionary of Cancer Terms	imipenem
FDA UNII	71OTZ9ZE0A
NCI Drug Dictionary	imipenem

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
WGK Germany	3
HS Code	2941906000

Imipenem price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	I0160	Imipenem monohydrate ≥98% (HPLC)	74431-23-5	5mg	$137.6	2024-03-01	Buy
Sigma-Aldrich	I0160	Imipenem monohydrate ≥98% (HPLC)	74431-23-5	25mg	$682	2024-03-01	Buy
Sigma-Aldrich	I0090000	Imipenem European Pharmacopoeia (EP) Reference Standard	74431-23-5	I0090000	$153	2024-03-01	Buy
Alfa Aesar	J66749	Imipenem monohydrate, 95%	74431-23-5	5mg	$97.65	2024-03-01	Buy
Alfa Aesar	J66749	Imipenem monohydrate, 95%	74431-23-5	25mg	$247	2024-03-01	Buy

Product number	Packaging	Price	Buy
I0160	5mg	$137.6	Buy
I0160	25mg	$682	Buy
I0090000	I0090000	$153	Buy
J66749	5mg	$97.65	Buy
J66749	25mg	$247	Buy

Imipenem Chemical Properties,Uses,Production

Chemical Properties

Imipenem (N-formimidoylthienamycin monohydrate) is a crystalline derivative of thienamycin, which is produced by Streptomyces cattleya. Its chemical name is (5 R,6S)-3-[[2-(formimidoylamino)ethyl]thio]-6-[( R)-1-hydroxyethyl ]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate. It is an off-white, nonhygroscopic crystalline compound with a molecular weight of 317.37. It is sparingly soluble in water and slightly soluble in methanol.

Discovery

Imipenem is an intravenous β-lactam antibiotic discovered by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in the mid-1970s. Imipenem was patented in 1975 and approved for medical use in 1985.

Imipenem has a broad spectrum of activity against aerobic and anaerobic, Gram-positive and Gram-negative bacteria. It is particularly important for its activity against Pseudomonas aeruginosa and the Enterococcus species. It is not active against MRSA, however.

Broad-spectrum antibiotic

Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.It is stable to many beta-lactamases. Similar compounds include meropenem, known for having greater activity against Gram negative bacteria, and the newer ertapenem which exhibits a longer half-life due to increased binding to plasma proteins.

Imipenem acts as an antimicrobial through the inhibition of cell wall synthesis of various gram-positive and gram-negative bacteria.This inhibition of cell wall synthesis in gram-negative bateria is attained by binding to penicillin-binding proteins (PBPs).

Chemical Properties

Off-White Solid

Uses

antidiabetic

Uses

antiulcer

Uses

An extremely broad-spectrum semi-synthetic antibiotic

Uses

Imipenem has a broad spectrum of antimicrobial action, which includes most clinically significant microorganisms: Gram-positive, Gram-negative, aerobic, and anaerobic. It is resistant with respect to most beta-lactamases of Gram-positive and Gram-negative bacteria. It is used for bacterial infections of the lower respiratory tract, infections of the urinary and sexual tracts, infections of bones, joints, skin, soft tissues, intraabdominal and gynecological infections, bacterial septicemia, and endocarditis.
Imipenem undergoes enzymatic inactivation in the kidneys. In order to avoid this problem, it is used in a 1:1 ratio in combination with cilastatin—the sodium salt of [R-[R,S-(Z)]]-7-[(2- amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)aminocarbonyl-2-heptenoic acid (32.1.3.6), which inhibits metabolisms of imipenem in the kidneys. This combination of two compounds is also used in medicine under the name primaxin.

Definition

ChEBI: Imipenem hydrate is a member of carbapenems. It contains an imipenem.

General Description

Chemical structure: ?-lactam

Biochem/physiol Actions

Imipenem is found effective against gram positive and negative aerobes and anaerobes. Imipenem is often combined with cilastatin, to inhibit its metabolism in kidney.

Synthesis

Imipenem, [5R-[5|á,6|á(R)]]-6-(1-hydroxyethyl)-3-[[2-[(iminomethyl)amino] ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-en-2-carboxylic acid (32.1.3.1), is the only carbapenem presently used in clinics. It is synthesized from thienamycin isolated from Streptomyces cattleya by reacting it with the methyl formimidate.

Synthesis_74431-23-5

Unlike penicillins and cephalosporins, which have a side aminoacyl group joined to the betalactam ring, imipenem has a |á-hydroxyethyl side chain. Significant resistance to hydrolysis by beta-lactamases is observed in this compound, evidently thanks to the trans-configuration of the side chain, while the side chain of penicillins and cephalosporins have a cis configuration.

Imipenem Preparation Products And Raw materials

Raw materials

Silica glass 6-Aminopenicillanic acid INSTANT BUFFER S70, PH7.0 (ACC. TO SOERENSEN)(50PACKS) Trimethacrylate Benzyl ester

N,N-Dimethylformamide Sodium bisulfite water solution MERCURIC ACETATE Sodium nitrite Tetrahydrofuran

Ammonium chloride VINYLACETIC ACID Acetic acid Ammonium acetate Iodomethane

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Preparation Products

Imipenem Suppliers

Global( 273)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618092446649	sarah@tnjone.com	China	1143	58
Apeloa production Co.,Limited	+8619933239880	admin@apcl.com.cn	China	852	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	802	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15319487004	1015@dideu.com	China	2127	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Apeloa production Co.,Limited	58
Henan Tianfu Chemical Co.,Ltd.	55
Speranza Chemical Co., Ltd.	55
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from Imipenem manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Imipenem 74431-23-5	US $1.00 / g	1g	0.98	1000	Apeloa production Co.,Limited
2024-11-15	Imipenem monohydrate 74431-23-5	US $53.00 / mg		99.94%	10g	TargetMol Chemicals Inc.
2024-11-05	Imipenem 74431-23-5	US $1.00-1.00 / KG	1g	99%	50tons	Shaanxi Dideu Medichem Co. Ltd

Imipenem
74431-23-5
US $1.00 / g
0.98
Apeloa production Co.,Limited

Imipenem monohydrate
74431-23-5
US $53.00 / mg
99.94%
TargetMol Chemicals Inc.

Imipenem
74431-23-5
US $1.00-1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

Imipenem Spectrum

Imipenem(74431-23-5)MS

74431-23-5(Imipenem)Related Search:

Ethanol Glucosamine IMIPEMIDE IMIPENEM IMIPENEN N-FORMIMIDOYLTHIENAMYCIN TIENAMYCIN,Imipenem Sulfamic acid Acetaminophen

Ethyl acrylate EC 2.6.1.2 Ethyl acetate Ethyl formate Ethyl propionate

2-(METHYLSULFONYL)ETHANOL Ethylbenzene Ethylparaben (5R,6S)-3-[(Diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester INTERMEDIANTE FOR IMIPENEM

Imipenem Impurity 3 Imipenem Impurity 4 Imipenem EP Impurity B

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Imipenem hydrate Imipenem Monohydrate (100 mg) Crude Grade of Imipenem (5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate, Primaxin monohydrate, Tienam monohydrate (6 R,7 R)-7-AMIMO-8-OXO-3-(1-PROPENYL)-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID Monohydrate (5R,6S)-3-((2-Formimidamidoethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate Primaxin monohydrate Tienam monohydrate Imipenem monohydrate, >=98% Imipenem Monohydrate, Antibiotic for Culture Media Use Only (6 R,7 R)-7-AMIMO-8-OXO-3-(1-PROPENYL)-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID 5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-AMINO-8-OXO-3-(1-PROPENYL)-, (6R,7R)- (6 R ,7 R ) - 7-AMIMO-8-OXO-3-(1-PROPENYL)-5-THIA-1-AZABICYLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-[[2-[(iminomethyl) amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate Imipenem lmipemide MK-0787 (5R,6S)-3-((2-Formimidamidoethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.]hept-2-ene-2-carboxylic acid hydrate [5R-[5α，6α(R^<*>^)]]-6-(1-hydroxyethyl)-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate Imipenem n-Hydrate CS-342 EOS-61603 IMIPEMIDE MONOHYDRATE N-Formimidoyl thienamycin monohydrate Imipenem USP/EP/BP Imipenem monohydrate (High purity) Imipenem 1-hydrate ?mipenem monohydrate Crude (6R,7R)-7-AMIMO-8-OXO-3-(1-PROPENYL)-5-THIA-1-azabicyclo[4.2... Imipenem MonohydrateQ: What is Imipenem Monohydrate Q: What is the CAS Number of Imipenem Monohydrate Q: What is the storage condition of Imipenem Monohydrate Imipenem crude(monohydrate non sterile) Imipenem crude(monohydrate non sterile) Imipenem Monohydrate (1337809) Imipenem Monohydrate≥ 96% (HPLC) bacteria,Inhibitor,N-Formimidoyl thienamycin,P. aeruginosa,ntibiotic,MK0787,Imipenem monohydrate,MK 0787,MK-0787,infection,inhibit,Bacterial,Antibiotic,thienamycin Imipenem（b） lmipenem monohydrate 74431-23-5 C12H17N3O4SH2O ROXIT Intermediates & Fine Chemicals Pharmaceuticals

Imipenem Properties

SAFETY

Risk and Safety Statements

Imipenem price More Price(38)

Imipenem Chemical Properties,Uses,Production

Chemical Properties

Discovery

Broad-spectrum antibiotic

Chemical Properties

Uses

Uses

Uses

Uses

Definition

General Description

Biochem/physiol Actions

Synthesis

Imipenem Preparation Products And Raw materials

Raw materials

Preparation Products

Imipenem Suppliers

Related articles

View Lastest Price from Imipenem manufacturers

Imipenem Spectrum

74431-23-5(Imipenem)Related Search: