AC-SER-ASP-LYS-PRO-OH
- CAS No.
- 127103-11-1
- Chemical Name:
- AC-SER-ASP-LYS-PRO-OH
- Synonyms
- AC-SDKP;GORALATIDE;Acetyl-SDKP;SERASPENIDE;AC-SDKP-DELTA;Thymosin β4 (1-4);Thymosin β4 (1-4);AC-SER-ASP-LYS-PRO;Thymosin beta4 (1-4);AC-SER-ASP-LYS-PRO-O
- CBNumber:
- CB8704926
- Molecular Formula:
- C20H33N5O9
- Molecular Weight:
- 487.5
- MDL Number:
- MFCD00076849
- MOL File:
- 127103-11-1.mol
- MSDS File:
- SDS
Boiling point | 992.0±65.0 °C(predicted) |
---|---|
Density | 1.382±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) |
storage temp. | −20°C |
solubility | Soluble in DMSO |
pka | 3.39±0.20(predicted) |
form | Solid |
color | White to off-white |
Water Solubility | Soluble in water at 2mg/ml |
Sequence | H-Gln-Lys-Leu-Val-Phe-Phe-Ala-OH |
FDA UNII | H041538E9P |
AC-SER-ASP-LYS-PRO-OH price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | J66430 | N-Acetyl-Ser-Asp-Lys-Pro | 127103-11-1 | 5mg | $64.6 | 2023-06-20 | Buy |
Biosynth Carbosynth | FA108367 | Ac-Ser-Asp-Lys-Pro-OH | 127103-11-1 | 5mg | $131 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA108367 | Ac-Ser-Asp-Lys-Pro-OH | 127103-11-1 | 10mg | $228 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA108367 | Ac-Ser-Asp-Lys-Pro-OH | 127103-11-1 | 25mg | $456 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | PEP0002574 | N-ACETYL-SER-ASP-LYS-PRO 95.00% | 127103-11-1 | 5MG | $718.47 | 2021-12-16 | Buy |
AC-SER-ASP-LYS-PRO-OH Chemical Properties,Uses,Production
Skin Benifits
AcSDKP is an oligopeptide composed of acetyl-Ser-Asp-Lys-Pro. Found at low concentrations endogenously,
AcSDKP is produced from thymosin and inhibits the phosphorylation of Smad2, therefore
downsizing the expression of genes regulated by TGFβ. This mechanism mediates an antifibrotic effect
and a reduction in edema. AcSDKP is catabolized almost exclusively by angiotensin converting enzyme
I (ACEI), although ACEI-resistant analogs have been created. AcSDKP has been recognized as a potent
inducer of angiogenesis and an anti-inflammatory agent, also contributing to its anti-fibrotic effects. Its
cutaneous anti-aging effects have also been investigated. AcSDKP at a concentration of 10−7–10−11
stimulates the expression of proteins that strengthen tight junctions, including caludin-1, occluding,
and ZO-1.
In an ex vivo study, topical AcSDKP accelerated skin healing after UV irradiation. AcSDKP
also stimulates the proliferation of keratinocytes, fibroblasts, and epidermal basal layer cells. Topical
application of 10−5 M AcSDKP also inhibits aging of human skin explants by significantly increasing
epidermal thickness after only six days, increases collagen III along the papillary dermis and collagen
IV along the basal membrane, with a concomitant increase in GAGs, especially HA. This peptide also
modulates the growth of human hair in an ex vivo study. Treatment of normal human dermal fibroblast
cells with AcSDKP showed increased collagen I synthesis and SIRTI, improving skin structure and
increasing cell longevity.78 In one study, topically administered AcSDKP on an ex vivo skin-explant
model significantly increases epidermis thickness after only six days of treatment with 10−8 M AcSKDP.
In addition to upregulating the expression of collagen and fibronectin along the dermo-epithelial junction,
AcSKDP also increases GAG deposited in the ECM, especially hyaluronic acid. Lastly, AcSDKP
encourages dermal fibroblasts and keratinocytes to proliferate and modulates hair growth.
Uses
N-Acetyl-Ser-Asp-Lys-Pro inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice. It is a specific substrate for the N-terminal active site of angiotensin converting enzyme, which is responsible for its degradation in vivo.
AC-SER-ASP-LYS-PRO-OH Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
Shanghai Yunao International Trade Co., Ltd | +8617621705551 | asdf@shanghaihg.cn | China | 265 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
zhuzhou dingcheng meihei comestic co.,ltd | +8618873369619 | dingchengbusiness8@163.com | China | 260 | 58 |
Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 | info@hyper-chem.com | China | 295 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 973 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 | mike@ge-tian.com | China | 269 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
View Lastest Price from AC-SER-ASP-LYS-PRO-OH manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-30 | Goralatide
127103-11-1
|
US $30.00 / box | 1box | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd | ||
2024-09-09 | Thymosin β4 (1-4)
127103-11-1
|
US $30.00 / Box | 1Box | 99.99% | 10000000000 | zhuzhou dingcheng meihei comestic co.,ltd | ||
2024-08-26 | Ac-Ser-Asp-Lys-Pro-OH
127103-11-1
|
US $0.00-0.00 / Gram | 1Gram | 98% | 1KG | Hangzhou Hyper Chemicals Limited |
- Goralatide
127103-11-1
- US $30.00 / box
- 98%
- hebei hongtan Biotechnology Co., Ltd
- Thymosin β4 (1-4)
127103-11-1
- US $30.00 / Box
- 99.99%
- zhuzhou dingcheng meihei comestic co.,ltd
- Ac-Ser-Asp-Lys-Pro-OH
127103-11-1
- US $0.00-0.00 / Gram
- 98%
- Hangzhou Hyper Chemicals Limited