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Vanillyl alcohol

CAS No.
498-00-0
Chemical Name:
Vanillyl alcohol
Synonyms
4-HYDROXY-3-METHOXYBENZYL ALCOHOL;Vanillin alcohol;Vanillinol;VANILLYL ALCOHOL(RG);4-Hydroxy-3-Methoxybenze-neMenthanol;4-HYDROXY-3-METHOXYBENZYL ALCOHOL (VANILLYL ALCOHOL);NSC 3993;vanillol;Vanillyl;FEMA 3737
CBNumber:
CB8709532
Molecular Formula:
C8H10O3
Molecular Weight:
154.16
MDL Number:
MFCD00004659
MOL File:
498-00-0.mol
MSDS File:
SDS
Last updated:2024-11-19 15:53:33

Vanillyl alcohol Properties

Melting point 110-117 °C (lit.)
Boiling point 237.52°C (rough estimate)
Density 1.1690 (rough estimate)
refractive index 1.4620 (estimate)
FEMA 3737 | VANILLYL ALCOHOL
storage temp. Inert atmosphere,Room Temperature
solubility soluble in Methanol
form Fine Crystalline Powder
pka 9.75±0.18(Predicted)
color Off-white to beige
Odor at 100.00 %. sweet creamy vanilla caramellic coconut graham cracker tonka milky powdery
Odor Type creamy
Water Solubility Soluble in 95% ethanol (5 %), water, and oils.
JECFA Number 886
BRN 1910044
Stability Stable. Incompatible with strong oxidizing agents, strong acids.
LogP 0.42
CAS DataBase Reference 498-00-0(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) VANILLYL ALCOHOL
EWG's Food Scores 1
FDA UNII X7EA1JUA6M
NIST Chemistry Reference 4-Hydroxy-3-methoxybenzyl alcohol(498-00-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
Hazard Note  Irritant
HS Code  29095090
NFPA 704
1
1 0

Vanillyl alcohol price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W373702 Vanillyl alcohol ≥98%, FG 498-00-0 100g $115 2024-03-01 Buy
Sigma-Aldrich W373702 Vanillyl alcohol ≥98%, FG 498-00-0 1kg $386 2024-03-01 Buy
Sigma-Aldrich 175536 4-Hydroxy-3-methoxybenzyl alcohol 98% 498-00-0 50g $66.8 2024-03-01 Buy
Sigma-Aldrich 175536 4-Hydroxy-3-methoxybenzyl alcohol 98% 498-00-0 250g $145 2024-03-01 Buy
TCI Chemical V0018 Vanillyl Alcohol >98.0%(GC) 498-00-0 25g $63 2024-03-01 Buy
Product number Packaging Price Buy
W373702 100g $115 Buy
W373702 1kg $386 Buy
175536 50g $66.8 Buy
175536 250g $145 Buy
V0018 25g $63 Buy

Vanillyl alcohol Chemical Properties,Uses,Production

Description

4-hydroxy-3-methoxybenzyl alcohol (also known as vanillyl alcohol) is often used as a deodorant component that is active in preventing the formation of body odor. It can also be used as a flavoring agent. Recent studies have also demonstrated that it has certain pharmacological effects. For example, it has been confirmed that it has certain neuro-protective effects through suppressing the oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells, making it a potential candidate for the treatment of neurodegenerative diseases such as Parkinson’s disease.

Chemical Properties

Vanillyl alcohol is a lignin derived aromatic diol. It has a mild, sweet, balsamic, vanilla-like odor.  It has a potential for the production of renewable epoxy thermosets. A bio-based bisphenolic analogue, bisguaiacol, was synthesized via the electrophilic aromatic condensation of vanillyl alcohol and guaiacol. From this, the diglycidyl ether of bisguaiacol was prepared. Further, three single aromatic diglycidyl ethers were synthesized from vanillyl alcohol, gastrodigenin, and hydroquinone. 

Chemical Properties

crystalline white to off-white powder

Uses

Used as a flavoring agent. Other possible uses, vanilla, coconut, cream and other dairy nuances, coumarin.

Definition

ChEBI: Vanillyl alcohol is a monomethoxybenzene that is 2-methoxyphenol substituted by a hydroxymethyl group at position 4. It has a role as a plant metabolite. It is a member of guaiacols and a member of benzyl alcohols.

Taste threshold values

Sweet, creamy and milky with a slightly powdery mouthfeel.

General Description

Vanillyl alcohol belongs to the phenolic group of compounds which are widely used as oxidants in food products.

Biochem/physiol Actions

Odor at 1.0%: sweet creamy, phenolic, vanilla and coconut-like with slight brown and coumarinic nuances.

Synthesis

Vanillyl alcohol is prepared from Vanillin by hydrogenation in presence of Platinum black.

References

Brune, I, et al. "Under the influence of the active deodorant ingredient 4-hydroxy-3-methoxybenzyl alcohol, the skin bacterium Corynebacterium jeikeium moderately responds with differential gene expression." Journal of Biotechnology 127.1(2006):21-33.
Hsu, Lun Chung, Z. H. Wen, and K. Y. Lee. "Use of vanillyl alcohol for the treatment of Parkinson's disease." (2009).
Kim, I. S., D. K. Choi, and H. J. Jung. "Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells." Molecules 16.7(2011):5349.

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View Lastest Price from Vanillyl alcohol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vanillyl Alcohol pictures 2024-11-19 Vanillyl Alcohol
498-00-0
US $46.00 / mL 97.02% 10g TargetMol Chemicals Inc.
Vanillyl alcohol pictures 2024-11-14 Vanillyl alcohol
498-00-0
US $0.00 / KG 1KG 99% 100 MT Hebei Weibang Biotechnology Co., Ltd
Vanillyl alcohol pictures 2024-10-25 Vanillyl alcohol
498-00-0
US $0.00 / KG 1KG 99% 500000kg Hebei Weibang Biotechnology Co., Ltd
3,4-Dihydroxybenzyl alcohol 3-Methyl ester α,4-Dihydroxy-3-Methoxytoluene 2-Hydroxy-5-(hydroxymethyl)anisole, 4-Hydroxy-3-methoxybenzyl alcohol, Vanillyl alcohol 4-Hydroxy-3-Methoxybenzyl alcohol, 99% 50GR 3-Methoxy-4-hydroxybenzyl alcohol Vanillic alcohol 4-HYDROXY-3-METHOXYBENZYL ALCOHOL, 98+% 4-Hydroxy-3-methoxybenzyl alcohol,99% Hydroxy-3-Methoxybenzyl alc 4-Hydroxy-3-Methoxybenzyl alcohol 98% NSC 3993 4-hydroxy-3-methoxy-benzenemethano 4-hydroxy-3-methoxybenzyl 4-hydroxy-3-methoxybenzylalcohol(vanillicalcohol) Benzenemethanol, 4-hydroxy-3-methoxy- vanillol RARECHEM AL BD 0101 VANILLYL ALCOHOL VANILLYL ALCOHOL MI VANILLYL ALCOHOL 98+% Vanillyl alcohol (4-Hydroxy-3-methoxybenzyl alcohol) Vanillyl FEMA 3737 A 4-DIHYDROXY-3-METHOXYTOLUENE CITRONELLOL, D-(SG) HOMOVANILLICALCOHOL 4-HYDROXY-3-METHOXYBENZENEMETHANOL 4-HYDROXYMETHYL-2-METHOXY-PHENOL Vanillin Impurity 3 4-Hydroxy-3-methoxybenzyl alcohol USP/EP/BP para-vanillyl alcohol 4-Hydroxy-3-Methoxybenzyl Alcohol CAS 498-00-0 C8h10o3 TIANFU-CHEM 498-00-0 4-Hydroxy-3-methoxybenzyl alcohol 4-Hydroxy-3-Methoxybenze-neMenthanol Vanillinol Vanillin alcohol 4-HYDROXY-3-METHOXYBENZYL ALCOHOL (VANILLYL ALCOHOL) VANILLYL ALCOHOL(RG) 4-HYDROXY-3-METHOXYBENZYL ALCOHOL HEXADECYL 2-ETHYLHEXANOATE 59130-69-7 Vanillyl alcohol (6CI, 8CI) Vanillyl Alcohol, ≥ 98.0% 498-00-0 4980-00-0 2560-07-7 HOC6H3CH2OHOCH3 HOC6H3OCH3CH2OH CH3OC6H3OHCH2OH ALCOHOL Oxygen Compounds Organic Building Blocks Building Blocks Alcohols C7 to C8 Inhibitors Bifunctional Linkers Linkers and Crosslinkers Alcohols