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Beraprost sodium

Beraprost sodium structure

CAS No.: 88475-69-8

Chemical Name:: Beraprost sodium

Synonyms: BERAPROST SODIUM SALT;Dorner;ML 1129;TRK 100;Berasus;Careload;PROCYLIN;Procyclin;MDL 201129;Befraprost

CBNumber:: CB8761736

Molecular Formula:: C24H29NaO5

Molecular Weight:: 420.47

MDL Number:: MFCD00911570

MOL File:: 88475-69-8.mol

MSDS File:: SDS

Last updated:2024-05-14 10:14:29

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Beraprost sodium Properties

Melting point	204-206°C
storage temp.	-20°C
solubility	DMF:77.0(Max Conc. mg/mL);183.12(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);47.56(Max Conc. mM) PBS (pH 7.2):19.0(Max Conc. mg/mL);45.19(Max Conc. mM)
form	powder
color	white to beige
InChIKey	YTCZZXIRLARSET-LIIFYGAANA-M
SMILES	[C@H]12[C@H](C[C@@H](O)[C@@H]1/C=C/[C@@H](O)C(C)CC#CC)OC1C(=CC=CC2=1)CCCC([O-])=O.[Na+] \|&1:0,1,3,5,8,r\|
CAS DataBase Reference	88475-69-8(CAS DataBase Reference)
FDA UNII	15K99VDU5F

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

NFPA 704

	0
4		0

Beraprost sodium price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1737	Beraprost sodium ≥98% (HPLC)	88475-69-8	1MG	$135	2023-06-20	Buy
Sigma-Aldrich	SML1737	Beraprost sodium ≥98% (HPLC)	88475-69-8	5MG	$542	2023-06-20	Buy
Cayman Chemical	18230	Beraprost (sodium salt) ≥98%	88475-69-8	1mg	$135	2024-03-01	Buy
Cayman Chemical	18230	Beraprost (sodium salt) ≥98%	88475-69-8	5mg	$540	2024-03-01	Buy
Cayman Chemical	18230	Beraprost (sodium salt) ≥98%	88475-69-8	10mg	$945	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1737	1MG	$135	Buy
SML1737	5MG	$542	Buy
18230	1mg	$135	Buy
18230	5mg	$540	Buy
18230	10mg	$945	Buy

Beraprost sodium Chemical Properties,Uses,Production

Description

Beraprost sodium is a new, orally active antithrombotic epoprostenol analog introduced as a treatment for peripheral vascular disease, including Raynaud's syndrome and Buerger's disease. The antiplatelet activity may be due to its elevation of cyclic AMP in platelets which is achieved by activating adenylate cyclase in the platelet membrane, followed by the inhibition ofCa⁺⁺- influx and thromboxane A2 formation.

Description

Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 μg in humans, given 1 to 3 times per day, have been demonstrated to improve clinical end points in diseases responsive to prostacyclin. Oral beraprost therapy improved the survival and pulmonary hemodynamics of patients with primary pulmonary hypertension. Beraprost inhibits platelet aggregation in healthy subjects and in diabetic patients at similar doses.

Chemical Properties

White Solid

Originator

Toray (Japan)

Uses

Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).

Definition

ChEBI: Beraprost sodium is the organic sodium salt of beraprost. It is used in the treatment of chronic arterial occlusive disease and primary pulmonary hypertension in Japan. It has a role as an antihypertensive agent, a platelet aggregation inhibitor, a prostaglandin receptor agonist, a vasodilator agent and an anti-inflammatory agent. It contains a beraprost(1-).

brand name

Dorner; Dorner;Procylin

General Description

Beraprost sodium is an orally active prostacyclin analog.

Biochem/physiol Actions

Beraprost sodium is used as a therapeutic agent for chronic artery obstructions or primary pulmonary hypertension. In individuals with coronary artery disease, beraprost sodium helps to reduce oxidative stress and developed forearm endothelium dependent vasodilation.

Side effects

Disease-related events had similar incidence in patients receiving beraprost and those receiving placebo. Drug-related adverse events like headache, flushing, jaw pain, and diarrhea were more common in patients treated with beraprost sodium and occurred mostly during the six-week titration period. The incidence was markedly reduced in the maintenance period. Six patients (9%) in the beraprost sodium group and two (3%) in the placebo group withdrew prematurely from the study because of adverse events. No clinically adverse changes in hematologic or biochemical variables were seen in the beraprost sodium group.

Beraprost sodium Preparation Products And Raw materials

Raw materials

Preparation Products

Beraprost sodium Suppliers

Global( 141)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Hope Pharmaceutical Co., Ltd.	+86-010-67886402 +8613611125266	market@hopelife.cn	China	72	58
Hebei Weimiao Import and Export Trade Co., Ltd.	+86-19948166995 +86-19948166995	sale01@hbweimiao.com	China	76	58
Shanghai Getian Industrial Co., LTD	+86-15373193816 +86-15373193816	mike@ge-tian.com	China	269	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9080	55
Shanghai finete Pharmaceutical Co., Ltd.	+86-18221039705		CHINA	139	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58

Supplier	Advantage
Beijing Hope Pharmaceutical Co., Ltd.	58
Hebei Weimiao Import and Export Trade Co., Ltd.	58
Shanghai Getian Industrial Co., LTD	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Shanghai finete Pharmaceutical Co., Ltd.	55
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from Beraprost sodium manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-13	Beraprost sodium 88475-69-8	US $0.00 / g	100mg	98.5%-101%	10G	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-27	Beraprost Sodium 88475-69-8	US $40.00-36.00 / kg	1kg	99%	200000	Hebei Weimiao Import and Export Trade Co., Ltd.
2024-05-15	Beraprost sodium 88475-69-8	US $21.00 / box	1box	99%	10000box	Shanghai Getian Industrial Co., LTD

Beraprost sodium
88475-69-8
US $0.00 / g
98.5%-101%
WUHAN FORTUNA CHEMICAL CO., LTD

Beraprost Sodium
88475-69-8
US $40.00-36.00 / kg
99%
Hebei Weimiao Import and Export Trade Co., Ltd.

Beraprost sodium
88475-69-8
US $21.00 / box
99%
Shanghai Getian Industrial Co., LTD

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1of4

beraprostsodium ML 1129 PROCYLIN TRK 100 2,3,3A-8B-TETRAHYDRO-2-HYDROXY-1-(3-HYDROXY-4-METHYL-1-OCTEN-6-YNYL)-1H-CYCLOPENTA[B]BENZOFURAN-5-BUTANOIC ACID, SODIUM SALT 1H-Cyclopenta[b]benzofuran-5-butanoic acid, 2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-, monosodium salt Dorner MDL 201129 dl-4-[(1R,2R,3aS,8bS)-2,3,3a,8b-Tetrahydro-2-hydroxy-[(3S,4RS)-3-hydroxy-4-Methyl-oct-6-yne-(E)-1-enyl]-5-cyclopenta[b]benzofuranyl]butanoic Acid SodiuM Berasus Careload Sodium 2,3,3a-8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta[b]benzofuran-5-butanoate Befraprost Unii-15K99vdu5f Beraprost sodium###Beraprost Procyclin 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-yn-1-yl)-1H-cyclopenta[b]benzofuran-5-butanoic acid sodium salt Beprostaglandin sodium sodium 4-[2-hydroxy-1-[(E)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl]butanoate Beraprost sodium USP/EP/BP BERAPROST SODIUM SALT Sodium (E)-4-(2-hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate (Beraprost Impurity) Sodium 4-(2-hydroxy-1-(3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-yl)butanoate sodium,4-[2-hydroxy-1-[(E)-3-hydroxy-4-methyloct-1-en-6-ynyl]-2,3,3a,8b-tetrahydro-1H-cyclopenta[b][1]benzofuran-5-yl]butanoate Beraprost sodium impurity 88475-69-8 C24H29O5Na C24H29NaO5 Prostaglandin Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Prostaglandins