Nafcillin sodium salt monohydrate
- CAS No.
- 7177-50-6
- Chemical Name:
- Nafcillin sodium salt monohydrate
- Synonyms
- nafcillin sodium;Nafcillin sodium hydrate;Nafcillin sodium monohydrate;D00928;CL 8491;Unipen (tn);Naproxillin sodium;Emorfazone Impurity 1;Nafcillin sodium (usp);NAFCILLINSODIUMSTERILE
- CBNumber:
- CB8769646
- Molecular Formula:
- C21H25N2NaO6S
- Molecular Weight:
- 456.49
- MDL Number:
- MFCD01941128
- MOL File:
- 7177-50-6.mol
- MSDS File:
- SDS
| storage temp. | 2-8°C |
|---|---|
| solubility | H2O: soluble50mg/mL |
| form | A crystalline solid |
| color | White to off-white |
| CAS DataBase Reference | 7177-50-6(CAS DataBase Reference) |
| FDA UNII | 49G3001BCK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H317-H319-H334-H335 | |||||||||
| Precautionary statements | P261-P280-P284-P304+P340-P305+P351+P338-P342+P311 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-42/43 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29411099 | |||||||||
| NFPA 704 |
|
Nafcillin sodium salt monohydrate price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N3269 | Nafcillin sodium salt monohydrate | 7177-50-6 | 5g | $191 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1450007 | Nafcillin sodium United States Pharmacopeia (USP) Reference Standard | 7177-50-6 | 200mg | $436 | 2024-03-01 | Buy |
| Cayman Chemical | 21008 | Nafcillin (sodium salt hydrate) ≥95% | 7177-50-6 | 1g | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 21008 | Nafcillin (sodium salt hydrate) ≥95% | 7177-50-6 | 5g | $152 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR1704 | Nafcillin Sodium Pharmaceutical Secondary Standard; Certified Reference Material | 7177-50-6 | 1g | $137 | 2022-05-15 | Buy |
Nafcillin sodium salt monohydrate Chemical Properties,Uses,Production
Originator
Unipen,Wyeth,US,1964
Uses
Sodium Nafcillin Monohydrate is used as an antibiotic, used in the treatment, used in the treatment of gram-positive bacteria.
Uses
Antibacterial;Bacterial transpeptidase inhibitor
Uses
Nafcillin sodium salt monohydrate is an antibiotic resistant to beta-lactamase.
Definition
ChEBI: Nafcillin sodium monohydrate is an organic sodium salt and a hydrate. It contains a nafcillin sodium.
Manufacturing Process
A stirred suspension of 12.6 grams 6-aminopenicillanic acid in 130 ml dry alcohol-free chloroform was treated with 16 ml triethylamine and then with 13.8 grams of a solution of 2-ethoxy-1-naphthoyl chloride in 95 ml chloroform. After being washed successively with 58 ml each of 1 N and then 0.1 N hydrochloric acid the chloroform solution was extracted with N aqueous sodium bicarbonate (58 ml + 6 ml). The combined bicarbonate extracts were washed with 20 ml ether and then evaporated at low temperature and pressure to give the crude sodium salt of 2-ethoxy-1-naphthylpenicillin [also called sodium 6-(2-ethoxy-1-naphthamido)penicillinate] as a yellow powder (20.3 grams). This was dissolved in 20 ml water at 30°C and diluted with 180 ml n-butanol, also at 30°C, with stirring. Slow cooling to 0°C gave colorless needles of the product.
brand name
Nallpen (GlaxoSmithKline).
Therapeutic Function
Antibacterial
Clinical Use
Nafcillin sodium, 6-(2-ethoxy-1-naphthyl)penicillin sodium(Unipen), is another semisynthetic penicillin that resultedfrom the search for penicillinase-resistant compounds. Likemethicillin, nafcillin has substituents in positions ortho tothe point of attachment of the aromatic ring to the carboxamidegroup of penicillin. No doubt, the ethoxy group andthe second ring of the naphthalene group play steric roles instabilizing nafcillin against penicillinase. Very similar structureshave been reported to produce similar results in somesubstituted 2-biphenylpenicillins.
Unlike methicillin, nafcillin is stable enough in acid topermit its use by oral administration. When it is givenorally, its absorption is somewhat slow and incomplete,but satisfactory plasma levels may be achieved in about1 hour. Relatively small amounts are excreted throughthe kidneys; most is excreted in the bile. Even thoughsome cyclic reabsorption from the gut may occur, nafcillingiven orally should be readministered every 4 to 6 hours.This salt is readily soluble in water and may be administeredintramuscularly or intravenously to obtain highplasma concentrations quickly for the treatment of seriousinfections.
Nafcillin sodium may be used in infections causedsolely by penicillin G-resistant staphylococci or whenstreptococci are present also. Although it is recommendedthat it be used exclusively for such resistant infections, nafcillin is also effective against pneumococci and groupA -hemolytic streptococci. Because, like other penicillins,it may cause allergic side effects, it should be administeredwith care.
Nafcillin sodium salt monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12809 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10244 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7859 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15393 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9691 | 58 |
View Lastest Price from Nafcillin sodium salt monohydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-27 | Nafcillin sodium monohydrate
7177-50-6
|
US $30.00 / mg | 96.62% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-03-21 | Nafcillin sodium salt monohydrate
7177-50-6
|
US $0.00 / Kg/Bag | 1KG | 99% | 20ton | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-03-06 | Nafcillin sodium salt monohydrate
7177-50-6
|
US $0.00 / kg | 1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- Nafcillin sodium monohydrate
7177-50-6
- US $30.00 / mg
- 96.62%
- TargetMol Chemicals Inc.
-
- Nafcillin sodium salt monohydrate
7177-50-6
- US $0.00 / Kg/Bag
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- Nafcillin sodium salt monohydrate
7177-50-6
- US $0.00 / kg
- 99%
- Shaanxi Dideu New Materials Co. Ltd