4-Pyrimidinecarboxamide, N-(cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]-
![4-Pyrimidinecarboxamide, N-(cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]- Structure](CAS/20200611/GIF/2393840-15-6.gif)
- CAS No.
- 2393840-15-6
- Chemical Name:
- 4-Pyrimidinecarboxamide, N-(cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]-
- Synonyms
- LEI-401;LEI401,LEI 401;4-Pyrimidinecarboxamide, N-(cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]-
- CBNumber:
- CB88096676
- Molecular Formula:
- C24H31N5O2
- Molecular Weight:
- 421.54
- MDL Number:
- MFCD32857148
- MOL File:
- 2393840-15-6.mol
4-Pyrimidinecarboxamide, N-(cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3125 | LEI-401 ≥98% (HPLC) | 2393840-15-6 | 5MG | $189 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3125 | LEI-401 ≥98% (HPLC) | 2393840-15-6 | 25MG | $756 | 2024-03-01 | Buy |
| Tocris | 7407 | LEI401 ≥98%(HPLC) | 2393840-15-6 | 10 | $219 | 2021-12-16 | Buy |
| ChemScene | CS-0130192 | LEI-401 99.93% | 2393840-15-6 | 5mg | $450 | 2021-12-16 | Buy |
| Axon Medchem | Axon3202 | LEI-401 99% | 2393840-15-6 | 25mg | $792 | 2021-12-16 | Buy |
4-Pyrimidinecarboxamide, N-(cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]- Chemical Properties,Uses,Production
Biological Activity
LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM. LEI-401 modulates emotional behavior in mice[1]. LEI-401 reduced a broad range of NAEs including anandamide in neuronal cells in a NAPE-PLD-dependent manner. LEI-401 (0.04-20 μM; 30 minutes) dose-dependently reduces the labeling of NAPE-PLD with an IC50 of 0.86 μM in hNAPE-PLD-transfected HEK293T cells. LEI-401 reduces NAE levels in Neuro-2a cells, but not in NAPE-PLD KO cells[1]. LEI-401 (30 mg/kg; i.p.) diminishes fear extinction in mice[1].LEI-401 also activates HPA axis signaling[1].LEI-401 (10 mg/kg; p.o.) treatment shows the t1/2, Cmax, tmax, AUClast, and F values of 2.5 hours, 1370 ng/mL, 2 hours, 6760 h*ng/mL, and 25%, respectively[1].LEI-401 (30 mg/kg; i.p.) treatment show the Cmax, tmax, AUClast, and F values of 10300 ng/mL, 1 hour, 38600 h*ng/mL, and 48%, respectively[1]. Animal Model: Male 7-12-week-old C57BL/6J mice[1]
storage
Store at -20°C
References
[1]. Mock ED, et al. Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice. Nat Chem Biol. 2020;16(6):667-675.
4-Pyrimidinecarboxamide, N-(cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
4-Pyrimidinecarboxamide, N-(cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11217 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1248 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9272 | 58 |
