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(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME

(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME structure

CAS No.: 667463-85-6

Chemical Name:: (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME

Synonyms: CS-1611;BIO-ACETOXIME;GSK-3 INHIBITOR X;GSK3 Inhibitor IX2;BIA|||GSK-3 Inhibitor X;BIO-acetoxime (Synonyms:);6-Bromoindirubin acetoxime;BIO-Acetoxime >=98% (HPLC);BIO-acetoxime, 10 mM in DMSO;6-Bromoindirubin-3′-acetoxime

CBNumber:: CB8818870

Molecular Formula:: C18H12BrN3O3

Molecular Weight:: 398.21

MDL Number:: MFCD09037533

MOL File:: 667463-85-6.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Properties

Density	1.69±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	H2O: soluble2mg/mL (clear solution, warmed)
form	powder
pka	9.22±0.20(Predicted)
color	dark red to purple
Water Solubility	H2O: 2mg/mL (clear solution, warmed)
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS09
Signal word	Warning
Hazard statements	H302-H410
Precautionary statements	P264-P270-P273-P301+P312-P391-P501
Hazard Codes	Xn,N
Risk Statements	22-50/53
Safety Statements	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3

(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0531	BIO-Acetoxime ≥98% (HPLC)	667463-85-6	5mg	$171	2024-03-01	Buy
Sigma-Aldrich	SML0531	BIO-Acetoxime ≥98% (HPLC)	667463-85-6	25mg	$656	2024-03-01	Buy
Tocris	3874	BIO-acetoxime ≥98%(HPLC)	667463-85-6	10	$308	2021-12-16	Buy
Tocris	3874	BIO-acetoxime ≥98%(HPLC)	667463-85-6	1	$148	2021-12-16	Buy
TRC	B591760	BIO-acetoxime	667463-85-6	1mg	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML0531	5mg	$171	Buy
SML0531	25mg	$656	Buy
3874	10	$308	Buy
3874	1	$148	Buy
B591760	1mg	$55	Buy

(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Chemical Properties,Uses,Production

Uses

BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. It also induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Biological Activity

Selective GSK-3 α / β inhibitor (IC 50 values are 0.01, 2.4, 4.3 and 63 μ M for GSK-3 α / β , CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

in vivo

BIO-acetoxime (BIA) shows anticonvulsant effects in the focal pilocarpine rat model at 0.5 mg/kg, and in 6-Hz fully kindled FVB/N mice at 0.5, 2.5, and 5 mg/kg via i.p. administration^[3].

IC 50

HSV-1; GSK-3α: 10 nM (IC₅₀); GSK-3β: 10 nM (IC₅₀); CDK5/p35: 2.4 μM (IC₅₀); CDK2/cyclin A: 4.3 μM (IC₅₀); CDK1/cyclin B: 63 μM (IC₅₀)

storage

Store at +4°C

(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Preparation Products And Raw materials

Raw materials

Preparation Products

(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Suppliers

Global( 116)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29808	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38630	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58

View Lastest Price from (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-05	(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME 667463-85-6	US $1.00 / KG	1KG	95--99%	1ton	Career Henan Chemical Co

(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME
667463-85-6
US $1.00 / KG
95--99%
Career Henan Chemical Co

(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Spectrum

(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME(667463-85-6)¹HNMR

(2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME BIO-ACETOXIME GSK-3 INHIBITOR X (3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one 6-Bromoindirubin acetoxime 6-Bromoindirubin-3′-acetoxime GSK3 Inhibitor IX2 BIO-acetoxime(GSK-3 Inhibitor) (2Z,3E)-3-(Acetoxyimino)-6'-bromo-[2,3'-biindolinylidene]-2'-one BIO-acetoxime GSK3 Inhibitor IX2 CS-1611 GSK3 INHIBITOR X6-BROMOINDIRUBIN-3'-ACETOXIME BIO-acetoxime (GSK-3 Inhibitor X) 2H-Indol-2-one, 3-[(3E)-3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-, (3Z)- BIO-Acetoxime >=98% (HPLC) BIA|||GSK-3 Inhibitor X BIO-acetoxime, GSK-3alpha/beta inhibitor BIO-acetoxime, 10 mM in DMSO BIO-acetoxime (Synonyms:) 667463-85-6 Other enzyme inhibitors and activators