INDEX NAME NOT YET ASSIGNED
- CAS No.
- 2292123-03-4
- Chemical Name:
- INDEX NAME NOT YET ASSIGNED
- Synonyms
- (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-((R)-5-(benzyloxy)-5-oxopentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triyl tris(2-((S)-2-amino-3-methylbutanamido)acetate)
- CBNumber:
- CB88365435
- Molecular Formula:
- C52H82N6O11
- Molecular Weight:
- 967.26
- MDL Number:
- MOL File:
- 2292123-03-4.mol
INDEX NAME NOT YET ASSIGNED price
INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production
Description
CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity. It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively). CAP 3 increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro. It reduces the biomass and number of colony-forming units in E. coli biofilms in a concentration-dependent manner. CAP 3 inhibits E. coli biofilm formation on catheters implanted in mice infected with E. coli at the incision site when applied as a coating on the catheters. CAP 3 (40 mg/kg) also reduces bacterial load in E. coli-infected wounds in mice. It is cytotoxic to A459 cells (IC50 = 56.4 μM) and has hemolytic activity against human red blood cells with a 50% lysis (HC50) value of 48 μM.
INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials
Raw materials
Preparation Products
INDEX NAME NOT YET ASSIGNED Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11975 | 58 |
Supplier | Advantage |
---|---|
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 58 |