Suplatast tosilate
- CAS No.
- 94055-76-2
- Chemical Name:
- Suplatast tosilate
- Synonyms
- Suplatast tosylate;IPD-1151T;Suplatast;SUPLATAST TOSILATE;Suplatast Tosylate >Methotrexate Impurity 47;Suplatast tosilate USP/EP/BP;Suplatast Tosylate (IPD 1151T);TIANFU CHEM--Suplatast tosilate;N,N-dimethyl-2-propyl-1-pentanamine
- CBNumber:
- CB8837187
- Molecular Formula:
- C23H33NO7S2
- Molecular Weight:
- 499.64062
- MDL Number:
- MFCD00867604
- MOL File:
- 94055-76-2.mol
- MSDS File:
- SDS
| Melting point | 84-87°C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO: >20mg/mL |
| form | powder |
| color | white to off-white |
| Merck | 14,9003 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 94055-76-2(CAS DataBase Reference) |
| FDA UNII | C9J89787U1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
| RTECS | WR7906000 |
| HS Code | 2930.90.2900 |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 81, 96, 96, 93 i.v.; in mice, rats (g/kg): >12.5, >10 orally (Yamashita) |
Suplatast tosilate price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S4701 | Suplatast tosylate ≥98% (HPLC) | 94055-76-2 | 50mg | $347 | 2024-03-01 | Buy |
| Sigma-Aldrich | S4701 | Suplatast tosylate ≥98% (HPLC) | 94055-76-2 | 10mg | $77.6 | 2022-05-15 | Buy |
| TCI Chemical | S0875 | Suplatast Tosylate >98.0%(HPLC)(N) | 94055-76-2 | 100mg | $51 | 2024-03-01 | Buy |
| TCI Chemical | S0875 | Suplatast Tosylate >98.0%(HPLC)(N) | 94055-76-2 | 1g | $303 | 2024-03-01 | Buy |
| Cayman Chemical | 30316 | Suplatast (tosylate) | 94055-76-2 | 50mg | $68 | 2024-03-01 | Buy |
Suplatast tosilate Chemical Properties,Uses,Production
Description
Suplatast tosylate is a unique dimethylsulfonium salt marketed in Japan for the treatment of bronchial asthma, atopic dermatitis and allergic rhinitis. Suplatast tosylate is a potent inhibitor of IgE synthesis without suppressing IgM and IgG. The mechanism of action for suplatast tosylate is thought to be via the inhibition of interleukin-4 and interleukin-6 production by T-cells at the gene level. In allergic patients, suplatast tosylate markedly improved clinical symptoms which correlated with a significant decrease in serum IgE antibody levels.
Description
Suplatast is an antiallergic agent. It inhibits IL-4 and IL-5 production in conalbumin-stimulated D10.G4.1 murine T helper 2 (Th2) cells in a concentration-dependent manner. Suplatast (100 mg/kg) inhibits ovalbumin-induced increases in eosinophil and total cell numbers, as well as IL-4, IL-5, and IL-13, but not IFN-γ, levels in bronchoalveolar lavage fluid (BALF) in an ovalbumin-sensitized mouse model of asthma. It also inhibits ovalbumin-induced increases in ovalbumin-specific IgE in serum and bronchial hyperresponsiveness to methacholine in the ovalbumin-sensitized mouse model of asthma.
Originator
Taiho (Japan)
Uses
Suplatast Tosylate is an antiallergic drug. Suplatast Tosylate inhibits antigen-induced histamine release from mast cells as well as IgE antibody formation. Suplatast Tosylate suppresses interleukin (IL)-4 release from T cells, however in human peripheral basophils, Suplatast Tosylate inhibited the antigen-induced release of IL-13 but not IL-4.
Uses
Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.
brand name
IPD
Biological Activity
Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN- γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.
References
1) Kurokawa?et al.?(2001),?Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo; Mediators Inflamm.,?10?333 2) Hsu?et al.?(2007),?The effects of suplatast tosilate (IPD-1151T) on innate immunity and antigen-presenting cells; Transpl. Immunol.,?18?108 3) Furonaka?et al.?(2009),?Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice; Curr. Opin. J. Pharmacol. Exp. Ther.,?328?55 4) Bhattachrya?et al.?(2014),?Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy against tuberculosis; J. Biol. Chem.,?289?33404 5) Wada?et al.?(2009),?Effect of suplatast tosilate on antileukotriene non-responders with mild-to-moderate persistent asthma; Allergol. Int.,?58?389
Suplatast tosilate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12840 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 7514 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18154 | 58 |
| Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 | sales8@hbganmiao.com | China | 299 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14394 | 58 |
View Lastest Price from Suplatast tosilate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Suplatast (Tosilate)
94055-76-2
|
US $63.00-39.00 / mg | 99.34% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Suplatast (Tosilate)
94055-76-2
|
US $63.00-39.00 / mg | 99.34% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-01 | Suplatast tosilate
94055-76-2
|
US $65.40-800.00 / g | 1g | 0.98 | 10kg | Shanghai UCHEM Inc. |
-
- Suplatast (Tosilate)
94055-76-2
- US $63.00-39.00 / mg
- 99.34%
- TargetMol Chemicals Inc.
-
- Suplatast (Tosilate)
94055-76-2
- US $63.00-39.00 / mg
- 99.34%
- TargetMol Chemicals Inc.
-
- Suplatast tosilate
94055-76-2
- US $65.40-800.00 / g
- 0.98
- Shanghai UCHEM Inc.