FALECALCITRIOL
- CAS No.
- 83805-11-2
- Chemical Name:
- FALECALCITRIOL
- Synonyms
- Hornel;ST 630;Fulstan;Ro 23-4194;Flocalcitrol;Flocacitriol;Falecalcitol;Flocalcitriol;F6-1,25(OH)2D3;FALECALCITRIOL
- CBNumber:
- CB8849801
- Molecular Formula:
- C27H38F6O3
- Molecular Weight:
- 524.58
- MDL Number:
- MFCD00870595
- MOL File:
- 83805-11-2.mol
- MSDS File:
- SDS
Boiling point | 576.9±50.0 °C(Predicted) |
---|---|
Density | 1.24±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C,unstable in solution, ready to use. |
solubility | Soluble in DMSO |
form | Powder |
pka | 9.77±0.29(Predicted) |
color | White to off-white |
FDA UNII | G70A8514T8 |
FALECALCITRIOL price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | F101110 | Falecalcitriol | 83805-11-2 | 10mg | $11000 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0002674 | FALECALCITRIOL 95.00% | 83805-11-2 | 10MG | $12127.5 | 2021-12-16 | Buy |
ChemScene | CS-0801 | Falecalcitriol 95.09% | 83805-11-2 | 1mg | $1056 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0002674 | FALECALCITRIOL 95.00% | 83805-11-2 | 1MG | $1424.85 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 17932 | Falecalcitriol | 83805-11-2 | 1mg | $1790 | 2021-12-16 | Buy |
FALECALCITRIOL Chemical Properties,Uses,Production
Description
Falecalcitriol, previously known as flocalcitrol, was launched by several codevelopers in Japan for the treatment of secondary hyperthyroidism (SHPT). This hexafluorinated analog of 1α,25-dihydroxyvitamin D3 (calcitriol), the hormonally active form of vitamin D3, can be obtained by several different synthetic routes from a conveniently protected cholestenol, a key step being an aldol reaction with hexafluoroacetone. Falecalcitriol is several times more active than 1,25(OH)2D3 in regulating the proliferation of parathyroid cells and parathyroid hormone (PTH) synthesis that are believed to be mediated through binding to VDR, a nuclear receptor for vitamin D; furthermore, it was proposed that a bioactive 23S-hydroxylated metabolite, resistant to further metabolism, contributes to the retention of an active compound for longer in cells and so, to significantly lengthen the duration of action. In a comparative clinical study conducted in hemodialysis patients with moderate to severe SHPT, falecalcitriol was found to be more active than alfacalcidol in suppressing parathyroid hormone without triggering hypercalcemia.
Originator
University of Wisconsin (US)
Uses
Hexafluorinated analog of Calcitriol (C144500). A more potent therapeutic agent for secondary hyperparathyroidism.
brand name
Hornel, Fulstan
Hazard
A poison by ingestion.
FALECALCITRIOL Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
ChemExpress | +86-021-58950125 +86-021-58950125; | info@chemexpress.com | China | 781 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
View Lastest Price from FALECALCITRIOL manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-10-28 | Falecalcitriol
83805-11-2
|
US $3980.00-5500.00 / mg | 10g | TargetMol Chemicals Inc. | ||||
2020-02-19 | FALECALCITRIOL
83805-11-2
|
US $7.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
- Falecalcitriol
83805-11-2
- US $3980.00-5500.00 / mg
- TargetMol Chemicals Inc.
- FALECALCITRIOL
83805-11-2
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
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