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4'-Hydroxypropiophenone

4'-Hydroxypropiophenone structure

CAS No.: 70-70-2

Chemical Name:: 4'-Hydroxypropiophenone

Synonyms: PHP;b360;B 360;H-365;Mepal;Frenon;Paroxon;VANATONE;Bio-Fren;Hypostat

CBNumber:: CB8854142

Molecular Formula:: C9H10O2

Molecular Weight:: 150.17

MDL Number:: MFCD00008745

MOL File:: 70-70-2.mol

MSDS File:: SDS

Last updated:2025-03-15 17:35:32

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4'-Hydroxypropiophenone Properties

Melting point	36-38 °C(lit.)
Boiling point	152-154 °C26 mm Hg(lit.)
bulk density	300-400kg/m3
Density	1.09 g/cm3 (20℃)
refractive index	1.5360 (estimate)
FEMA	2005 \| ACETANISOLE
Flash point	>230 °F
storage temp.	Store below +30°C.
solubility	methanol: 0.1 g/mL, clear
form	Solid
pka	8.87±0.26(Predicted)
color	White
Water Solubility	0.34 g/l (15 ºC)
Merck	14,7044
BRN	907511
LogP	2.030
CAS DataBase Reference	70-70-2(CAS DataBase Reference)
EWG's Food Scores	1
NCI Dictionary of Cancer Terms	PHP
FDA UNII	X9952001TG
NIST Chemistry Reference	1-Propanone, 1-(4-hydroxyphenyl)-(70-70-2)
EPA Substance Registry System	1-Propanone, 1-(4-hydroxyphenyl)- (70-70-2)
UNSPSC Code	12352115
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Xn,Xi

Risk Statements

36/37/38

Safety Statements

37-24/25-36-26

WGK Germany

RTECS

UH1925000

TSCA

Yes

HS Code

29145000

Toxicity

LD50 orally in Rabbit: 11800 mg/kg

NFPA 704

	1
2		0

4'-Hydroxypropiophenone price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H55405	4′-Hydroxypropiophenone 98%	70-70-2	100g	$39.96	2024-03-01	Buy
Sigma-Aldrich	8.20692	4′-Hydroxypropiophenone for synthesis	70-70-2	100g	$70.4	2024-03-01	Buy
TCI Chemical	H0299	4'-Hydroxypropiophenone >98.0%(GC)	70-70-2	25g	$28	2024-03-01	Buy
TCI Chemical	H0299	4'-Hydroxypropiophenone >98.0%(GC)	70-70-2	500g	$161	2024-03-01	Buy
Alfa Aesar	A15314	4'-Hydroxypropiophenone, 99%	70-70-2	100g	$41.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
H55405	100g	$39.96	Buy
8.20692	100g	$70.4	Buy
H0299	25g	$28	Buy
H0299	500g	$161	Buy
A15314	100g	$41.65	Buy

4'-Hydroxypropiophenone Chemical Properties,Uses,Production

Chemical Properties

white powder

Uses

p-Hydroxypropiophenone is a 4-hydroxyphenyl ketone used in the preparation of potential antitumor agents. p-Hydroxypropiophenone is a lignin degrradation product.

Uses

Intermediates of Liquid Crystals

Uses

gonadotropic hormone inhibitor

Preparation

Preparation by Fries rearrangement of phenyl propionate
with aluminium chloride in refluxing carbon disulfide ? then at 130–150° for 2–3 h after solvent elimination (45–50%)
with aluminium chloride in nitrobenzene at 50° for 18 h (72%) or at ? 20° for 48 h (60%)
with aluminium chloride in nitromethane at 20° for 7–8 days (80%)
with aluminium chloride in chlorobenzene using microwave irradiation for ? 3 min at 106° (62%)
with aluminium chloride in ethylene dichloride at 95° for 5 h or in heptane at ? 80–90° for 7 h (36%), in benzene or in tetrachloroethane at 80°; with aluminium chloride in the presence of propionyl chloride at 50–60° for ? 6 h (49%)
with aluminium chloride without solvent at 50° for 10 h
with titanium tetrachloride in nitromethane at 20° for 7 days (56%) or ? without solvent at 50° for 10 h (39%)
with polyphosphoric acid at 100° (61%)
with boron trifluoride at 50° for 3 h (46%)
with stannic chloride at 50° for 3 h (10%).

Definition

ChEBI: P-Hydroxypropiophenone is a member of acetophenones.

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 2491, 1965 DOI: 10.1021/jo01018a528

Safety Profile

Poison by intraperitoneal, subcutaneous, and parenteral routes. An experimental teratogen. Other experimental reproductive effects. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

target

Estrogen receptor

Purification Methods

4'-Hydroxypropiophenone [70-70-2] M 150.2, m 149o, b 140-145o/0.5mm, 8.05. Crystallise the phenone from H2O (m 149.8-150.2o) or EtOH (m 147o). The benzoyl derivative has m 117o, and the semicarbazone has m 183o (EtOH). [Beilstein 8 H 102, 8 II 104, 8 III 379.]

4'-Hydroxypropiophenone synthesis

Synthesis of 4'-Hydroxypropiophenone from Propionyl chloride and Phenol

4'-Hydroxypropiophenone Preparation Products And Raw materials

Raw materials

Carbon disulfide phenyl propionate Methoxypropiophenone Benzenemethanol, α-ethyl-4-hydroxy- 4-BENZYLOXYPROPIOPHENONE

4'-Bromopropiophenone 4-Propylphenol

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Preparation Products

2'-Hydroxypropiophenone 4-Propanoylphenyl 2,2-dimethylpropanoate 4-(4-hydroxyphenyl)-5-methyl-1,3-hiazol-2-amine 1-(3,5-Dibromo-4-hydroxyphenyl)-1-propanone 1-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]PROPAN-1-ONE

(E/Z)-1-[4-(2-Chloroethoxy)phenyl]-2-(4-hydroxyphenyl)-1-phenyl-1-butene 1-[4-(difluoromethoxy)phenyl]propan-1-amine

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4'-Hydroxypropiophenone Suppliers

Global( 568)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2176	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-15531157085 +86-15531157085	abby@chuanghaibio.com	China	8806	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3882	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12819	58
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	Ethan@dornechem.com	China	3091	58
Shanghai Likang New Materials Co., Limited	+86-16631818819 +86-17736933208	3684455296@qq.com	China	9300	58
Hebei Yiduo Import and Export Co., Ltd.		joycedemei1505@outlook.com	China	205	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	info@dakenam.com	China	19825	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21631	55

Supplier	Advantage
Changzhou Ditong Chemical Co.,Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Dorne Chemical Technology co. LTD	58
Shanghai Likang New Materials Co., Limited	58
Hebei Yiduo Import and Export Co., Ltd.	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from 4'-Hydroxypropiophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-03-27	4'-Hydroxypropiophenone 70-70-2	US $10.00 / ASSAYS	1ASSAYS	99%	10 ton	Dorne Chemical Technology co. LTD
2025-03-27	4'-Hydroxypropiophenone 70-70-2	US $10.00 / kg	1kg	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-03-21	4'-Hydroxypropiophenone 70-70-2	US $100.00 / KG	1KG	99%	5000KG	Hebei Mujin Biotechnology Co.,Ltd

4'-Hydroxypropiophenone
70-70-2
US $10.00 / ASSAYS
99%
Dorne Chemical Technology co. LTD

4'-Hydroxypropiophenone
70-70-2
US $10.00 / kg
99%
Hebei Chuanghai Biotechnology Co., Ltd

4'-Hydroxypropiophenone
70-70-2
US $100.00 / KG
99%
Hebei Mujin Biotechnology Co.,Ltd

4'-Hydroxypropiophenone Spectrum

4'-Hydroxypropiophenone(70-70-2)¹HNMR 4'-Hydroxypropiophenone(70-70-2)IR1 4'-Hydroxypropiophenone(70-70-2)Raman

70-70-2(4'-Hydroxypropiophenone)Related Search:

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4-Hydroxyphenethyl alcohol Sodium 4-hydroxybenzenesulfonate 4-Hydroxyphenylacetic acid Tyramine 4-CHLORO-4'-HYDROXYBUTYROPHENONE

Methyl 4-hydroxyphenylacetate 4-Hydroxybenzyl alcohol 4-Hydroxyphenylpyruvic acid Para Methoxy Acetophenone

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PARA-ETHYLKETOPHENOL PARA-PROPIONYLPHENOL 4-HYDROXYPROPIOPHENONE / PAROXYPROPIONE 1-(4-hydroxyphenyl)propan-1-one 4''-HYDROXYPROPRIOPHENONE 4′-Hydroxypropiophen P-acetone 4'-Hydroxypropiophenone, 97+% 4'-Hydroxypropiophenone≥ 99.0% (HPLC) P-HYDROXYPROPIOPHENONE P-HYDROXYL PROPIOPHENONE P-METHOXYACETOPHENONE PAROXYPROPIONE PARA METHOXY ACETOPHENONE VANATONE 1-(4-hydroxyphenyl)-1-propanon 1-(4-Hydroxyphenyl)-1-propanone 1-(p-Hydroxyphenyl)-1-Propanone 4’-hydroxy-propiophenon LABOTEST-BB LT00855519 LABOTEST-BB LT01595901 ETHYL 4-HYDROXYPHENYL KETONE FEMA 2005 AURORA 5371 p-Methylbenzoic Acid Methyl Ether ACETANISOLE AKOS 90580 AKOS BBS-00003225 AKOS BBS-00003216 4-METHOXYPHENYLETHANONE 4-HYDROXYPHENYL ETHYL KETONE 4-HYDROXYPROPIOPHENONE 4-ACETOANISOLE 4-ACETYLANISOLE (4-Hydroxyphenyl)-1-propanone 4'-HYDROXY PROPIOPHENONE P-HYDROXYPHENYLETHYLKETONE 4-HydoxyPropiophenone 4'-Hydroxypropiophenone, 98+% P-Hydroxyl 1-Propanone, 1-(4-hydroxyphenyl)- P-HYDROXYPHENYLETHYLKETONE 1-(4-METHOXYPHENYL)ETHANONE hydrolytic polyacrylamide 4-Hydroxypropiophenon 4-Propanoylphenol 4-Propionylphenol B 360 b360 Bio-Fren Ethyl p-hydroxyphenyl ketone ethylp-hydroxyphenylketone Frenantol Frenohypon Frenon Frenormon H-365 Hydroxypropiophenone Hypophenon