N-phenyl-1,3,5-triazine-2,4-diaminemonohydrochloride

Originator

Amanozine,Onbio Inc.

Manufacturing Process

21.3 g (0.1 mole) of 1-phenylbiguanide hydrochloride were dissolved in hot water and the solution was added to 5.3 g (0.05 mole) sodium carbonate by stirring. On cooling 15 g of the needle crystals have fallen. They were heated to reflux with 80 ml of dry formic acid. Then 40-50 ml formic acid was distilled off. The residue was with water diluted, cooled with ice and the conc. alkali was added. The precipitate fallen. It was filtered off and recrystallized from 40-50% ethanol. The pure product 4-amino-2-anilino-1,3,5-triazine had MP: 232°-233°C.
Monochlorohydrate of it crystallized as long colorless needles melted at 258°- 260°C.

Therapeutic Function

Diuretic

Raw materials

Preparation Products