ChemicalBook >> CAS DataBase List >>4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-

4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-

4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]- structure

CAS No.: 1159408-64-6

Chemical Name:: 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-

Synonyms: ZGN-002;Tri-GalNAc(OAc)3;(2R,3R,4R,5R,6R)-3,4-bis(acetyloxy)-6-{4-[(3-{3-[2-amino-3-(2-{[3-(5-{[(2R,3R,4R,5R,6R)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]-3-acetamidooxan-2-yl]oxy}pentanamido)propyl]carbamoyl}ethoxy)-2-[(2-{[3-(5-{[(2R,3R,4R,5R,6R)-4,5-bis(acetyloxy)-6-[(acetylox;4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl...;4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-;6-[4-[N-[3-[3-[3-[2-[N-[3-[5-[(5R,2R,3R,4R,6R)-3-(Acetylamino)-4,5-diacetyloxy-6-(acetyloxymethyl)(2H-3,4,5,6-tetrahydropyran-2-yloxy)]pentanoylamino]propyl]carbamoyl]ethoxy]-2-[[2-[N-[3-[5-[(5R,2R,3R,4R,6R)-3-(acetylamino)-4,5-diacetyloxy-6-(acetyloxymethyl)(2H-3,4,5,6-tetrahydropyran-2-yloxy)]pentanoylamino]propyl]carbamoyl]ethoxy]methyl]-2-aminopropoxy]propanoylamino]propyl]carbamoyl]butoxy](3R;6-[4-[N-[3-[3-[3-[2-[N-[3-[5-[(5R,2R,3R,4R,6R)-3-(Acetylamino)-4,5-diacetyloxy-6-(acetyloxymethyl)(2H-3,4,5,6-tetrahydropyran-2-yloxy)]pentanoylamino]propyl]carbamoyl]ethoxy]-2-[[2-[N-[3-[5-[(5R,2R,3R,4R,6R)-3-(acetylamino)-4,5-diacetyloxy-6-(acetyloxymethyl)(2H-3,4,5,6-tetrahydropyran-2-yloxy)]pentanoylamino]propyl]carbamoyl]ethoxy]methyl]-2-aminopropoxy]propanoylamino]propyl]carbamoyl]butoxy](3R,2R,4R,5R,6R)-5-(acetylamino)-4-acetyloxy-2-(acetyloxymethyl)-2H-3,4,5,6-tetrahydropyran-3-yl Acetat

CBNumber:: CB89017977

Molecular Formula:: C79H128N10O36

Molecular Weight:: 1793.93

MDL Number:

MOL File:: 1159408-64-6.mol

Last updated:2024-07-02 08:55:39

Request For Quotation

4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]- Properties

Boiling point	1585.5±65.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
pka	13.13±0.70(Predicted)
form	Solid
color	White to off-white

4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]- Chemical Properties,Uses,Production

Description

VPN08646 is a triantenerrary N-acetylgalactosamine (tri-GalNAc) with an amino group, which is useful precursor for synthesis of GalNAc-LYTAC that engage the asialoglycoprotein receptor for targeted protein degradation. VPN08646 was first reported in Nat Chem Biol. 2021 Sep;17(9):937-946 (compound ). This product has no formal name at the moment.

4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]- Suppliers

Global( 12)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changsha Morning Shine Co., Ltd.	13397510867	dingningjing@csmspharm.com	China	190	58
Wuhu Huaren Science and Technology Co., Ltd.	0553-0553-5842013-801 18155347026	jinhuaren@huarensh.com	China	715	58
Chengdu Zen Sunda Bio-pharmaceutical Technology Co., Ltd.	19981275275	sales@zsdbiopharm.com	China	285	58
Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd.	13414494621	chenchao02lzu@126.com	China	114	58
Henan Pumei Jihua Pharmaceutical Technology Co., Ltd.	037188900765 18037465274	enyawanglei@sina.cn	China	13625	58
Shanghai fuxiang biotechnology co., ltd	13611719524	2674347328@qq.com	China	49	58
LinkChem Co.,Ltd.	21-21-20222982 13124863828	sales@linkchem.cn	China	2974	58
Kuang Bo Technology (Tianjin) Co. , Ltd.	16600677255; 16600677255	kuangbotec@163.com	China	334	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 18112977050	cb5@aikonchem.com	China	10529	58
Shanghai Inchman Chemical Technology Co., LTD	18299177127 18299177127	info@richmanchem.com	China	3000	58

Supplier	Advantage
Changsha Morning Shine Co., Ltd.	58
Wuhu Huaren Science and Technology Co., Ltd.	58
Chengdu Zen Sunda Bio-pharmaceutical Technology Co., Ltd.	58
Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd.	58
Henan Pumei Jihua Pharmaceutical Technology Co., Ltd.	58
Shanghai fuxiang biotechnology co., ltd	58
LinkChem Co.,Ltd.	58
Kuang Bo Technology (Tianjin) Co. , Ltd.	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	58
Shanghai Inchman Chemical Technology Co., LTD	58

(2R,3R,4R,5R,6R)-3,4-bis(acetyloxy)-6-{4-[(3-{3-[2-amino-3-(2-{[3-(5-{[(2R,3R,4R,5R,6R)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]-3-acetamidooxan-2-yl]oxy}pentanamido)propyl]carbamoyl}ethoxy)-2-[(2-{[3-(5-{[(2R,3R,4R,5R,6R)-4,5-bis(acetyloxy)-6-[(acetylox 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]- Tri-GalNAc(OAc)3 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl... 6-[4-[N-[3-[3-[3-[2-[N-[3-[5-[(5R,2R,3R,4R,6R)-3-(Acetylamino)-4,5-diacetyloxy-6-(acetyloxymethyl)(2H-3,4,5,6-tetrahydropyran-2-yloxy)]pentanoylamino]propyl]carbamoyl]ethoxy]-2-[[2-[N-[3-[5-[(5R,2R,3R,4R,6R)-3-(acetylamino)-4,5-diacetyloxy-6-(acetyloxymethyl)(2H-3,4,5,6-tetrahydropyran-2-yloxy)]pentanoylamino]propyl]carbamoyl]ethoxy]methyl]-2-aminopropoxy]propanoylamino]propyl]carbamoyl]butoxy](3R,2R,4R,5R,6R)-5-(acetylamino)-4-acetyloxy-2-(acetyloxymethyl)-2H-3,4,5,6-tetrahydropyran-3-yl Acetat ZGN-002 6-[4-[N-[3-[3-[3-[2-[N-[3-[5-[(5R,2R,3R,4R,6R)-3-(Acetylamino)-4,5-diacetyloxy-6-(acetyloxymethyl)(2H-3,4,5,6-tetrahydropyran-2-yloxy)]pentanoylamino]propyl]carbamoyl]ethoxy]-2-[[2-[N-[3-[5-[(5R,2R,3R,4R,6R)-3-(acetylamino)-4,5-diacetyloxy-6-(acetyloxymethyl)(2H-3,4,5,6-tetrahydropyran-2-yloxy)]pentanoylamino]propyl]carbamoyl]ethoxy]methyl]-2-aminopropoxy]propanoylamino]propyl]carbamoyl]butoxy](3R 1159408-64-6 C79H128N10O36 GalNAc