ChemicalBook >> CAS DataBase List >>2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
- CAS No.
- 53995-62-3
- Chemical Name:
- 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
- Synonyms
- PFI-90;N'-(Pyridin-2-yl)picolinohydrazide;N'-(Pyridin-2-yl)picolinohydrazide;N'-pyridin-2-ylpyridine-2-carbohydrazide;2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide;antitumor,Inhibitor,PFI 90,differentiation,PAX3-FOXO1,demethylase,PFI-90,apoptosis,histone,Histone Demethylase,myogenic,PFI90,inhibit
- CBNumber:
- CB89028245
- Molecular Formula:
- C11H10N4O
- Molecular Weight:
- 214.22
- MDL Number:
- MFCD27925103
- MOL File:
- 53995-62-3.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:39
2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Chemical Properties,Uses,Production
Biological Activity
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1). PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1]. PFI-90 (3 μμ; 24 hours) increases apoptosis in RH4 and SCMC cells[1].
References
[1]. KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.
Synthesis of 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide from 2-Picolinic acid and 2-Hydrazinopyridine
2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Suppliers
Global( 39)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4694 | 58 |
| Compound Net Biotechnology Inc. | +8615303909093 | sales@compound-net.com | China | 2914 | 58 |
| Gihi Chemicals Co., Limited | +86-0571-86217390 +8618058761490 | info@gihichem.com | China | 998 | 58 |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 1000 | 55 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3732 | 55 |
View Lastest Price from 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-06-10 | 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
53995-62-3
|
US $10.00 / kg | 0.1kg | 98% | 1000kg | Gihi Chemicals Co., Limited |
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- 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
53995-62-3
- US $10.00 / kg
- 98%
- Gihi Chemicals Co., Limited
2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
PFI-90
N'-(Pyridin-2-yl)picolinohydrazide
antitumor,Inhibitor,PFI 90,differentiation,PAX3-FOXO1,demethylase,PFI-90,apoptosis,histone,Histone Demethylase,myogenic,PFI90,inhibit
N'-(Pyridin-2-yl)picolinohydrazide
N'-pyridin-2-ylpyridine-2-carbohydrazide
53995-62-3