GSK3685032
- CAS No.
- Chemical Name:
- GSK3685032
- Synonyms
- GSK3685032
- CBNumber:
- CB89735154
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
GSK3685032 Chemical Properties,Uses,Production
Definition
GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition.
Mechanism of action
GSK3685032 is a potent first-in-class DNMT1-selective inhibitor shown via crystallographic studies to compete with the active-site loop of DNMT1 for penetration into hemimethylated DNA between two CpG base pairs. GSK3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition in vitro[1].
References
[1] M. Pappalardi. “Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.” Nature cancer 2 1 (2021): 1002–1017.
GSK3685032 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK3685032 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5225 | 58 |
Chengdu Junepharma Technology Co., Ltd | 19938173342 19181793067 | 1486288711@qq.com | China | 160 | 58 |
Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 3057 | 58 |
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | 024-024-88590548 18341751992 | 757984502@qq.com | China | 891 | 58 |
Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 13720134139 | orders@jknbiochem.com | China | 5777 | 58 |