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ChemicalBook >> CAS DataBase List >>9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester

9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester

9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester Structure
9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester structure
CAS No.
2256087-35-9
Chemical Name:
9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester
Synonyms
CL4H6 (removed);9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester;9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester
CBNumber:
CB89747267
Molecular Formula:
C59H113NO5
Molecular Weight:
916.53
MDL Number:
MOL File:
2256087-35-9.mol
Last updated:2024-07-02 08:55:39
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9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester Properties

Boiling point 854.2±65.0 °C(Predicted)
Density 0.915±0.06 g/cm3(Predicted)
solubility DMSO: soluble
form Viscous Liquid
pka 15.21±0.29(Predicted)

9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester Chemical Properties,Uses,Production

Description

CL4H6 is an ionizable cationic amino lipid (apparent pKa = 6.35) that has been used in the generation of lipid nanoparticles (LNPs).1 LNPs containing CL4H6 and encapsulating Factor VII-targeting siRNA decrease hepatic levels of Factor VII in mice. Intravenous administration of LNPs containing CL4H6 and encapsulating siRNA targeting CD45 accumulate in tumor-associated macrophages and encapsulating siRNAs targeting STAT3 and HIF-1α decrease tumor volume in OS-RC-2 renal cancer mouse xenograft models.2

References

1. Sato, Y., Hashiba, K., Sasaki, K., et al. Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo J. Control. Release 295,140-152(2019).
2. Shobaki, N., Sato, Y., Suzuki, Y., et al. Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy J. Control. Release 325,235-248(2020).

9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester Preparation Products And Raw materials

Raw materials

Preparation Products

9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester Suppliers

Global( 13)Suppliers
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Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 10985 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9707 58
Shanghai Changyu Medical Technology Co. Ltd. +86-13301875428 sales@changyuhe.com China 298 58
Shochem(Shanghai)Co.,Ltd +86-021-51783479 +86-13816874662 info@shochem.com China 304 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9412 58
Tianjin Yankai Scientific Co. Ltd. 18500985499 yankaisale@qq.com China 419 58
InvivoChem 13549236410 sales@invivochem.cn China 6755 58
Shanghai Easy CDMO Co.,Ltd 021-61734564 August@easycdmo.com China 10010 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 18112977050 cb5@aikonchem.com China 10529 58
Shandong Mopai Biotechnology Co., Ltd 13070690626 13053322091 admin@mopaikeji.com China 11056 58
Supplier Advantage
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Changyu Medical Technology Co. Ltd. 58
Shochem(Shanghai)Co.,Ltd 58
DC Chemicals 58
Tianjin Yankai Scientific Co. Ltd. 58
InvivoChem 58
Shanghai Easy CDMO Co.,Ltd 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 58
Shandong Mopai Biotechnology Co., Ltd 58
9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester CL4H6 (removed) 9-Octadecenoic acid (9Z)-, 1,1'-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester 2256087-35-9 C59H113NO5