INDEX NAME NOT YET ASSIGNED
- CAS No.
- 2672512-44-4
- Chemical Name:
- INDEX NAME NOT YET ASSIGNED
- Synonyms
- CBNumber:
- CB89835315
- Molecular Formula:
- C50H65F3IN7O6S
- Molecular Weight:
- 1076.07
- MDL Number:
- MOL File:
- 2672512-44-4.mol
INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production
Biological Activity
MS432 is a first-in-class and highly selective PD0325901-based von Hippel-Lindau-recruiting PROTAC degrader for MEK1 and MEK2. MS432 displays good plasma exposure in mice, exhibiting DC50 values of 31 nM and 17 nM for MEK1, MEK2 in HT29 cells respectively[1]. MS432 (compound 23) is potent in reducing MEK1/2 protein levels in COLO 205 cells (DC50 (MEK1) = 18 ± 7 nM, DC50 (MEK2) = 11 ± 2 nM) and UACC257 cells (DC50 (MEK1) = 56 ± 25 nM, DC50 (MEK2) = 27 ± 19 nM). MS432 (compound 23) displays good plasma exposure, which is approximately 3 to 20-fold higher than the GI50 values of compound 23 in the tested cancer cell lines[1].
References
[1]. Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader. J Med Chem. 2019 Dec 12;62(23):10897-10911.
INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials
Raw materials
Preparation Products
INDEX NAME NOT YET ASSIGNED Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1382 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4578 | 58 |
Supplier | Advantage |
---|---|
Aladdin Scientific | 58 |
Jilin Province Woda Biotechnology Co., Ltd. | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 58 |